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Belguendouz, Houda; Messaoudene, D.; Lahmar-Belguendouz, K.; Ahmedi, M.L.; Hartani, D.; Otmani, F.; Lahlou-Boukoffa, O.S.; Djeraba, Zineb; Youinou, Pierre; Touil-Boukoffa, Chafia

doi:10.1016/j.cyto.2013.06.022

Cited by 3 publications

(2 citation statements)

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“…The results showed that the extract could modulate immunity by inducing macrophages to intracellular expression of IFN-c. IFN-c also stimulates macrophages and is involved in the development of Th1 cells. The cellular effects of IFN-c include up-regulation of pathogen recognition, antigen processing and presentation, inhibition of viruses, inhibition of cellular proliferation, and modifying apoptosis and immunomodulation (Belguendouz et al, 2011;Lyu & Park, 2005). These findings are important and H. triquetrifolium can be considered as a very suitable candidate for modulating macrophage function.…”

Section: Discussionmentioning

confidence: 99%

Modulation of cytokine production from cultured mononuclear cells of leukemia patients by Hypericum triquetrifolium Turra methanolic extract

Ad’hiah

Ibraheem

Abbood

2018

Arab Journal of Basic and Applied Sciences

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The effect of Hypericum triquetrifolium Turra (Family: Hypericaceae) methanolic extract on an in vitro cytokine release (IL-2, IL-4, IL-10, IL-17A and IFN-c) from cultured mononuclear cells was determined. The cells were obtained from acute lymphoblastic (ALL) and acute myelogenous leukemic (AML) Iraqi patients. Two concentrations (1.146 and 1.719 mg/ml) of the extract were tested. They were correspondent to 20 and 30%, respectively of the plant IC 50 (5.73 mg/ml). Chemical analysis of the extract showed its richness in flavonoids (115.73 mg/ ml). Assessments of cytokine levels in supernatants of cultured cells revealed that ALL, AML or control cells responded differently to the plant extract in their production of IL-2, IL-10, IL-17A and IFN-c, but leukemic cells were better than control cells in their response, while there was no effect on IL-4 production. The results suggested that H. triquetrifolium methanolic extract exerted immunomodulatory effects on cultured cells.

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Section: Discussionmentioning

confidence: 99%

Modulation of cytokine production from cultured mononuclear cells of leukemia patients by Hypericum triquetrifolium Turra methanolic extract

Ad’hiah

Ibraheem

Abbood

2018

Arab Journal of Basic and Applied Sciences

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“…7,8 Our data indicate that both CD4 and CD8 T cells subset could play a key role in the pathogenesis of BD, probably by their ability to produce IFNγ. This hypothesis is supported by strong relationship observed between T cell activation IFN γ levels in vivo and in vitro system (Table 1).…”

Section: Ocularmentioning

confidence: 99%

T Cells Activation and Interferon-γ/Nitric Oxide Production during Behçet Disease: A Study in Algerian Patients

Djaballah-Ider¹,

Chaib²,

Belguendouz³

et al. 2012

Ocular Immunology and Inflammation

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Analysis of the association between Fc receptor family gene polymorphisms and ocular Behçet’s disease in Han Chinese

Zhang

Qin

et al. 2018

Sci Rep

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Fc receptors are known to have a pivotal role in the initiation and regulation of many immunological and inflammatory processes. This study aimed to investigate the association of Fc receptor family gene polymorphisms with ocular Behçet’s disease (BD) in Han Chinese. A two stage case–control study was performed in 1022 BD cases and 1803 healthy controls. Twenty-three SNPs were genotyped using the MassARRAY system (Sequenom), TaqMan SNP Genotyping Assay and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The expression of FCGR3A was examined by real-time PCR and cytokine production was measured by enzyme linked immunosorbent assay (ELISA). A significantly higher frequency of the FCGR3A/rs428888 CT genotype (Pc = 1.96 × 10−7, OR = 1.897) and a lower frequencies of CC genotype and C allele (Pc = 1.96 × 10−7, OR = 0.527; Pc = 7.22 × 10−7, OR = 0.554 respectively) were found in ocular BD as compared with controls. Functional experiments showed an increased FCGR3A expression (P = 0.005) and increased cytokine protein expressions of MCP-1, IL-1β and TNF-α by LPS stimulated PBMCs in CT carriers of FCGR3A rs428888 compared to CC carriers (P = 0.034; P = 0.025; P = 0.04; respectively). Our findings demonstrate that FCGR3A/rs428888 confers genetic susceptibility for ocular BD in Han Chinese.

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19

Cited by 3 publications

References 0 publications

Modulation of cytokine production from cultured mononuclear cells of leukemia patients by Hypericum triquetrifolium Turra methanolic extract

Modulation of cytokine production from cultured mononuclear cells of leukemia patients by Hypericum triquetrifolium Turra methanolic extract

T Cells Activation and Interferon-γ/Nitric Oxide Production during Behçet Disease: A Study in Algerian Patients

Analysis of the association between Fc receptor family gene polymorphisms and ocular Behçet’s disease in Han Chinese

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