18F-Fluorodeoxiglucose Positron Emission Tomography for the Evaluation of Neoadjuvant Therapy Response in Esophageal Cancer

Aguirre, A.C. Rebollo; Ramos-Font, C.; Villegas, R.; Cook, Gary; Elvira, J.M. Llamas; Romero-Tabares, A.

doi:10.1097/sla.0b013e3181b0c3a6

Cited by 57 publications

(11 citation statements)

References 29 publications

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“…Normal‐sized lymph nodes are not detected by CT, but PET scans can detect metastases in normal‐sized lymph nodes through functional imaging. However, there are some limitations of PET imaging 11,39 . Small, early stage tumors may go undetected due to poor spatial resolution.…”

Section: Discussionmentioning

confidence: 99%

Comparative study between endoscopic ultrasonography and positron emission tomography-computed tomography in staging patients with esophageal squamous cell carcinoma

Yen

Chung

et al. 2011

Diseases of the Esophagus

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Treatment strategy of esophageal cancer mainly depends on accurate staging. At present, no single ideal staging modality is superior to another in preoperative tumor-node-metastasis (TNM) staging of patients with esophageal cancer. We aimed to investigate the efficacy of endoscopic ultrasonography (EUS) and positron emission tomography-computed tomography (PET-CT) for staging of esophageal cancer. We retrospectively studied 118 consecutive patients with esophageal squamous cell carcinoma who underwent esophagectomy with or without neoadjuvant chemoradiotherapy (CRT) over a near 3-year period between January 2005 and November 2008 at a tertiary hospital in Taiwan. Patients were separated into two groups: without neoadjuvant CRT (group 1, n= 28) and with CRT (group 2, n= 90). Medical records of demographic data and reports of EUS and PET-CT of patients before surgery were reviewed. A database of clinical staging by EUS and PET-CT was compared with one of pathological staging. The accuracies of T staging by EUS in groups 1 and 2 were 85.2% and 34.9%. The accuracies of N staging by EUS in groups 1 and 2 were 55.6% and 39.8%. The accuracies of T and N staging by means of PET-CT scan were 100% and 54.5% in group 1, and were 69.4% and 86.1% in group 2, respectively. In group 2, 38 of 90 patients (42.2%) achieved pathologic complete remission. Among them, two of 34 (5.9%) and 12 of 17 (70.6%) patients were identified as tumor-free by post-CRT EUS and PET-CT, respectively. EUS is useful for initial staging of esophageal cancer. PET-CT is a more reliable modality for monitoring treatment response and restaging. Furthermore, the accuracy of PET-CT with regard to N staging is higher in patients who have undergone CRT than those who have not.

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Section: Discussionmentioning

confidence: 99%

Comparative study between endoscopic ultrasonography and positron emission tomography-computed tomography in staging patients with esophageal squamous cell carcinoma

Yen

Chung

et al. 2011

Diseases of the Esophagus

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“…Other considerations that may contribute to differences among studies are organ site, type of tumor, size of the lesion, and metabolic state of the tumor cells. For example, the reported sensitivity and specificity PET CT of lung lesions is 96% (range: 83–100%) and 79% (range: 52–100%) [11, 12], for colorectal cancer 97% (95–99%) and 75.6% (64–88%) [13, 14], for Hodgkin lymphomas 84% (71–92%) and 90% (84–94%) [15], non-Hodgkin lymphomas 72% (61–82%) and 100% (97–100%) [15], esophageal tumors 51% (27–93%) and 84% (41.7–95.2%) [16, 17], and head and neck tumors 98% (88–100%) and 92% (75–100%), respectively [18–20]. One of the limitations of our study was the enrollment of patients with known history of cancer.…”

Section: Discussionmentioning

confidence: 99%

Correlation of Tissue Biopsy and Fine Needle Aspiration Cytology with Positron Emission Tomography Results

Rosen

Herrington

Bhargava

et al. 2011

Pathology Research International

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F-18-fluorodeoxyglucose (FDG) Positron Emission Tomography (PET) scans are positive in any condition which increases metabolism in a mass or tissue and are therefore not specific for neoplastic conditions. The use of an SUV cutoff value of 2.5 may not always help discriminate between benign and malignant cases. For a practicing cytopathologist doing adequacy checks during an image-guided procedure, it may be of value to be aware that elevated SUV values are not always indicative of a malignant process, and vice versa.

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“…18 F‐FDG PET has been shown to have similar accuracy to EUS in treatment response assessment and to be feasible in the majority of patients compared with EUS, which was not feasible or was suboptimal in up to 20% of patients . The sensitivity and specificity of 18 F‐FDG PET were found to range between 70% and 100%, and 55% and 100%, respectively . Evidence suggests that early 18 F‐FDG PET performs as well as posttreatment assessment in this setting .…”

Section: F‐fdg Petmentioning

confidence: 99%

Performance of different imaging modalities in assessment of response to neoadjuvant therapy in primary esophageal cancer

et al. 2015

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18F-Fluorodeoxiglucose Positron Emission Tomography for the Evaluation of Neoadjuvant Therapy Response in Esophageal Cancer

Cited by 57 publications

References 29 publications

Comparative study between endoscopic ultrasonography and positron emission tomography-computed tomography in staging patients with esophageal squamous cell carcinoma

Comparative study between endoscopic ultrasonography and positron emission tomography-computed tomography in staging patients with esophageal squamous cell carcinoma

Correlation of Tissue Biopsy and Fine Needle Aspiration Cytology with Positron Emission Tomography Results

Performance of different imaging modalities in assessment of response to neoadjuvant therapy in primary esophageal cancer

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