1H-magnetic resonance spectroscopy in social anxiety disorder

Howells, Fleur M.; Hattingh, Coenraad; Syal, Supriya; Breet, Elsie; Stein, Dan J.; Löchner, Christine

doi:10.1016/j.pnpbp.2014.12.008

Cited by 20 publications

(19 citation statements)

References 32 publications

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“…Previous published metabolite values were calculated as metabolite to Cr concentration ratios and compared with our quantification results. Our quantification results were generally within the range of previously published values (1-3, 7-9, 20, 21). …”

Section: Resultssupporting

confidence: 90%

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Spectral fitting using basis set modified by measuredB₀field distribution

Liu

Shen

2015

NMR Biomed.

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This study sought to demonstrate and evaluate a novel spectral fitting method to improve quantification accuracy in the presence of large magnetic field distortion, especially with high fields. Magnetic resonance spectroscopy (MRS) experiments were performed using a point resolved spectroscopy (PRESS)-type sequence at 7 Tesla. A double-echo gradient echo (GRE) sequence was used to acquire B0 maps following MRS experiments. The basis set was modified based on the measured B0 distribution within the MRS voxel. Quantification results were obtained after fitting the measured MRS data using the modified basis set. The proposed method was validated using numerical Monte Carlo simulations, phantom measurements, and by comparing occipital lobe MRS measurements under homogeneous and inhomogeneous magnetic field conditions. In vivo results acquired from voxels placed at thalamus and prefrontal cortex regions close to the frontal sinus agreed well with published values. Instead of noise-amplifying complex division, the proposed method treats field variations as part of the signal model, thereby avoiding inherent statistical bias associated with regularization. Simulations and experiments showed that the proposed approach reliably quantified results in the presence of relatively large magnetic field distortion.

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Section: Resultssupporting

confidence: 90%

“… * Published values were obtained from references 3, 8, and 20 Abbreviations: NAA: N-acetylaspartic acid; Cho: choline; Glu: glutamate; Gln: glutamine …”

Section: Figurementioning

confidence: 99%

Spectral fitting using basis set modified by measuredB₀field distribution

Liu

Shen

2015

NMR Biomed.

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“…The social anxiety starts in 13-19 ages, but it can happen in the early childhood (Damercheli, Kakavand & Jalali, 2017) and has large adverse effects on quality of social interactions, educational achievement, and welfare (Haller, Kadosh, Scerif, & Lau, 2015). It is one of the most common anxiety disorders with 6.1% prevalence in advanced countries and 2.1% in advancing countries (Howells et al, 2015). More than 90% of individuals with social anxiety disorder (SAD) report considerable impairment in one or more occupational functions (Himle et al, 2014) and around 70-80 percent of them receive secondary diagnoses of congruence disorders such as specific phobia, agoraphobia, major depression, and drug abuse (Barlow, 2008(.Various studies conducted in Iran imply a high degree of prevalence of this disorder, especially among women (Talepasand & Nokani, 2010;Mohammadi et al, 2008).…”

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confidence: 99%

The Effectiveness of Unified Transdiagnostic Treatment on Brain-Behavioral Systems and Anxiety Sensitivity in Female Students with Social Anxiety Symptoms

Roushani

Nejad

Arshadi

et al. 2018

International Journal of Psychology (IPA)

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The present research was conducted to study effectiveness of the unified transdiagnostic treatment on brain-behavioral systems and anxiety sensitivity in female students with social anxiety symptoms. The statistical population of this study included all undergraduate female students of Ahvaz Jundishapur University of medical sciences. In a pre-posttest experimental design with control group, 32 female students with the diagnosis of social anxiety disorder were selected by random cluster sampling. Then, all of the subjects were randomly allocated into two groups: experimental and control groups (16 students each). Research tools used in this study were Social Phobia Inventory (SPIN), Behavioral Activation/Behavioral Inhibition Scales (BIS/BIS) and Anxiety Sensitivity Inventory (ASI

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“…Also, alteration of Cho concentrations in the brain may relate to psychological symptoms. Studies reported that Cho in the left thalamus was significantly correlated with social anxiety and its related symptoms [42]. Elevated levels of Cho were found in the ACC of patients with schizophrenia [43] and in the dorsolateral prefrontal cortex of patients with major depressive disorder [44].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Mental Disorders Using Proton Magnetic Resonance Spectroscopy in Dialysis and Predialysis Patients

Zhang

Chen

et al. 2017

Kidney Blood Press Res

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Background/Aims: Psychological complications are prevalent in patients with chronic kidney disease (CKD). This study aimed to investigate mental disorders in stage 4-5 CKD patients, to detect metabolite concentrations in the brain by proton magnetic resonance spectroscopy (¹H-MRS) and to compare the effects of different dialysis therapies on mental disorders in end-stage renal disease (ESRD). Methods: The sample population was made up of predialysis (13), hemodialysis (HD) (13), and peritoneal dialysis (PD) patients (12). We collected the baseline data of patients’ age, sex, hemoglobin (Hb) and parathyroid hormone（PTH） levels. The predialysis patients served as the control group. The psychological status of the three groups was assessed using three psychological scales. ¹H-MRS was used to evaluate the relative metabolite concentrations in the bilateral amygdala, hippocampus and unilateral anterior cingulated cortex (ACC). Results: The psychological status was better in HD patients than in predialysis and PD patients. ¹H-MRS alterations were predominantly found in the ACC. Choline-containing compounds relative to creatine (Cho/Cr), myo-inositol relative to creatine (MI/Cr) and glutamate and glutamine relative to creatine (Glx/Cr) in the ACC were higher in HD patients. ¹H-MRS results were correlated with the baseline data and the scores of psychological scales. Conclusions: CKD patients showed different types of mental disorders as well as metabolite disturbances in the brain. The metabolite concentrations correlated with the psychological status which was better in HD than in predialytic and PD patients.

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1H-magnetic resonance spectroscopy in social anxiety disorder

Cited by 20 publications

References 32 publications

Spectral fitting using basis set modified by measuredB₀field distribution

Spectral fitting using basis set modified by measuredB₀field distribution

The Effectiveness of Unified Transdiagnostic Treatment on Brain-Behavioral Systems and Anxiety Sensitivity in Female Students with Social Anxiety Symptoms

Evaluation of Mental Disorders Using Proton Magnetic Resonance Spectroscopy in Dialysis and Predialysis Patients

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1H-magnetic resonance spectroscopy in social anxiety disorder

Cited by 20 publications

References 32 publications

Spectral fitting using basis set modified by measuredB0field distribution

Spectral fitting using basis set modified by measuredB0field distribution

The Effectiveness of Unified Transdiagnostic Treatment on Brain-Behavioral Systems and Anxiety Sensitivity in Female Students with Social Anxiety Symptoms

Evaluation of Mental Disorders Using Proton Magnetic Resonance Spectroscopy in Dialysis and Predialysis Patients

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Spectral fitting using basis set modified by measuredB₀field distribution

Spectral fitting using basis set modified by measuredB₀field distribution