1958 – Efficacy of modified compliance therapy for schizophrenia patients

Abstract

BackgroundSchizophrenia requires a large share of medical resources due to its early onset and chronic and severe nature. Compliance therapy is a therapy specifically designed to improve concordance with treatment for those with major mental illnesses. The aim of present study was to determine whether compliance therapy improves drug adherence and consequently makes better global functioning and improves quality of life in schizophrenic patients.MethodsThis randomized controlled clinical trial study was done in Noor hospital in 2008-2009. Patients were randomly assigned to receive the intervention consisting of 8 sessions of compliance therapy, or the control treatment consisting of an equal number of sessions of supportive counseling. All patients were evaluated by Heinrichs Quality of Life scale, Global Assessment of Functioning (GAF) scale, and Positive and Negative Symptoms Scale (PANSS) at baseline, third month and sixth month follow-up after intervention.Results76 schizophrenic patients who met criteria of study were enrolled in the trial. Our data showed a significant main effect for interaction of group and time for GAF scale, Heinrichs Quality of Life scale and PANSS.ConclusionsThe findings of our study showed that compliance therapy can improve not only global functioning but also quality of life in schizophrenic patients. In addition, PNASS was improved during the six months follow up in compliance therapy group.

The effect of adherence therapy on medication adherence, health beliefs, self‐efficacy, and depressive symptoms among patients diagnosed with major depressive disorder

“…Such findings supported the positive effect of medication adherence on suppressing depressive symptoms among patients with MDD, which is the core aim of prescribing the antidepressant. The finding supported by RCT studies, patients who received AT reported significant improvements in symptom severity over time (over 6 months and 18 months follow-up) compared with TAU in patients with SSD (Chien et al 2015(Chien et al , 2016Omranifard et al 2013). On the other hand, it is not consistent with studies that found that AT did not significantly improve psychiatric symptomatology than the control group (Anderson et al 2010;Gray et al 2006).…”

Motivational Interviewing–Based Compliance/Adherence Therapy Interventions to Improve Psychiatric Symptoms of People With Severe Mental Illness: Meta-Analysis

“…The summary ES (Hedges’s g ) across all primary study MI-based CAT intervention and control comparisons was .45 (95% CI [0.139, 0.750]; Z = 2.851, p = .004) in the .20 to .50 range to be considered moderate (Borenstein et al, 2009). Although the summary ES of this meta-analytic study is considered moderate, only six primary studies (Figure 2) had significant ESs (Anderson et al, 2010; Chien et al, 2015; Gray et al, 2004; Maneesakorn et al, 2007; Omranifard et al, 2012; Schulz et al, 2013). Most studies tended toward positive effects though they were not statistically significant.…”

“…As a result of the winnowing process (Figure 1), 16 studies were deemed eligible as primary studies for this meta-analytic study. They are identified by asterisks in the reference list (Anderson et al, 2010; Barkhof et al, 2013; Cavezza, Aurora, & Ogloff, 2013; Chien et al, 2015; Gray et al, 2006; Gray, Wykes, Edmonds, Leese, & Gournay, 2004; Hayward et al, 1995; Interian et al, 2013; Kemp et al, 1998; Maneesakorn et al, 2007; O’Donnell et al, 2003; Omranifard, Karahmadi, Jannesari, & Maracy, 2012; Schulz et al, 2013; Staring et al, 2010; Tsang & Wong, 2005; von Bormann, Robson, & Gray, 2015).…”

Adherence to drug treatment among schizophrenic patients in Jigawa State, Nigeria

“…10 Poor adherence to antipsychotic medication in schizophrenia have been associated with rehospitalisation and relapse in cross sectional studies and studies monitoring hospital admissions among patients being in shortage of supplies of antipsychotic medications. 12 Data from study revealed that 74 % of the patients discontinued their medication before 18 months, i.e. either to nonadherence or to another antipsychotic medication.…”

“…6,16 Patients with mental illness who are non-adherent also are at risk for homelessness, incarceration, and violence. 7,12 Poor adherence can be responsible for avoidable hospital admissions and increased visits to the emergency department. 2 Thus, since adherence is determined to a large extent by one's income, it means non-adherence in a significant proportion of the subjects might be accounted for by these economic considerations.…”