Nutrition in Thalassemia: A Systematic Review of Deficiency, Relations to Morbidity, and Supplementation Recommendations

Abstract

Background: Reports of nutritional deficiencies in patients with thalassemia (Thal) are common. Despite its importance, however, nutritionally focused research in Thal has been limited by inadequate sample size, inconsistent methodology, a lack of control comparisons, and few interventional trials. Due to these limitations, clinicians lack evidence-based nutrition recommendations to support clinical decision-making. This systematic review summarizes observed relationships between nutrition and morbidity in Thal published in the last 3 decades.Methods: PubMed, Web of Science, and Embase were screened for articles pertaining to nutrition in Thal using comprehensive search terms. Studies performed in humans, written in English, and published between 1990 and 2020 were included. Over 2100 manuscripts were identified, from which 97 were included.Results: Patients with Thal were most often deficient in vitamins A, C, D, selenium, and zinc. Prevalence of nutritional deficiency was positively correlated with age and iron overload. Evidence to support the role of vitamin D and zinc for bone health was observed; zinc was also found to improve glucose metabolism.Conclusions: Due to the risk for multinutrient deficiency, nutritional status should be assessed annually in patients with Thal with prompt nutrient replacement when deficiency is detected. Routine supplementation with vitamin D and zinc is recommended.

Talasemia : sebuah Tinjauan Pustaka

“…Komplikasi yang dapat terjadi pada talasemia mayor antara lain sebagai berikut (Ali et al, 2021;Bajwa & Basit, 2022;Goldberg et al, 2022;Nafisa et al, 2020). a.…”

“…Selain itu direkomendasikan juga suplementasi Vitamin D dan Seng untuk hampir semua pasien talasemia. Pemantauan terhadap status nutrisi pasien talasemia dapat dilakukan sehingga koreksi defisiensi nutrisi dapat dilakukan segera apabila dicurigai (Goldberg et al, 2022) (Bajwa & Basit, 2022) (Goldberg et al, 2018). c. Hindari infeksi, pasien harus berusaha semaksimal mungkin untuk menghindari infeksi terutama setelah splenektomi.…”