18F-2-deoxy-2-fluoro-D-glucose uptake into human tumor xenografts. Feasibility studies for cancer imaging with positron-emission tomography

Abstract

The positron-emitting glucose analogue l8F-2-fluoro-2-deoxy-d-g1ucose (FDG) was evaluated for its accretion into the following subcutaneous human tumor xenografts in nude mice: B-cell lymphoma (Namalwa or Raji), ovarian carcinoma (HTB77), colon cancer (SW948), choriocarcinoma (BEWO), bladder cancer (UM-UC-2), renal cell carcinoma (UM-RC-3), neuroblastoma (Mey), melanoma (HTB63), and small cell lung carcinoma (NCI69). Two hours postinjection, tumor uptakes ranged from 0.027 (colon cancer) to 0.125% kg injected dose/g (melanoma); and was greater than 0.085 in the Namalwa lymphomas and the renal cell carcinomas. Tumor-blood ratios of up to 23:l were seen 2 hours postinjection (melanoma) with a mean tumor-blood ratio for all tumors of 12.3 + 1.8. Uptake in the other tumors was intermediate. When evaluated, tumor uptake was slightly greater at 1 than at 2 hours postinjection, although target-background ratios were generally higher at 2 hours postinjection. This compound, FDG, may have broad applicability as a tracer for positron-emission tomographic imaging of many human malignancies. Cancer 67:1544-1550,1991, NONINVASIVE METHOD to detect and localize tU-A mors accurately for staging purposes and to replicably quantitate their metabolic activity would be of great clinical value. Positron-emission tomography (PET), a nuclear-medicine technique detecting the dual-emission of annihilation photons (from the interaction of positrons with electrons) after nuclear decay of a positron-emitting labeled tracer, has the potential to be such a technique, due to its quantitative tomographic imaging capabilities and excellent resolution.' Although PET scanning has From the

Oncological applications of positron emission tomography with fluorine-18 fluorodeoxyglucose

“…In animals, melanoma is one of the tumours with the highest glycolytic metabolism and FDG uptake [263]. Initial evaluation confirms the high sensitivity of FDG PET in detecting melanoma lesions.…”

Role of PET/CT in the detection of liver metastases from colorectal cancer

“…Numerous studies have shown that rapidly growing neoplastic tissue utilises glucose as a substrate for energy needs, thus producing an increased uptake of 18 F-FDG [15]. Even though the tracer is not tumour-cell specific, 18 F-FDG is widely used in the study of many malignant diseases [16,17], as it is considered better than conventional imaging in identifying primary or secondary tumours.…”

“…Indeed, studies have shown that the reduction in the number of malignant cells fini energetici, determinando un aumento dell'uptake del 18 F-FDG [15]. Sebbene tale tracciante non sia specifico della cellula tumorale, la 18 F-FDG-PET risulta largamente utilizzata nello studio di molte patologie neoplastiche [16,17] Nel nostro studio, le metodiche mostrano una concordanza con valori di sensibilità, specificità ed accuratezza superiori ai dati della letteratura poiché, la maggior parte degli studi finora effettuati utilizzano la TC senza la somministrazione di MdC organo-iodato, che non permette la visualizzazione di molte metastasi epatiche [17][18][19].…”

Evaluation of 2-[18F]-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography in rat models with hepatocellular carcinoma with liver cirrhosis

“…Positron emission tomography (PET)/computed tomography (CT) are nuclear imaging modalities that have been widely used to investigate cancer [7,8]. PET imaging provides information on the metabolic alterations in masses.…”