18‐Crown‐6 Catalyzed Microwave‐mediated Synthesis of Symmetric Bis‐Heterocyclic Compounds under Solvent‐free Condition

Abstract

An efficient, solvent‐free and 18‐crown‐6 catalyzed method for the synthesis of N‐alkyl‐4‐(4‐(5‐(2‐(alkyl‐amino)thiazol‐4‐yl)pyridin‐3‐yl)phenyl)thiazol‐2‐amine, N‐alkyl‐4‐(5‐(2‐alkyamino)thiazol‐4‐yl)pyridine‐3‐yl)thiazol‐2‐amine, and 4,4′‐bis‐{2‐[amino]‐4‐thiazolyl}biphenyl bis‐heterocyclic derivatives via microwave accelerated cyclization is presented.

Electrochemical Reduction of α-Diketones and α-Diimines in the Presence of a Bielectrophilic Substrate: Synthesis of New Aza-Crown Compounds

“…All products were characterized by 1 H and 13 C NMR spectroscopy, IR spectroscopy, EI mass spectrometry and elemental analysis. [1,7]dioxa [4]…”

“…6 These compounds are also used as catalysts in organic synthesis (18-crown 6). 7 The replacement of oxygen atoms by nitrogen atoms improves the complexing property of crown ethers and affects their selectivity for metals. 8 Consequently, aza-crown ethers constitute an important class of macrocylic complexing compounds, due to their nitrogen lone pairs and N-H moieties, rendering them able to complex both cations and anions, depending on the pH value of the aqueous solution.…”

Synthesis of some novel piperidine fused 5-thioxo-1H-1,2,4-triazoles as potential antimicrobial and antitubercular agents

“…As a part of our continued research work on the synthesis of potentially active molecules for medicinal chemistry screening, [19][20][21][22][23][24] and for the development of new antimicrobial and antitubercular agents, [25][26][27][28][29] it was planned to introduce piperidine fused 5-thioxo-1H-1,2,4-triazole molecule using electronically diverse aryl groups. A detailed literature survey revealed the fact that the synthesis of such fused 1,2,4triazole derivatives containing thioxo group requires the use of semicarbazides or carbon disulphide in hydrazine.…”