18F-FDG PET-Derived Textural Indices Reflect Tissue-Specific Uptake Pattern in Non-Small Cell Lung Cancer

Orlhac, Fanny; Soussan, Michaël; Chouahnia, Kader; Martinod, Emmanuel; Buvat, Irène

doi:10.1371/journal.pone.0145063

Cited by 120 publications

(135 citation statements)

References 24 publications

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“…This region was supposed to be a homogeneous region of reference after systematic verification of the normal liver function [28]. Another parameter influencing textural feature values is the voxel size [29, 36].…”

Section: Methodsmentioning

confidence: 99%

Prediction of cervical cancer recurrence using textural features extracted from 18F-FDG PET images acquired with different scanners

et al. 2017

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ObjectivesTo identify an imaging signature predicting local recurrence for locally advanced cervical cancer (LACC) treated by chemoradiation and brachytherapy from baseline 18F-FDG PET images, and to evaluate the possibility of gathering images from two different PET scanners in a radiomic study.Methods118 patients were included retrospectively. Two groups (G1, G2) were defined according to the PET scanner used for image acquisition. Eleven radiomic features were extracted from delineated cervical tumors to evaluate: (i) the predictive value of features for local recurrence of LACC, (ii) their reproducibility as a function of the scanner within a hepatic reference volume, (iii) the impact of voxel size on feature values.ResultsEight features were statistically significant predictors of local recurrence in G1 (p < 0.05). The multivariate signature trained in G2 was validated in G1 (AUC=0.76, p<0.001) and identified local recurrence more accurately than SUVmax (p=0.022). Four features were significantly different between G1 and G2 in the liver. Spatial resampling was not sufficient to explain the stratification effect.ConclusionThis study showed that radiomic features could predict local recurrence of LACC better than SUVmax. Further investigation is needed before applying a model designed using data from one PET scanner to another.

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Section: Methodsmentioning

confidence: 99%

Prediction of cervical cancer recurrence using textural features extracted from 18F-FDG PET images acquired with different scanners

et al. 2017

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“…The segmentation methods currently offered are threshold-based methods accounting or not for background intensity and a click and draw option that creates a VOI from a seed point defined by the click using a region growing approach. (11,12). Quantization can also be performed in a range defined by the mean and standard deviation voxel values in the VOI.…”

Section: Segmentationmentioning

confidence: 99%

LIFEx: A Freeware for Radiomic Feature Calculation in Multimodality Imaging to Accelerate Advances in the Characterization of Tumor Heterogeneity

et al. 2018

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Textural and shape analysis is gaining considerable interest in medical imaging, particularly to identify parameters characterizing tumor heterogeneity and to feed radiomic models. Here, we present a free, multiplatform, and easy-to-use freeware called LIFEx, which enables the calculation of conventional, histogram-based, textural, and shape features from PET, SPECT, MR, CT, and US images, or from any combination of imaging modalities. The application does not require any programming skills and was developed for medical imaging professionals. The goal is that independent and multicenter evidence of the usefulness and limitations of radiomic features for characterization of tumor heterogeneity and subsequent patient management can be gathered. Many options are offered for interactive textural index calculation and for increasing the reproducibility among centers. The software already benefits from a large user community (more than 800 registered users), and interactions within that community are part of the development strategy. Significance: This study presents a user-friendly, multi-platform freeware to extract radiomic features from PET, SPECT, MR, CT, and US images, or any combination of imaging modalities. Cancer Res; 78(16); 4786–9. ©2018 AACR.

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“…These indices, if proven, could be used to reliably identify the existence of subpopulations of cells with distinct genomic alterations and could guide the choice of treatment, especially for targeted therapeutics (2). In PET, several retrospective studies suggest that texture indices reflect tumor heterogeneity and predict treatment response or patient survival whereas other studies underline the limitations of these indices (3)(4)(5)(6)(7)(8)(9). In addition, the interpretation of texture index values derived from PET images has never been reported, and texture indices have been investigated only in retrospective studies (10).…”

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Understanding Changes in Tumor Texture Indices in PET: A Comparison Between Visual Assessment and Index Values in Simulated and Patient Data

et al. 2016

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The use of texture indices to characterize tumor heterogeneity from PET images is being increasingly investigated in retrospective studies, yet the interpretation of PET-derived texture index values has not been thoroughly reported. Furthermore, the calculation of texture indices lacks a standardized methodology, making it difficult to compare published results. To allow for texture index value interpretation, we investigated the changes in value of 6 texture indices computed from simulated and real patient data. Methods: Ten sphere models mimicking different activity distribution patterns and the 18 F-FDG PET images from 54 patients with breast cancer were used. For each volume of interest, 6 texture indices were measured. The values of texture indices and how they changed as a function of the activity distribution were assessed and compared with the visual assessment of tumor heterogeneity. Results: Using the sphere models and real tumors, we identified 2 sets of texture indices reflecting different types of uptake heterogeneity. Set 1 included homogeneity, entropy, short-run emphasis, and long-run emphasis, all of which were sensitive to the presence of uptake heterogeneity but did not distinguish between hyper-and hyposignal within an otherwise uniform activity distribution. Set 2 comprised high-gray-level-zone emphasis and low-gray-level-zone emphasis, which were mostly sensitive to the average uptake rather than to the uptake local heterogeneity. Four of 6 texture indices significantly differed between homogeneous and heterogeneous lesions as defined by 2 nuclear medicine physicians (P , 0.05). All texture index values were sensitive to voxel size (variations up to 85.8% for the most homogeneous sphere models) and edge effects (variations up to 29.1%). Conclusion: Unlike a previous report, our study found that variations in texture indices were intuitive in the sphere models and real tumors: the most homogeneous uptake distribution exhibited the highest homogeneity and lowest entropy. Two families of texture index reflecting different types of uptake patterns were identified. Variability in texture index values as a function of voxel size and inclusion of tumor edges was demonstrated, calling for a standardized calculation methodology. This study provides guidance for nuclear medicine physicians in interpreting texture indices in future studies and clinical practice. Ani ncreasing number of studies focus on the characterization of tumor heterogeneity based on texture analysis from CT, MRI, ultrasound images, and, since 2009, PET images (1). The calculation of tumor heterogeneity indices from medical images offers the benefits of being noninvasive, accounting for the whole tumor, and being repeatable during treatment. These indices, if proven, could be used to reliably identify the existence of subpopulations of cells with distinct genomic alterations and could guide the choice of treatment, especially for targeted therapeutics (2). In PET, several retrospective studies suggest that texture indices reflect ...

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18F-FDG PET-Derived Textural Indices Reflect Tissue-Specific Uptake Pattern in Non-Small Cell Lung Cancer

Cited by 120 publications

References 24 publications

Prediction of cervical cancer recurrence using textural features extracted from 18F-FDG PET images acquired with different scanners

Prediction of cervical cancer recurrence using textural features extracted from 18F-FDG PET images acquired with different scanners

LIFEx: A Freeware for Radiomic Feature Calculation in Multimodality Imaging to Accelerate Advances in the Characterization of Tumor Heterogeneity

Understanding Changes in Tumor Texture Indices in PET: A Comparison Between Visual Assessment and Index Values in Simulated and Patient Data

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