18F-FDG PET-CT Simulation for Non–Small-Cell Lung Cancer: Effect in Patients Already Staged by PET-CT

Hanna, G.G.; McAleese, J.; Carson, K.J.; Stewart, David P.; Cosgrove, V.P.; Eakin, R.; Zatari, A.; Lynch, Tom; Jarritt, P. H.; Young, Vincent; O’Sullivan, Joe M.; Hounsell, Alan R.

doi:10.1016/j.ijrobp.2009.04.045

Cited by 40 publications

(32 citation statements)

References 19 publications

(38 reference statements)

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“…Eligible patients had a prior staging 18F-FDG PET/CT scan [3]. Included in this investigation were patients treated with radiation alone and having a maximum time of 9 weeks between staging and RTP PET/CT scans.…”

Section: Patient Selectionmentioning

confidence: 99%

“…N A manual PET contour (GTV PETMAN ) was generated following delineation using a standardised window setting, with the window width equal to the maximum of the pixel intensity within the target image and the window level equal to half this maximum [3].…”

Section: Target Volume Delineationmentioning

confidence: 99%

“…PET/CT imaging is also beneficial in radiotherapy treatment planning (RTP), for example by identifying metastases to mediastinal lymph nodes. PET/CT for RTP simulation has also been shown to reduce interobserver variation in gross tumour volume (GTV) delineation [2,3].…”

mentioning

confidence: 99%

“…This approach is superior to using CT alone for simulation, followed by visual correlation with PET [3]. However, acquiring a second PET/CT scan involves extra costs as well as increasing the radiation dose to the patient and the staff involved in the scanning procedure owing to the administration of a second dose of radiopharmaceutical [6].…”

mentioning

confidence: 99%

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Conventional 3D staging PET/CT in CT simulation for lung cancer: impact of rigid and deformable target volume alignments for radiotherapy treatment planning

Hanna

Koste

Carson³

et al. 2011

BJR

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Objective: Positron emission tomography (PET)/CT scans can improve target definition in radiotherapy for non-small cell lung cancer (NSCLC). As staging PET/CT scans are increasingly available, we evaluated different methods for co-registration of staging PET/CT data to radiotherapy simulation (RTP) scans. Methods: 10 patients underwent staging PET/CT followed by RTP PET/CT. On both scans, gross tumour volumes (GTVs) were delineated using CT (GTV CT ) and PET display settings. Four PET-based contours (manual delineation, two threshold methods and a source-to-background ratio method) were delineated. The CT component of the staging scan was co-registered using both rigid and deformable techniques to the CT component of RTP PET/CT. Subsequently rigid registration and deformation warps were used to transfer PET and CT contours from the staging scan to the RTP scan. Dice's similarity coefficient (DSC) was used to assess the registration accuracy of staging-based GTVs following both registration methods with the GTVs delineated on the RTP PET/CT scan. Results: When the GTV CT delineated on the staging scan after both rigid registration and deformation was compared with the GTV CT on the RTP scan, a significant improvement in overlap (registration) using deformation was observed (mean DSC 0.66 for rigid registration and 0.82 for deformable registration, p50.008). A similar comparison for PET contours revealed no significant improvement in overlap with the use of deformable registration. Conclusions: No consistent improvements in similarity measures were observed when deformable registration was used for transferring PET-based contours from a staging PET/CT. This suggests that currently the use of rigid registration remains the most appropriate method for RTP in NSCLC.

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Section: Patient Selectionmentioning

confidence: 99%

Section: Target Volume Delineationmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Conventional 3D staging PET/CT in CT simulation for lung cancer: impact of rigid and deformable target volume alignments for radiotherapy treatment planning

Hanna

Koste

Carson³

et al. 2011

BJR

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“…Several globally accepted atlases to aid TCD have also been published for sites such as head and neck cancer [13]. These resources have definitely improved TVD, but significant heterogeneity still exists, particularly with interpretation of functional imaging, such as is the case with positron computed tomography/computed tomography [5]. The Royal College of Radiologists and the European Society of Therapeutic Radiation Oncology also recognise the importance of accurate TVD and have created e-learning programs incorporating TVD modules using their 'COAST' and 'FALCON' platforms, respectively.…”

Section: Discussionmentioning

confidence: 99%