19. Nutrition for patients with thalassemia

Fung, Ellen B.; Schroepfer, C.; Lal, Ashutosh

doi:10.3920/978-90-8686-822-3_19

Handbook of Nutrition and Diet in Leukemia and Blood Disease Therapy 2016

DOI: 10.3920/978-90-8686-822-3_19

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19. Nutrition for patients with thalassemia

Ellen B. Fung

C. Schroepfer

Ashutosh Lal

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2021

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“…Very few prospective, longitudinal, large-scale interventional studies have been completed that provide a robust analysis of the relationship between nutrition and morbidity in Thal. Moreover, the etiology of nutritional inadequacy in Thal is multifactorial, associated with poor nutrient intake (poor appetite, cultural preferences, decreased nutrient density, gastrointestinal distress), increased nutrient requirements (due to red blood cell turnover, oxidative stress), and increased nutrient loss or sequestration 6–8. Despite these challenges, a thorough synopsis of currently available information is a crucial first step towards generating nutritional recommendations for patients with Thal.…”

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confidence: 99%

Nutrition in Thalassemia: A Systematic Review of Deficiency, Relations to Morbidity, and Supplementation Recommendations

Goldberg¹,

Lal

Fung

2021

Journal of Pediatric Hematology/Oncology

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Background: Reports of nutritional deficiencies in patients with thalassemia (Thal) are common. Despite its importance, however, nutritionally focused research in Thal has been limited by inadequate sample size, inconsistent methodology, a lack of control comparisons, and few interventional trials. Due to these limitations, clinicians lack evidence-based nutrition recommendations to support clinical decision-making. This systematic review summarizes observed relationships between nutrition and morbidity in Thal published in the last 3 decades.Methods: PubMed, Web of Science, and Embase were screened for articles pertaining to nutrition in Thal using comprehensive search terms. Studies performed in humans, written in English, and published between 1990 and 2020 were included. Over 2100 manuscripts were identified, from which 97 were included.Results: Patients with Thal were most often deficient in vitamins A, C, D, selenium, and zinc. Prevalence of nutritional deficiency was positively correlated with age and iron overload. Evidence to support the role of vitamin D and zinc for bone health was observed; zinc was also found to improve glucose metabolism.Conclusions: Due to the risk for multinutrient deficiency, nutritional status should be assessed annually in patients with Thal with prompt nutrient replacement when deficiency is detected. Routine supplementation with vitamin D and zinc is recommended.

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confidence: 99%

Nutrition in Thalassemia: A Systematic Review of Deficiency, Relations to Morbidity, and Supplementation Recommendations

Goldberg¹,

Lal

Fung

2021

Journal of Pediatric Hematology/Oncology

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show abstract

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19. Nutrition for patients with thalassemia

Cited by 1 publication

References 65 publications

Nutrition in Thalassemia: A Systematic Review of Deficiency, Relations to Morbidity, and Supplementation Recommendations

Nutrition in Thalassemia: A Systematic Review of Deficiency, Relations to Morbidity, and Supplementation Recommendations

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