18F-FDG PET reveals an adrenocortical carcinoma in a bilateral adrenal multinodular disease

Libé, Rossella; Jazeron, Jean-François; Louiset, Estelle; Groussin, Lionel

doi:10.1007/s12020-018-1757-3

Cited by 5 publications

(4 citation statements)

References 3 publications

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“…There were small number of unilateral ACC reports with 18 F-FDG PET/CT studies. [3,6,7] To the best of our knowledge, 18 F-FDG PET/CT findings of bilateral ACC reported here are probably the first reported in the literature.…”

Section: Discussionmentioning

confidence: 59%

18F-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography for preoperative planning in a rare case of hyperfunctional bilateral adrenocortical carcinoma and review of literatures

2020

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Adrenal cortical carcinoma (ACC) is a rare aggressive endocrine tumor with poor prognosis. About 60% of ACC are functional tumors. Bilateral ACC is extremely rare, roughly 2%–10% of cases. Diagnosis and staging of ACC by imaging modalities are crucial for preoperative planning and prognostication. Detection of hyperfunctional bilateral adrenocortical carcinoma by 18F-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography ( 18 F- FDG PET/CT) has never been reported. Herein, we report a male patient who presented with Cushing's syndrome, type II diabetes mellitus due to Cushing's syndrome, and hypogonadism with biopsy confirmed left ACC. He underwent 18 F-FDG PET/CT to evaluate the contralateral adrenal mass and to plan for laparoscopic adrenalectomy, which subsequently confirmed bilateral ACC. Furthermore, 18 F-FDG PET/CT was useful in staging, which revealed paraaortic lymph node and lung metastasis.

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Section: Discussionmentioning

confidence: 59%

18F-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography for preoperative planning in a rare case of hyperfunctional bilateral adrenocortical carcinoma and review of literatures

2020

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“…PET/CT showed that the uptake of FDG in the tumor area was intense but showed inhomogeneous enhancement, while there was no uptake in the adrenal hyperplasia area. This may be related to the overexpression of Glucose transporter1 (GLUT1) and hexokinase II in the tumor area ( 4 ).…”

Section: Discussionmentioning

confidence: 99%

Case Report: Surgery to remove adrenocortical oncocytic carcinoma from an Asian male

et al. 2023

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Adrenocortical oncocytic carcinoma is a rare type of adrenocortical tumor. Its clinical characteristics and biological behavior need to be further evaluated after the accumulation of cases. Here we report a case of adrenocortical oncocytic carcinoma in an Asian male with scoliosis. We performed an operation on this patient. Because the patient's scoliosis was limited during the operation and the tumor protruded into the chest, we decided to adopt open surgery in the supine position. During the operation, we found a tumor about 8 cm in diameter in the right adrenal region and successfully removed it. The patient recovered well after surgery, and there was no tumor recurrence after one year of follow-up. Pathological results confirmed the diagnosis of adrenocortical oncocytic carcinoma. Pathological features showed tumor cell invasion of adipose tissue, with atypical mitosis and abundant esinophilic cytoplasm. Immunohistochemistry showed that nucleus related antigen (Ki67) index was more than 15% and the positive pathological staining of Synaptophysin (Syn), Melanoma A (Melan A), Inhibin and calretinin. The incidence rate of adrenocortical oncocytic carcinoma is extremely rare. Abdominal Computed tomography (CT) scans and other imaging examination methods are not specific. For larger adrenal tumors, the diagnosis of this disease should be considered. For patients with adrenocortical oncocytic carcinoma who have not yet metastasized, we may achieve sound treatment effects and reduce recurrence by removing the tumor, retroperitoneal fat around the tumor and locoregional lymph nodes.

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“…PET/CT showed that the uptake of FDG in the tumor area was intense but showed inhomogeneous enhancement, while there was no uptake in the adrenal hyperplasia area. This may be related to the overexpression of GLUT1 and hexokinase II in the tumor area [4]. The Weiss scoring system is the most important method to differentiate benign and malignant adrenocortical tumors [5].…”

Section: Discussionmentioning

confidence: 99%

Surgery to Remove Adrenocortical Oncocytic Carcinoma from an Asian Male with Scoliosis

Liu¹,

Huang²,

Wang³

et al. 2021

Preprint

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Background: Adrenocortical oncocytoma is a rare type of adrenocortical carcinoma. Its clinical characteristics and biological behaviour need to be further evaluated after the accumulation of cases.Case presentation: We report a case of adrenocortical oncocytic carcinoma in an Asian male with scoliosis. We performed an operation on this patient. Because the patient's scoliosis was limited during the operation and the tumor protruded into the chest, we decided to adopt open surgery in the supine position. During the operation, we found a tumor about 8 cm in diameter in the right adrenal region. There was local adhesion with the surrounding tissues. The surface blood vessels of the tumor were distended. After careful dissection and ligation of the blood vessels around the tumor, the adrenal tumor was completely dissociated and removed. The patient recovered well, and his hypertension was controlled after surgery. Pathological results confirmed the diagnosis of adrenocortical oncocytic carcinoma. Pathological features showed that the tumor cells were arranged in nests, with pathological mitosis, abundant cytoplasm, eosinophilia, and invasion of adipose tissue. Immunohistochemistry showed that Ki67 index was more than 15%. Conclusions: The incidence rate of eosinophilic adrenocortical carcinoma is very low. CT scans and other imaging examination methods are not specific. For larger adrenal tumors, the diagnosis of this disease should be considered. For patients with adrenal cortical carcinoma who have not yet metastasized, we can achieve sound treatment effects and reduce recurrence by removing the tumor, retroperitoneal fat around the tumor and locoregional lymph nodes.

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18F-FDG PET reveals an adrenocortical carcinoma in a bilateral adrenal multinodular disease

Cited by 5 publications

References 3 publications

18F-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography for preoperative planning in a rare case of hyperfunctional bilateral adrenocortical carcinoma and review of literatures

18F-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography for preoperative planning in a rare case of hyperfunctional bilateral adrenocortical carcinoma and review of literatures

Case Report: Surgery to remove adrenocortical oncocytic carcinoma from an Asian male

Surgery to Remove Adrenocortical Oncocytic Carcinoma from an Asian Male with Scoliosis

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