17β-Estradiol and the glucocorticoid clobetasol propionate affect the blood coagulation cascade in zebrafish

Schmid, Simon; Fent, Karl

doi:10.1016/j.envpol.2019.113808

Cited by 8 publications

(1 citation statement)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While their relation to estrogen response is unknown, aqp12 has been shown to be altered when zebrafish were exposed to estrogenic compounds (Lam et al, 2008). Lastly, serpin genes have been shown to be estrogen responsive; however, there is currently conflicting data on whether serpinc1 specifically is estrogen responsive (Hao et al, 2013;Saili et al, 2013;Schmid & Fent, 2020). These results suggest that despite the poor sequencing quality, the methodology was sensitive enough that a weak estrogenic response was detected.…”

Section: Tgsh Induced Estrogenic and Cholesterol Related Responsesmentioning

confidence: 99%

Transcriptomic Dose-Response Analysis in Zebrafish Embryos to Estimate Aquatic Toxicity of Plasticizers and Plastic Monomers

Nguyen¹

View full text Add to dashboard Cite

Current toxicity tests have high monetary costs, efficiency issues and ethical concerns.New approach methodologies, such as transcriptomic dose response modelling (TDRM), are increasingly being used to address these issues. This thesis aimed to combine the TDRM method with an acute zebrafish embryo model exposure to determine effective concentrations for chemicals of concern (plasticizers and plastic monomers). We hypothesized that the TDRM methodology would be more sensitive and informative than traditional apical endpoints derived from acute fish exposures. We found that transcriptomic endpoints were more sensitive than apical endpoints for the majority of chemicals tested. However, several challenges related to experimental design and RNA sequencing were encountered and recommendations were given for future studies to address these challenges. Overall, the TDRM methodology, when combined with the zebrafish embryo model, shows promise as an effective tool for screening and prioritizing chemicals of concern. Research Centre (NWRC). I've had the pleasure to work on many amazing projects, meet amazing people and have had countless amazing experiences both inside and outside the lab all thanks to them. Their unique skills sets, and decades of combined experience helped me broaden my horizons and shaped me to be the researcher and person that I am today.

show abstract

Section: Tgsh Induced Estrogenic and Cholesterol Related Responsesmentioning

confidence: 99%

Transcriptomic Dose-Response Analysis in Zebrafish Embryos to Estimate Aquatic Toxicity of Plasticizers and Plastic Monomers

Nguyen¹

View full text Add to dashboard Cite

show abstract

Effects of environmental steroid mixtures are regulated by individual steroid receptor signaling

2020

View full text Add to dashboard Cite

Development of a portable electroanalytical method using nickel modified screen-printed carbon electrode for ethinylestradiol determination in organic fertilizers

Silva

Rodrigues

Franco

et al. 2021

Ecotoxicology and Environmental Safety

View full text Add to dashboard Cite

17β-Estradiol and the glucocorticoid clobetasol propionate affect the blood coagulation cascade in zebrafish

Cited by 8 publications

References 46 publications

Transcriptomic Dose-Response Analysis in Zebrafish Embryos to Estimate Aquatic Toxicity of Plasticizers and Plastic Monomers

Transcriptomic Dose-Response Analysis in Zebrafish Embryos to Estimate Aquatic Toxicity of Plasticizers and Plastic Monomers

Effects of environmental steroid mixtures are regulated by individual steroid receptor signaling

Development of a portable electroanalytical method using nickel modified screen-printed carbon electrode for ethinylestradiol determination in organic fertilizers

Contact Info

Product

Resources

About