2014
Abstract: Positive metabolic activity of uveal melanoma based on the positron emission tomography/computed tomography was significantly associated with rapid initial tumor regression after combined plaque radiotherapy and thermotherapy, suggesting a prognostic value for this diagnostic approach.
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Cited by 5 publications
(4 citation statements)
References 28 publications
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“…6,24 A different mix of tumor shapes and regression patterns among cases and controls is likely when a nonrandomized, retrospective, comparative analysis is based on specific types of radiotherapy or predictor, and likely will introduce bias to such comparisons. 11 Typically, studies on regression of uveal melanomas have failed to report tumor shape 3,[5][6][7][8][9][10][11][12][14][15][16][17][18]20,[22][23][24]27 or have mentioned only the proportion of dome-shaped 29 (84% vs. 35% in our unselected series) or mushroom-shaped melanomas (16%, 22%, and 39% vs. 17% in our series). 21,26,29 Consequently, it is not possible to assess the extent of such bias.…”
Section: Discussionmentioning
confidence: 90%
“…6,24 A different mix of tumor shapes and regression patterns among cases and controls is likely when a nonrandomized, retrospective, comparative analysis is based on specific types of radiotherapy or predictor, and likely will introduce bias to such comparisons. 11 Typically, studies on regression of uveal melanomas have failed to report tumor shape 3,[5][6][7][8][9][10][11][12][14][15][16][17][18]20,[22][23][24]27 or have mentioned only the proportion of dome-shaped 29 (84% vs. 35% in our unselected series) or mushroom-shaped melanomas (16%, 22%, and 39% vs. 17% in our series). 21,26,29 Consequently, it is not possible to assess the extent of such bias.…”
Section: Discussionmentioning
confidence: 90%
“…Our findings also cast doubt on the validity of restricting analysis of regression of uveal melanomas to a specific time point or interval, a method typically used. 6,8,10,11,23,24 For example, Kaiserman et al 20 defined the ITRR as the average monthly regression in thickness during the first 3 months. The median was 3.9% per month for 147 eyes treated with ruthenium plaques as compared to 4.4% for our 330 eyes, a comparable result.…”
Section: Discussionmentioning
confidence: 99%
“…In the literature review, descriptions of regression of choroidal melanoma after treatment have largely been limited to ultrasonographic tumor thickness reduction. 13 – 24 Rashid et al 39 reported 43% decrease in thickness and 42% decrease in cross-sectional area of tumor after 106 Ru and 125 I plaque brachytherapy. A recent study by Rashid et al 40 also reported that initial tumor thickness was the predominant clinical predictor of regression rate of choroidal melanomas after 106 Ru and 125 I brachytherapy.…”
Section: Discussionmentioning
confidence: 99%
“…Prior descriptions of uveal melanoma regression have largely concentrated on tumor-size (typically height) following brachytherapy with cobalt ( 60 Co), iodine ( 125 I) and ruthenium ( 106 Ru) plaques, charged particles, and gamma knife. 13 – 24 However, in 1982, Wilkes and Gragoudas 25 examined choroidal melanoma regression after proton beam irradiation, where they considered tumor thickness, pigmentation, vascularity, and subretinal fluid (SRF). Most recently, our group described regression patterns of iris melanoma following 103 Pd plaque.…”
Section: Introductionmentioning
confidence: 99%
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