18F-FDG PET/CT diagnosis of liver cyst infection in a patient with autosomal dominant polycystic kidney disease and fever of unknown origin

Banzo, J.; Ubieto, M.A.; Gil, Daniel; Prats, E.; Razola, P.; Tardín, L.; Andrés, A.; Rambalde, E.F.; Ayala, Salomón; Cáncer, L.; Velilla, J.

doi:10.1016/j.remnie.2012.09.008

Cited by 2 publications

(4 citation statements)

References 9 publications

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“…The actual role of PET/CT is still not clear. A few reports described the role of PET in detecting cyst infection, either renal [9][10][11][12][13] or hepatic [14][15][16][17] or both [18][19][20][21], in patients with ADPKD, particularly recognizing …”

Section: Discussionmentioning

confidence: 99%

18F-FDG PET/CT demonstrated renal and hepatic cyst infection in a patient with autosomal dominant polycystic kidney disease

2016

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Infection of renal or hepatic cyst is a serious complication of autosomal dominant polycystic kidney disease (ADPKD) and early diagnosis is crucial for the correct management. We report a case of 64-year-old male with ADPKD, who required renal transplantation some years before, with recent recurrent episodes of fever and abdominal pain, who underwent 18 F-FDG PET/CT twice at 18 months intervals, after not conclusive conventional imaging studies (CT, ultrasonography).18 F-FDG PET/CT has proven to be a useful method for the diagnosis of renal and hepatic cyst infection in a patient with ADPKD and for the subsequent management.

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Section: Discussionmentioning

confidence: 99%

18F-FDG PET/CT demonstrated renal and hepatic cyst infection in a patient with autosomal dominant polycystic kidney disease

2016

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“…Recent studies have suggested positron emission computed tomography with 18 -fluorodeoxyglucose ( 18 FDG PET/CT) as the test of choice in the diagnosis of cystic infection. [164][165][166][167] 18FDG is a glucose analogue that accumulates inside inflammatory cells. In the presence of inflammatory processes, these cells, aiming to increase their metabolic rate, increase the expression of glucose receptors (GLUT-1 and GLUT-3) and the synthesis of enzymes involved in the glycolytic pathway, consequently increasing the uptake of 18 FDG.…”

Section: Diagnosismentioning

confidence: 99%

“…In the presence of inflammatory processes, these cells, aiming to increase their metabolic rate, increase the expression of glucose receptors (GLUT-1 and GLUT-3) and the synthesis of enzymes involved in the glycolytic pathway, consequently increasing the uptake of 18 FDG. 164,166,168 The sensitivity and specificity of 18 FDG PET/CT in the diagnosis of cystic infections are still unclear. The main advantages of 18 FDG PET/CT are speed in obtaining images, high target/background ratio, higher spatial resolution and low radiation dose, while its disadvantages include high cost and restricted availability.…”

Section: Diagnosismentioning

confidence: 99%

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Polycystic Liver Disease: Pathophysiology, Diagnosis and Treatment

Norcia¹,

Watanabe²,

Filho³

et al. 2022

HMER

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Polycystic liver disease (PLD) is a clinical condition characterized by the presence of more than 10 cysts in the liver. It is a rare disease Of genetic etiology that presents as an isolated disease or assoc\iated with polycystic kidney disease. Ductal plate malformation, ciliary dysfunction, and changes in cell signaling are the main factors involved in its pathogenesis. Most patients with PLD are asymptomatic, but in 2-5% of cases the disease has disabling symptoms and a significant reduction in quality of life. The diagnosis is based on family history of hepatic and/or renal polycystic disease, clinical manifestations, patient age, and polycystic liver phenotype shown on imaging examinations. PLD treatment has evolved considerably in the last decades. Somatostatin analogues hold promise in controlling disease progression, but liver transplantation remains a unique curative treatment modality.

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18F-FDG PET/CT diagnosis of liver cyst infection in a patient with autosomal dominant polycystic kidney disease and fever of unknown origin

Cited by 2 publications

References 9 publications

18F-FDG PET/CT demonstrated renal and hepatic cyst infection in a patient with autosomal dominant polycystic kidney disease

18F-FDG PET/CT demonstrated renal and hepatic cyst infection in a patient with autosomal dominant polycystic kidney disease

Polycystic Liver Disease: Pathophysiology, Diagnosis and Treatment

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