17 beta-Estradiol Induced Prostatitis in the Rat is an Autoimmune Disease

Seethalakshmi, L.; Bala, Rupa; Malhotra, Ravinder; Austin-Ritchie, T.; Miller-Graziano, Carol L.; Menon, Mani; Luber-Narod, Judith

doi:10.1016/s0022-5347(01)65548-4

Cited by 40 publications

(23 citation statements)

References 14 publications

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“…Models evaluating spontaneous, age-and genetically dependent prostatitis [7,8], and bacterial prostatitis [5] were followed by models demonstrating the autoimmune characteristics of the inflammation [9,10]. The model described in this paper examined the pathogenesis of inflammation from a mucosal surface perspective.…”

Section: Discussionmentioning

confidence: 99%

Rat model of experimentally induced abacterial prostatitis

et al. 2000

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Section: Discussionmentioning

confidence: 99%

Rat model of experimentally induced abacterial prostatitis

et al. 2000

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“…133 Currently, there is only one report that supports the autoimmune nature of sex-hormone-induced prostatitis. 134 Although these investigators used an unusually small number of in vitro activated splenocytes for the adoptive cell transfer, they reported that rat lobe-specific prostatitis can be induced in naive syngeneic recipients by adoptive transfer of spleen CD3 þ T cells from 17b-estradiol-treated male rat donors. It remains unclear whether this model of prostate inflammation is of autoimmune origin, since there is considerable evidence that 17b-estradiol is capable of inhibiting physical and histological signs of experimental autoimmune encephalomyelitis (EAE), a mouse model of human multiple sclerosis.…”

Section: Rat Models Of Prostatitismentioning

confidence: 99%

Experimental rodent models of prostatitis: limitations and potential

Vykhovanets

Resnick

MacLennan

et al. 2007

Prostate Cancer Prostatic Dis

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Prostatitis is a polyetiological inflammation of the prostate gland in men characterized by pelvic pain, irritative voiding symptoms, and sexual dysfunction. Histologically prostatitis is characterized by poly-and mononuclear cell infiltrates (neutrophils, lymphocytes, macrophages and plasma cells) in the stromal connective tissue around the acini or ducts. Prostatitis is an important worldwide health problem in men. The pathogenesis and diagnostic criteria for the condition are obscure, with the result that the development of management programs for this condition has been hindered. Animal model(s) might be useful in elucidating mechanisms involved in the molecular pathogenesis of chronic nonbacterial prostatitis and chronic pelvic pain syndrome. Given that prostatitis might have a multifactorial etiology, several animal models with unique features may prove helpful. This review examines a number of experimental rodent models of prostatitis and evaluates their advantages and limitations.

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“…The possibility of inducing prostatitis in laboratory animals by experimental manipulation of their immune system further supports this view. Thymectomy at birth [4], oestradiol administration which affects local antigen expression [5] or direct immunization with prostatic antigens in complete Freund's adjuvant (CFA) [6,7] result in typical histological infiltrates, similar to those seen in human patients [8].…”

Section: Introductionmentioning

confidence: 99%