This paper presents a low-noise chopper-stabilized zero-drift amplifier with successive approximation register (SAR)-assisted automatic offset calibration loop (AOCL). The amplifier is designed using multipath zero-drift architecture including a low frequency path (LFP) and a high frequency path (HFP). The multipath architecture can achieve the low offset, the low noise and the low drift while maintaining the wide bandwidth. The LFP amplifier exploits a chopper scheme to reduce the offset and the low-frequency noise components. The digitally assisted AOCLs in the LFP and the HFP using SAR and current-mode digital-to-analog converter (DAC) can reduce the offset coarsely. The mismatch and the offset of the LFP amplifier can generate the up-modulated output ripples. The residual ripples in the LFP can be reduced using a ripple reduction loop (RRL). To prevent secondary ripple caused by the offset of the RRL itself, an autozero (AZ) integrator is employed. The HFP amplifier is designed using the folded-cascode structure with class-AB output stage to enhance the power efficiency. The multipath amplifier is fabricated in a 0.18 μm CMOS process. The current consumption, supply voltage and active area are 130 μA, 1.8 V and 0.86 mm 2 , respectively. The amplifier has a unit gain bandwidth (UGBW) of 0.875 MHz, an input referred offset of 4.6 μV, an input referred noise of 25.6 nV/√Hz, an offset drift of 53 nV/℃ and a noise efficiency factor (NEF) of 11.2.INDEX TERMS Multipath amplifier, ripple reduction, automatic offset calibration loop (AOCL), SAR.