17β-Estradiol infusions into the dorsal striatum rapidly increase dorsal striatal dopamine release in vivo

Shams, Waqqas M.; Sanio, Christian; Quinlan, Matthew G.; Brake, Wayne G.

doi:10.1016/j.neuroscience.2016.05.049

Cited by 33 publications

(26 citation statements)

References 35 publications

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“…The outcome of meta‐analysis and forest plot of basal dopamine levels (nM) in caudate putamen of 272 female rats. While in both brain regions the data show considerable heterogeneity I 2 = 98%, the pattern of data distribution among included studies for caudate putamen (Robinson and Camp, ; Maisonneuve, et al, ; Robinson and Camp, ; Maisonneuve and Glick, ; Blanchard, et al, ; Blanchard, et al, ; Blanchard and Glick, ; Pearl, et al, ; Becker and Rudick, ; Maisonneuve and Glick, ; Cummings, et al, ; Shams, et al, ) indicates that the year of publication is a critical factor. In particular, studies published before 1995 report significantly ( p < 0.0001) different basal dopamine levels that are in average approximately eightfold higher than publications in the following years.…”

Section: Resultsmentioning

confidence: 98%

“…Data of 232 female rats were provided from 12 original studies (Robinson, et al, ; Becker and Cha, ; Robinson and Camp, ; Robinson and Camp, ; Maisonneuve and Glick, ; Castner, et al, ; Glick, et al, ; Becker and Rudick, ; Shoblock, et al, ; Geiger, et al, ; McCallum, et al, ; Shams, et al, ). Two‐step cluster analysis suggests that psychostimulants, particularly amphetamines, induce the strongest impact on dopamine levels in striatum.…”

Section: Resultsmentioning

confidence: 99%

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No basal or drug‐induced sex differences in striatal dopaminergic levels: a cluster and meta‐analysis of rat microdialysis studies

Egenrieder

Mitricheva

Spanagel

et al. 2019

Journal of Neurochemistry

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Sex differences in behavioural patterns of drug abuse and dependence have been hypothesized to be a consequence of sexual dimorphisms in brain pathways, particularly within the dopaminergic reward circuitry. Yet, how potential sex differences are manifested at a neurochemical level remains unclear. Here, we use a meta‐analysis approach to investigate whether animal studies robustly indicate a different regulation of striatal dopamine transmission in males and females. Data from 39 microdialysis experiments on female rats (n = 676) were extracted and statistically compared with data from 1523 male rats. All drugs of abuse, independent of their molecular mechanisms of action, notably increase extracellular dopamine concentrations in the nucleus accumbens (NAc) and caudate putamen (CPu). No significant sex differences in basal levels or in dopaminergic response to drugs of abuse were found. However, basal dopamine levels in CPu (but not NAc) were significantly altered by ovariectomy. In conclusion, there are no sex‐dependent differences in basal dopamine levels within the NAc and CPu. Previously reported sex differences in the CPu seem to be a result of ovariectomy and may only to a lesser, non‐significant degree be attributed to a sexual duality.

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Section: Resultsmentioning

confidence: 98%

Section: Resultsmentioning

confidence: 99%

No basal or drug‐induced sex differences in striatal dopaminergic levels: a cluster and meta‐analysis of rat microdialysis studies

Egenrieder

Mitricheva

Spanagel

et al. 2019

Journal of Neurochemistry

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“…Other hormonal effects may contribute to the sexual dimorphism. For example, estradiol modulates striatal DA release and CIN activity (65, 66). Allopregnanolone, a metabolite of progesterone, enhances GABAergic neurotransmission through positive allosteric modulation of GABA A receptors (67).…”

Section: Discussionmentioning

confidence: 99%

Targeted Interneuron Depletion in the Dorsal Striatum Produces Autism-like Behavioral Abnormalities in Male but Not Female Mice

