1H NMR Analysis for Metabolites in Serum and Urine from Rats Administrated Chronically with La(NO3)3

Effects of Lanthanum on Human Lymphocytes Viability and DNA Strand Break

“…However, the biological mechanisms of rare earth metals ions action remain unclear. It has been demonstrated the interactions and effects of Ln, most of it La, with healthy mammal cells (Feng et al 2002;Zhao et al 2004). Lanthanum was shown to be cytotoxic to pulmonary macrophage of rats (Palmer et al 1987), and it was also reported to be cytotoxic increasing micronucleus incubated for 3 h at 37°C with La(NO 3 ) 3 (gray) and in the presence of vitamin E at 25 lM (white).…”

“…These applications introduce the possibility of contamination of human body with La through food chains. Lanthanum has a higher accumulation rate and lower metabolic rate than other rare earths in the body, which would make lanthanum accumulate more easily than other rare earths and induce more effects on the human body (Feng et al 2002). These same authors suggest, through rat serum analyses, that La(NO 3 ) 3 impairs the liver and kidney and causes irregular enzyme metabolism for animals chronically intaking La.…”

Use of NMR metabolomic plasma profiling methodologies to identify illicit growth-promoting administrations

“…All the sample spectra were phased and manually baseline corrected using ACDlabs (version 11.0, Toronto, ON, Canada). The sample spectra were referenced to lactate (CH 3 , δ1.33 ppm) [24,25]. Data reduction was carried out by manually binning the spectra and measuring the integral for each bin/bucket between 0.70 and 6.0 ppm-a total of 41 buckets were recorded.…”

Magnetic Resonance Spectroscopy (MRS) in Kidney Transplantation: Interest and Perspectives

“…Citrate, 2-oxoglutarate and hippurate were the most discriminating metabolites between treated group and control group whereas formate and dimethylamine showed almost not change. Other studies on administration of nephrotoxic compounds realised with urine and plasma of Sprague-Dawley rats focused on lanthanum, a rare earth compound used as fertilizer with a higher accumulation rate and a lower metabolic rate (Feng et al, 2002) or thioacetamide (Waters et al, 2005). In the first study, the authors showed that a 6-months long ingestion of La 3+ -induced nephro-and hepato-toxicity which could be highlighting by using NMR.…”