“…Studies focused on differential susceptibility to the development of EAP have shown that NOD, C57BL/6, SJL, A⁄J, and BALB/c mice exhibited different severity of prostatic inflammation after EAP induction, with NOD and BALB/c mice the most susceptible and the most resistant strains, respectively (4,13,17). NOD mice develop severe inflammation in the prostate, accompanied by specific T cell-mediated responses that could be assessed by in vitro-specific proliferation and IFN-g production, but not IL-4 secretion (14,18). A crucial role of IFN-g in EAP has been shown because the absence of IFN-g or transcription factors involved in the IFN-g signaling cascade, such as IRF-1 and STAT-1, made mice resistant to EAP induction (14,19).…”