189d. Funktionell-klinische Untersuchungen der Lunge im Schock

Zimmermann, W. E.; Walter, Franziska; Vogel, Walther; Mittermayer, Ch.

doi:10.1007/bf01770618

Cited by 13 publications

(2 citation statements)

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“…The acidosis of the CSF stands in a reversed relation to its bicarbonate (Zimmermann 1964-, Siesj5 1968, Leusen 1968, Zwetnow 1969, Kaasik and Zupping 1969. Therefore any decrease or increase in the CSF pH indicates that the physiological compensating mechanisms can no longer guarantee a constant pH.…”

Section: Discussionmentioning

confidence: 97%

The prognostic and therapeutic importance of changes in the CSF during the acute stage of brain injury

Seitz

Ocker

1977

Acta neurochir

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This research deals with the gaseous and biochemical changes in the cerebrospinal fluid and their effects on the cerebral blood flow and metabolic rates in the acute stage of brain injury. The results have shown that the lactacidosis in the CSF is of importance for prognosis and therapy, because of its central position in the course of pathophysiological mechanisms after a traumatic brain injury. Thus the lactate concentration in the CSF does give early information about the further clinical course. CSF acidosis itself can be influenced in a favourable way by intrathecal therapy with sodium bicarbonate.

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Section: Discussionmentioning

confidence: 97%

The prognostic and therapeutic importance of changes in the CSF during the acute stage of brain injury

Seitz

Ocker

1977

Acta neurochir

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“…Many of the pathological changes described in the lungs after extracorporeal circulation are frequently found in shock lungs (4,6,20,21,25,29), and less often in the lungs following oxygen intoxication (8,11) and blood transfusion (27). The lungs therefore react stereotypically to different forms of assault.…”

Section: Discussionmentioning

confidence: 99%

Ultrastructural changes in the human lung following cardiopulmonary bypass

et al. 1982

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In order to assess the degree of the pathological changes presenting in the lungs of patients after elective cardiac operations in cardiopulmonary bypass and to determine their prognosis, lung biopsies were taken from the right lower lobe of 36 patients after extracorporeal circulation and studied ultrastructurally. Prepump biopsies from the same presenting anterior portion of the lower lobe of the lung served as controls. Perivascular and interstitial edema featured prominently. Intraalveolar edema and extravasated corpuscular blood elements were observed, too. Damages to the mitochondria and to the lamellar bodies and swelling of the endothelial and alveolar cells were major observations following cardiopulmonary bypass lasting more than 60 minutes. These changes were also prominent in those lungs presenting with severe edema and fibrosis. Many intact type-II pneumocytes presented with enhanced metabolic and secretory activities. Merocrine and apocrine secretions were observed after extracorporeal circulation. The alveoli of the postpump lungs contained numerous detached normal appearing type-II pneumocytes, in contrast to the paucity of such cells in the alveoli of the control biopsies. The prognosis for the patients depends on any one or combination of any of the following factors: the pathological changes present in the lungs prior to the extracorporeal circulation, the duration of the cardiopulmonary bypass, the rate of the elimination of the surfactant and finally the ability of the undamaged type-II pneumocytes to step up the synthesis and secretion of the surface acting agent.

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