1H, 13C, 15N NMR analysis of sildenafil base and citrate (Viagra) in solution, solid state and pharmaceutical dosage forms

Wawer, Iwona; Pisklak, Dariusz Maciej; Chilmończyk, Zdzisław

doi:10.1016/j.jpba.2005.01.046

Cited by 81 publications

(50 citation statements)

References 10 publications

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“…Interest in aminopyrazole synthesis and chemistry has recently been revived. [4][5][6][7][8] The established activity of Zaleplon (1), 9 Viagra (2) 10 as well as Allopurinol (3) 11 is surely behind this interest ( Figure 1). …”

Section: Introductionmentioning

confidence: 99%

Recent developments in aminopyrazole chemistry

Anwar¹,

Elnagdi²

2009

Arkivoc

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Recently reported syntheses of 3(5)-aminopyrazoles, 4-aminopyrazoles, and 1-aminopyrazoles as well as of diaminopyrazoles and their general pattern of reactivity towards mono-and bidentate electrophiles have been surveyed. Emphasis has also been laid on techniques for ascertaining the site selectivity in reactions with electrophiles, including single crystal X-ray structure analysis, 1 H-15 N HMBC, and NOE intensity difference experiments as well as other modern 2D NMR techniques. Some thermally induced cycloadditions have also been treated.

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Section: Introductionmentioning

confidence: 99%

Recent developments in aminopyrazole chemistry

Anwar¹,

Elnagdi²

2009

Arkivoc

View full text Add to dashboard Cite

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“…NMR has been proposed as the possible tool in natural products fingerprint and its use reported on foods and medicinal drugs [17][18][19], including the analysis of adulteration or food supplements spiked with synthetic products, when a single simple HPTLC plate can be sufficient [17][18][19][20][21][22][23]. The main problem to face is that also using a spectrometer of high resolution, the possibility of peaks overlapping remains very high.…”

Section: Hptlc Vs Nmrmentioning

confidence: 99%