[18F]Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (PET/CT) Physiologic Imaging of Choroidal Melanoma: Before and After Ophthalmic Plaque Radiation Therapy

Regression of Uveal Melanoma After Ru-106 Brachytherapy and Thermotherapy Based on Metabolic Activity Measured by Positron Emission Tomography/Computed Tomography

“…Positive SUV rate in previous studies ranged from 17% to 60%. 14,19,21,25 Among metabolically active tumors, initial tumor height was not correlated with tumor regression after treatment at all time intervals. Initial tumor height, however, was correlated with tumor regression among metabolically inactive tumors.…”

Initial PET/CT Staging for Choroidal Melanoma: AJCC Correlation and Second Nonocular Primaries in 333 Patients

“…Ophthalmic oncology saw its first clinical use in 2004 when Finger et al and Freudenberg et al reported on detection of metastatic choroidal melanoma (5,6). Further studies have focused on the primary tumor establishing correlations with size, genetic status, histopathology, prognostic value, and response to radiation therapy (7)(8)(9)(10)(11). Since the Collaborative Ocular Melanoma Study (COMS) group suggested that physical examination, liver function tests, and a chest x-ray were inadequate procedures for metastases screening, there has been renewed interest in alternative diagnostic methods (12).…”

Assessment of Response to Therapy

“…PET has also been applied for choroidal melanoma with promising results (Finger and Chin 2011). Following a cohort of 217 patients diagnosed with uveal melanoma and eligible for ophthalmic plaque brachytherapy, it was shown that treatment-related diminished SUV may correlate to both local control and loss of ability of choroidal melanoma to metastasize over time (Finger and Chin 2011).…”

“…Following a cohort of 217 patients diagnosed with uveal melanoma and eligible for ophthalmic plaque brachytherapy, it was shown that treatment-related diminished SUV may correlate to both local control and loss of ability of choroidal melanoma to metastasize over time (Finger and Chin 2011). It was concluded that PET/CT imaging can be used to assess choroidal melanomas for their response to treatment.…”