No basal or drug‐induced sex differences in striatal dopaminergic levels: a cluster and meta‐analysis of rat microdialysis studies

Egenrieder, Lisamon; Mitricheva, Ekaterina; Spanagel, Rainer; Noori, Hamid

doi:10.1111/jnc.14911

Cited by 22 publications

(12 citation statements)

References 72 publications

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“…However, one must exercise caution generalizing the findings from ovariectomized females to intact females, as there are no sex differences in basal dopamine levels as measured by no net flux microdialysis within intact subjects [26]. Furthermore, a meta-analysis of microdialysis research concludes no basal or druginduced sex differences in striatal dopamine [43]. As such, it is unlikely that any potential basal differences in dopamine levels between sexes could account for the stimulus-specific sex differences in rapid dopamine transmission.…”

Section: Discussionmentioning

confidence: 99%

Sex differences in behavioral responding and dopamine release during Pavlovian learning

Lefner

Dejeux

Wanat

2021

Preprint

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Learning associations between cues and rewards requires the mesolimbic dopamine system. The dopamine response to cues signals differences in reward value in well-trained animals. These value-related dopamine responses are absent during early learning when cues signal differences in the reward rate, which suggests cue-evoked dopamine release conveys differences between outcomes only after extensive training. However, it is unclear if this lack of value coding by cue-evoked dopamine release during early learning is unique to when cues signal differences in reward rate, or if this is also evident when cues signal differences in other value-related parameters such as reward size. To address this, we utilized a Pavlovian conditioning task in which one audio cue was associated with a small reward (one pellet) and another audio cue was associated with a large reward (three pellets). We performed fast-scan cyclic voltammetry to record changes in dopamine release in the nucleus accumbens of male and female rats throughout early learning. Cue-evoked dopamine release did not encode differences in reward value, and there were no differences in this response between males and females. However, female rats exhibited higher levels of conditioned responding and a faster latency to respond. Reward-evoked dopamine release scaled with reward size in both sexes, though there were transient sex differences in the dynamics of this response. We additionally identified sex differences in the number of post-reward head entries. Collectively these data illustrate sustained sex differences in behavioral responding as well as transient sex differences in reward-evoked dopamine release.

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Section: Discussionmentioning

confidence: 99%

Sex differences in behavioral responding and dopamine release during Pavlovian learning

Lefner

Dejeux

Wanat

2021

Preprint

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“…Furthermore, in a recent systematic review by Egenrieder et al. (2020), these authors also did not observe significant differences between males and females; neither relates to the basal levels of dopamine found in the striatum nor the effects produced by the administration of drugs of abuse.…”

Section: Methodsmentioning

confidence: 87%

Participation of glutamatergic and nitrergic systems in the striatal dopamine release induced by isatin, a MAO inhibitor

Faro

Justo

Gómez

et al. 2021

Eur J of Neuroscience

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Isatin is a biofactor with different biochemical and pharmacological properties whose effects attract much attention because it is an endogenous inhibitor of the monoamine oxidase in the brain. When exogenously administrated, isatin increases dopamine levels in intact and denervated striatum of rats, an effect that could indicate its potential as a therapeutic agent in Parkinson disease. However, the neurochemical mechanisms by which isatin increases dopamine in the striatum are poorly understood. In the present study, we evaluate the role of the glutamatergic and nitrergic systems in the isatin‐induced dopamine release from rat striatum. Our findings show that the intrastriatal administration of 10 mM isatin significantly increases the in vivo release of dopamine (1,104.7% ± 97.1%), and the amino acids glutamate (428.7% ± 127%) and taurine (221% ± 22%) from rat striatum measured by brain microdialysis. The pretreatment with MK‐801 (500 µM) or AP5 (650 µM) (glutamatergic NMDA receptors antagonists) significantly reduces the effect of isatin on dopamine release by 52% and 70.5%, respectively. The administration of the nitric oxide synthase inhibitors, L‐NAME (100 µM) or 7‐NI (100 µM) also decreases the isatin‐induced dopamine release by 77% and 42%, respectively. These results show that isatin, in addition to increasing dopamine release, also increases glutamate levels, and possibly activates NMDA receptors and nitric oxide production, which can promote a further increase in the dopamine release.

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“…In particular, if all included studies included in the analysis are reporting an estimate of the same effect and our goal is to calculate the overall effect size for the identified population without generalization to other populations, then a fixed effect model is more appropriate. 29 , 30 In the present study, we compute random effect weighted averages for subgroups with minimized level of heterogeneity in experimental design, e.g. meta-analysis of the changes in a particular neurotransmitter such as glutamate in a specific brain region such as prefrontal cortex following a specific dosage of a drug.…”

Section: Methodsmentioning

confidence: 99%

Neurochemical underpinning of hemodynamic response to neuropsychiatric drugs: A meta- and cluster analysis of preclinical studies

Mervin

Mitricheva

Logothetis

et al. 2020

J Cereb Blood Flow Metab

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Functional magnetic resonance imaging (fMRI) is an extensively used method for the investigation of normal and pathological brain function. In particular, fMRI has been used to characterize spatiotemporal hemodynamic response to pharmacological challenges as a non-invasive readout of neuronal activity. However, the mechanisms underlying regional signal changes are yet unclear. In this study, we use a meta-analytic approach to converge data from microdialysis experiments with relative cerebral blood volume (rCBV) changes following acute administration of neuropsychiatric drugs in adult male rats. At whole-brain level, the functional response patterns show very weak correlation with neurochemical alterations, while for numerous brain areas a strong positive correlation with noradrenaline release exists. At a local scale of individual brain regions, the rCBV response to neurotransmitters is anatomically heterogeneous and, importantly, based on a complex interplay of different neurotransmitters that often exert opposing effects, thus providing a mechanism for regulating and fine tuning hemodynamic responses in specific regions.

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No basal or drug‐induced sex differences in striatal dopaminergic levels: a cluster and meta‐analysis of rat microdialysis studies

Cited by 22 publications

References 72 publications

Sex differences in behavioral responding and dopamine release during Pavlovian learning

Sex differences in behavioral responding and dopamine release during Pavlovian learning

Participation of glutamatergic and nitrergic systems in the striatal dopamine release induced by isatin, a MAO inhibitor

Neurochemical underpinning of hemodynamic response to neuropsychiatric drugs: A meta- and cluster analysis of preclinical studies

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