Rapanelli

Frick

et al. 2017

Biological Psychiatry

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Background Interneuronal pathology is implicated in many neuropsychiatric disorders, including autism spectrum disorder (ASD) and Tourette syndrome (TS). Interneurons of the striatum, including the parvalbumin-expressing fast-spiking interneurons (FSIs) and the large cholinergic interneurons (CINs), are affected in patients with TS and in preclinical models of both ASD and TS. Methods To test the causal importance of these neuronal abnormalities, we have recapitulated them in vivo in developmentally normal mice, using a combination transgenic-viral strategy for targeted toxin-mediated ablation. Results We find that conjoint ~40% depletion of FSIs and CINs in the dorsal striatum of male mice produces spontaneous stereotypy and marked deficits in social interaction. Strikingly, these behavioral effects are not seen in female mice; since ASD and TS have a marked male predominance, this observation reinforces the potential relevance of this finding to human disease. Neither of these effects is seen when only one or the other interneuronal population is depleted; ablation of both is required. Depletion of FSIs, but not of CINs, also produces anxiety-like behavior, as has been described previously. Behavioral pathology in males after conjoint FSI and CIN depletion is accompanied by increases in activity-dependent signaling in the dorsal striatum; these alterations were not observed after disruption of only one interneuron type, or in doubly-depleted females. Conclusions These data indicate that disruption of CIN and FSI interneurons in the dorsal striatum is sufficient to produce network and behavioral changes of potential relevance to ASD, in a sexually dimorphic manner.

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“…However, baseline ventral tegmental area activity and phasic dopamine release is similar between the sexes in the nucleus accumbens [118]. Electrically stimulated phasic dopamine release is higher in estrous females (when estradiol levels are high) compared to males or females in low-estradiol stages [100,101,103,118]. [8] Estrous-associated increases in ventral tegmental area firing and dopamine release increase phosphorylation of DAT at threonine 53 (Thr53), which increases the affinity of cocaine for DAT.…”

Section: Key Playersmentioning

confidence: 99%

“…In females, extracellular dopamine varies with the estrous cycle [97] and is dependent on the actions of estradiol in the striatum. Estradiol acts directly in dorsal striatum to enhance stimulated dopamine release in OVX female, but not CAST male rats [97,[99][100][101][102]. In possible contrast to the above results using microdialysis, which provides a slower time course of extracellular dopamine release, in vivo and in vitro experiments in rats using fast scan cyclic voltammetry, which measures phasic dopamine release in real time, has shown that electrical stimulation of the ventral tegmental area and cocaine-induced dopamine release and uptake rates are greater in the female, compared to the male, striatum-regardless of estrous cycle stage, which may underlie the lower basal dopamine concentrations found with microdialysis [103].…”

Section: Key Playersmentioning

confidence: 99%

Sex differences in neural mechanisms mediating reward and addiction

Becker

Chartoff

2018

Neuropsychopharmacol

355

251

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There is increasing evidence in humans and laboratory animals for biologically based sex differences in every phase of drug addiction: acute reinforcing effects, transition from occasional to compulsive use, withdrawal-associated negative affective states, craving, and relapse. There is also evidence that many qualitative aspects of the addiction phases do not differ significantly between males and females, but one sex may be more likely to exhibit a trait than the other, resulting in population differences. The conceptual framework of this review is to focus on hormonal, chromosomal, and epigenetic organizational and contingent, sex-dependent mechanisms of four neural systems that are known-primarily in males-to be key players in addiction: dopamine, mu-opioid receptors (MOR), kappa opioid receptors (KOR), and brain-derived neurotrophic factor (BDNF). We highlight data demonstrating sex differences in development, expression, and function of these neural systems as they relate-directly or indirectly-to processes of reward and addictive behavior, with a focus on psychostimulants and opioids. We identify gaps in knowledge about how these neural systems interact with sex to influence addictive behavior, emphasizing throughout that the impact of sex can be highly nuanced and male/female data should be reported regardless of the outcome.

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17β-Estradiol infusions into the dorsal striatum rapidly increase dorsal striatal dopamine release in vivo

Cited by 33 publications

References 35 publications

No basal or drug‐induced sex differences in striatal dopaminergic levels: a cluster and meta‐analysis of rat microdialysis studies

No basal or drug‐induced sex differences in striatal dopaminergic levels: a cluster and meta‐analysis of rat microdialysis studies

Targeted Interneuron Depletion in the Dorsal Striatum Produces Autism-like Behavioral Abnormalities in Male but Not Female Mice

Sex differences in neural mechanisms mediating reward and addiction

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