165 Evaluation of four prognostic scores in patients with acute-on-chronic liver failure

Hepatic and systemic hemodynamic derangements predict early mortality and recovery in patients with acute‐on‐chronic liver failure

“…Six ACLF patients witnessed an upper GI bleed during the study period. The median HVPG in the bleeders (n = 6, 16.8 [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] mmHg) was not different than that seen in the non-bleeders (n = 18, 15.8 [12-23.5] mmHg) (P = ns). However, in these six patients, the median grade of varices progressed from baseline 1 (0-2) to 2 (2-3) after follow-up of 3 months (P > 0.05).…”

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“…ACLF has been shown to carry poor prognosis, with an in-hospital mortality ranging from 50% to 66% [2,3]. Several extracorporeal liver support systems have been developed to improve prognosis in acute liver failure as well as ACLF, and in a recent meta-analysis, artificial liver support was shown to reduce mortality in ACLF as compared with standard medical treatment [4].…”

Enhanced Demethylation of Interferon-.GAMMA. Gene Promoter in Peripheral Blood Mononuclear Cells Is Associated with Acute-on-Chronic Hepatitis B Liver Failure

“…Hepatitis B virus (HBV)-related ACLF refers to liver failure occurring in patients with HBV related liver diseases including chronic hepatitis B (CHB), liver cirrhosis, or chronic asymptomatic hepatitis B surface antigen carriers (Chinese society of Infectious Diseases and Parasitology and Chinese Society of Hepatology of Chinese Medical Association 2000), which is termed as acute-onchronic hepatitis B liver failure (ACHBLF). ACHBLF has poor prognosis with an in-hospital mortality ranging from 50% to 66% (Sen et al 2004;Stauber et al 2006).…”