Electrochemical Reduction of α-Diketones and α-Diimines in the Presence of a Bielectrophilic Substrate: Synthesis of New Aza-Crown Compounds

Medini, Hayet; Mekni, Nejib Hussein; Aoun, Sami Ben; Boujlel, Khaled

doi:10.1149/2.0871702jes

Cited by 2 publications

(1 citation statement)

References 28 publications

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“…14 It should be noted that voltammetry is widely applied in pharmaceutical research as it offers accurate, sensitive, efficient, and simple analytical tools using low-cost equipment and procedures. 15,16 Moreover, it not only affords an analytical methodology, but also enables the study of electrode reaction kinetics 17,18 and elucidates the nature of the peak current.…”

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confidence: 99%

Nanomaterials vs Amalgam in Electroanalysis: Comparative Electrochemical Studies of Lamotrigine

Smarzewska

Guziejewski

Leniart

et al. 2017

J. Electrochem. Soc.

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This paper reports a comparative study of electrochemical oxidation and reduction of lamotrigine (LMT) at a modified glassy carbon electrode (MWCNT/RGO–GCE) and a cyclic renewable silver amalgam film electrode (Hg(Ag)FE). Therefore, square wave voltammetry was employed to enable comparison of electrode mechanisms and analytical responses by analysis of voltammetric signals. The analytical performance of both electrodes, including quantification and detection limits, recovery, and reproducibility, was evaluated. The prepared sensors showed good sensitivity and selectivity for LMT determination in pharmaceutical formulations and urine samples. The results indicated that both of the tested electrodes and the developed methods can be considered as suitable tools and interesting alternatives in terms of analytical determination of lamotrigine. It was also stated that the recorded reduction signal is a consequence of two-electron process involving reduction of the azo group, while the oxidation peak is attributed to grafting and further dimerization of LMT molecules. AFM microscopy was used to characterize the modified electrode structure.

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confidence: 99%