18F-fluorodeoxyglucose positron emission tomography and computed tomography in anaplastic thyroid cancer

Poisson, Thomas; Deandreis, Désirèe; Leboulleux, Sophie; Bidault, François; Bonniaud, G.; Baillot, Sylvain; Aupérin, Anne; Ghuzlan, Abir Al; Travagli, Jean-Paul; Lumbroso, J.; Baudin, Éric; Schlumberger, Martin

doi:10.1007/s00259-010-1570-6

Cited by 86 publications

(48 citation statements)

References 37 publications

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“…Death is more often related to distant metastases than to local disease progression. Poisson et al (54) observed that FDG-PET/CT was the reference imaging modality for ATC at initial staging because it was more effective than CT was in detecting cervical and mediastinal lymph nodes. FDG-PET/CT was more sensitive than bone scintigraphy; the volume of FDG uptake (O300 ml) and the intensity of FDG uptake (SUVmax R18) were significant prognostic factors for survival; FDG-PET/CT was also more efficient in the early assessment of tumor volume and in the response to treatment than CT was.…”

Section: European Journal Of Endocrinologymentioning

confidence: 99%

IMAGING IN ENDOCRINOLOGY: 2-[18F]-fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography in differentiated thyroid carcinoma: clinical indications and controversies in diagnosis and follow-up

Salvatori

Biondi

Rufini

2015

European Journal of Endocrinology

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In recent years, 2-[ 18 F]-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (FDG-PET/CT) has emerged as an important tool for the postoperative management of patients with differentiated thyroid cancer (DTC) and it is widely used in selected clinical situations. The most valuable role that FDG-PET/CT plays in clinical practice is that it can be used to obtain prognostic information in patients with increasing thyroglobulin (Tg) levels and negative 131 I whole-body scan post-thyroidectomy and radioiodine (RAI) ablation. FDG-PET/CT may also have a potential role in the initial staging and follow-up of high-risk patients with aggressive histological subtypes, in the identification of patients who are at the highest risk of disease-specific mortality, in the management of patients with RAI-refractory disease, in clinical trials of novel targeted therapies in patients with advanced metastatic disease, and in the evaluation of thyroid nodules with indeterminate fineneedle aspiration for cytology. However, several controversies remain to be resolved, namely: the cutoff value of Tg in the selection of DTC patients for FDG-PET/CT, whether FDG-PET/CT scanning should be performed under thyrotropin stimulation or suppression, and the clinical significance of thyroid FDG-PET/CT incidentalomas. The aim of the present article is to provide an overview of the data about the molecular basis for, clinical indications of, and controversies related to the use of FDG-PET/CT in patients with DTC.

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Section: European Journal Of Endocrinologymentioning

confidence: 99%

IMAGING IN ENDOCRINOLOGY: 2-[18F]-fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography in differentiated thyroid carcinoma: clinical indications and controversies in diagnosis and follow-up

Salvatori

Biondi

Rufini

2015

European Journal of Endocrinology

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“…As a result of aggressive tumor behavior and ineffective therapeutic efficacy, patients do poorly (Besic & Gazic 2013). Positron emission tomography (PET)/computed tomography (CT) is the primary imaging modality for ATC at initial staging and has utility in the early evaluation of treatment response and follow-up (Poisson et al 2010). Distant metastases, extensive local infiltration, and regional lymph node metastases have been found at autopsy in 91, 76, and 51% of cases respectively.…”

Section: Dear Editormentioning

confidence: 99%

Identification of insertions in PTEN and TP53 in anaplastic thyroid carcinoma with angiogenic brain metastasis

Sadow¹,

Dias‐Santagata²,

Zheng³

et al. 2015

Endocrine-Related Cancer

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“…Furthermore FDG PET/CT seems promising in the early evaluation of treatment response and follow-up [28].…”

Section: Role Of Imagingmentioning

confidence: 99%

“…PET may therefore improve disease detection and impact significantly on the management of patients with ATC relative to other imaging modalities [27,28].…”

Section: Role Of Imagingmentioning

confidence: 99%

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Detection of Extensive Metastases from Anaplastic Thyroid Cancer by F-18 FDG-PET/CT

Vorster

Sathekge²

2011

TONMEDJ

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Background: Survival with anaplastic thyroid cancer is dependent on how rapid multimodality treatment (chemotherapy, radiotherapy and surgery) and thus accurate assessment of the extent of the disease critical to predict prognosis and therapy planning. Methods & Results:We present a case of anaplastic cancer in a 54-year-old woman who presented with a supra-sternal lump which has decreased in size in response to chemo-and radiotherapy. CT and FDG-PET/CT scan were performed after therapy. CT demonstrated supra-sternal and lung metastases. FDG-PET/CT demonstrated the primary lesion and its distant widespread metastases, beyond the lung and supra-sternal mass.Conclusion: This case emphasizes the need for FDG PET/CT if there is equivocal clinical, laboratory, and radiological evidence of recurrence and metastases, especially if the suspected finding seems can be very unusual for metastatic lesions.

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18F-fluorodeoxyglucose positron emission tomography and computed tomography in anaplastic thyroid cancer

Abstract: FDG PET/CT appears to be the reference imaging modality for ATC at initial staging and seems promising in the early evaluation of treatment response and follow-up.

Cited by 86 publications

References 37 publications

IMAGING IN ENDOCRINOLOGY: 2-[18F]-fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography in differentiated thyroid carcinoma: clinical indications and controversies in diagnosis and follow-up

IMAGING IN ENDOCRINOLOGY: 2-[18F]-fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography in differentiated thyroid carcinoma: clinical indications and controversies in diagnosis and follow-up

Identification of insertions in PTEN and TP53 in anaplastic thyroid carcinoma with angiogenic brain metastasis

Detection of Extensive Metastases from Anaplastic Thyroid Cancer by F-18 FDG-PET/CT

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