17-β estradiol in the acetylcholinesterase activity and lipid peroxidation in the brain and blood of ovariectomized adult and middle-aged rats

Martins, Danieli Brolo; Mazzanti, Cinthia M.; França, Raqueli Teresinha; Pagnoncelli, Marciélen; Costa, Márcio Machado; Souza, Estevan Martins de; Gonçalves, Jamile Fabbrin; Spanevello, Rosélia Maria; Schmatz, Roberta; Costa, Pauline da; Mazzantí, Alexandre; Beckmann, Diego Vilibaldo; Cecim, Marcelo; Schetinger, Maria Rosa Chitolina; Lopes, Sônia Terezinha dos Anjos

doi:10.1016/j.lfs.2011.12.006

Cited by 20 publications

(11 citation statements)

References 62 publications

(104 reference statements)

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“…A selective ER-b agonist more markedly reduced (52.5%) this activity toward reference levels in Ovx-Dia rats than did E 2 (40.2%) and an ER-a agonist (21.1%). These results corroborate previous studies which found that treatment with estradiol decreases acetylcholinesterase activity in the brain of ovariectomized 46 and diabetic 48 rats. A study by Huang and Zhang 49 reported that 7-O-modified genistein, a selective ER-b agonist, showed anticholinesterase activity in ovariectomized rats.…”

Section: Er Agonists In Postmenopausal Diabetessupporting

confidence: 93%

“…47 Acetylcholinesterase, a surrogate marker of dementia, is increased after menopause and diabetes. 46,48 We also observed a significant increase in acetylcholinesterase activity (58.2%) in Ovx-Dia rats compared with their respective controls. A selective ER-b agonist more markedly reduced (52.5%) this activity toward reference levels in Ovx-Dia rats than did E 2 (40.2%) and an ER-a agonist (21.1%).…”

Section: Er Agonists In Postmenopausal Diabetessupporting

confidence: 55%

“…46 These cholinergic projections play an important role in neuronal plasticity and cognitive performance. Moreover, cholinergic neurons are markedly affected by changes in circulating levels of estrogen.…”

Section: Er Agonists In Postmenopausal Diabetesmentioning

confidence: 99%

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Differential role of estrogen receptor modulators in depression-like behavior and memory impairment in rats with postmenopausal diabetes

Bansal

Chopra

2015

Menopause

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Section: Er Agonists In Postmenopausal Diabetessupporting

confidence: 93%

Section: Er Agonists In Postmenopausal Diabetessupporting

confidence: 55%

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Differential role of estrogen receptor modulators in depression-like behavior and memory impairment in rats with postmenopausal diabetes

Bansal

Chopra

2015

Menopause

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“…Measure of the AChE activity can provide an evidence, at least indirectly, of how the concentration of Ach is in the brain [30]. One recent research result showed that AChE in striatum of rats that received bilateral ovariectomy was activated [31]. Our results demonstrated that the activity and expression of AChE in hippocampus of OVX animals were both increased compared with control animals.…”

Section: Discussionsupporting

confidence: 57%

Effects of puerarin on cholinergic enzymes in the brain of ovariectomized guinea pigs

Zhang¹,

Chen²,

Ye³

et al. 2013

International Journal of Neuroscience

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Estrogen has beneficial effects on neurodegenerative disorders and cognitive function of postmenopausal women. Puerarin, isolated from Pueraria lobota, has been classified as a phytoestrogen, which can be highly effective against cerebrovascular diseases. In this study, the effects of puerarin on neural cholinergic system in the brain of ovariectomized guinea pigs were studied. The puerarin at the doses used (15 mg/kg body weight (bw)/day and 30 mg/kg bw/day) for 10 days had the estrogenic activity indicated by the attenuation of the reduction of uterine weight induced by ovariectomy. In brain, puerarin treatment increased choline acetyltransferase (ChAT) activity and expression in hippocampus, and increased ChAT immnuopositive signals in septal diagonal region. Puerarin treatment could suppress the increase of acetylcholinesterase expression and activity to the levels of the intact group, although they were not significantly different from those of the ovariectomized animals. Moreover, puerarin decreased the β-amyloid immunopositive staining in hippocampus. In brief, the present study suggests that puerarin prevents the dysfunction of the neuronal cholinergic system and ameliorates the increase of β-amyloid caused by estrogen deficiency.

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“…During ageing (Rastogi et al 2012) and ovariectomy (Martins et al 2012), the enhanced generation of ROS induced chronic oxidative stress in the brain. This condition caused gradual accumulation of damaged proteins leading to a functional decline in the brain's endogenous defence system (Rumora et al 2007;Min et al 2008) and leading to the activation of stress kinases (JNK and p38 MAPK) (Gabai et al 1997).…”

Section: Discussionmentioning

confidence: 99%

Melatonin and oestrogen treatments were able to improve neuroinflammation and apoptotic processes in dentate gyrus of old ovariectomized female rats

Kireev

Vara

Viña

et al. 2014

AGE

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The aim of this study was to determine the outcomes of oestrogen and melatonin treatments following long-term ovarian hormone depletion on neuroinflammation and apoptotic processes in dentate gyrus of hippocampi. Forty-six female Wistar rats of 22 months of age were used. Twelve of them remained intact, and the other 34 were ovariectomized at 12 months of age. Ovariectomized animals were divided into three groups and treated for 10 weeks with oestrogens, melatonin or saline. All rats were killed by decapitation at 24 months of age, and dentate gyri were collected. A group of 2 month-old intact female rats was used as young control. The levels of pro-inflammatory cytokines and heat shock protein 70 (HSP 70) were analysed by ELISA. The expressions of TNFα, IL1β, GFAP, nNOS, iNOS, HO-1, NFκB, Bax, Bad, AIF, Bcl2 and SIRT1 genes were detected by real-time (RT)-PCR. Western blots were used to measure the protein expression of NFκB p65, NFκB p50/105, IκBα, IκBβ, p38 MAPK, MAP-2 and synapsin I. We have assessed the ability of 17β-oestradiol and melatonin administration to downregulate markers of neuroinflammation in the dentate gyrus of ovariectomized female rats. Results indicated that 17β-oestradiol and melatonin treatments were able to significantly decrease expression of pro-inflammatory cytokines, iNOS and HO-1 in the hippocampus when compared to non-treated animals. A similar age-and long-term ovarian hormone depletion-related increase in GFAP was also attenuated after both melatonin and oestradiol treatments. In a similar way to oestradiol, melatonin decreased the activation of p38 MAPK and NFκB pathways. The treatments enhanced the levels of synaptic molecules synapsin I and MAP-2 and have been shown to modulate the pro-antiapoptotic ratio favouring the second and to increase SIRT1 expression. These findings support the potential therapeutic role of melatonin and oestradiol as protective antiinflammatory agents for the central nervous system during menopause.

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17-β estradiol in the acetylcholinesterase activity and lipid peroxidation in the brain and blood of ovariectomized adult and middle-aged rats

Abstract: 17-β estradiol is able to modulate the AChE activity and non-neuronal cholinergic response as well as to reduce lipid peroxidation. Its response is dependent on the age and brain structure analyzed.

Cited by 20 publications

References 62 publications

Differential role of estrogen receptor modulators in depression-like behavior and memory impairment in rats with postmenopausal diabetes

Differential role of estrogen receptor modulators in depression-like behavior and memory impairment in rats with postmenopausal diabetes

Effects of puerarin on cholinergic enzymes in the brain of ovariectomized guinea pigs

Melatonin and oestrogen treatments were able to improve neuroinflammation and apoptotic processes in dentate gyrus of old ovariectomized female rats

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