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Stadlbauer, Vanessa; Krisper, Peter; Aigner, Reingard; Haditsch, Bernd; Jung, Aleksandra; Lackner, Carolin; Stauber, Rudolf

doi:10.1186/cc5119

Cited by 122 publications

(24 citation statements)

References 39 publications

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“…Our results showed that L. fermentum I5007 supplementation or E. coli challenge had no effect on these cytokines in the serum. The fact that no differences were observed in cytokine levels in the serum may indicate that serum cytokines do not reflect a true picture of the rate of cytokine production/removal in piglets but are rather to be considered as a ''spillover'' from tissues (Stadlbauer et al 2006). Baken et al (2006) reported that Wistar WU rats orally administered with L. casei Shirota for eight consecutive days did not alter serum interferon-c, which is consistent with the present study.…”

Section: Discussionsupporting

confidence: 88%

Influence of Lactobacillus fermentum I5007 on the intestinal and systemic immune responses of healthy and E. coli challenged piglets

Aina

Gao

et al. 2009

Antonie van Leeuwenhoek

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The effect of feeding Lactobacillus fermentum I5007 on the immune system of weaned pigs with or without E. coli challenge was determined. Twenty-four weaned barrows (6.07 +/- 0.63 kg BW) were randomly assigned to one of four treatments (N = 6) in a factorial design experiment. The first two treatments consisted of healthy piglets with half of the pigs receiving no treatment while the other half was orally administered with L. fermentum I5007 (10(8) CFU/ml) at a daily dose of 20 ml. Pigs in the second two treatments were challenged on the first day with 20 ml of E. coli K88ac (10(8) CFU/ml). Half of these pigs were not treated while the remaining pigs were treated with 20 ml of L. fermentum I5007 (10(8) CFU/ml). Peripheral blood lymphocytes subsets were determined using flow cytometry. The intestinal mucosal immunity of the pigs was monitored by real time polymerase chain reaction. The cytokine content of the pig's serum was also analyzed. Oral administration of L. fermentum I5007 increased blood CD4(+) lymphocyte subset percentage as well as tumor necrosis factor-alpha and interferon-gamma expression in the ileum. Pigs challenged with E. coli had elevated jejunal tumor necrosis factor-alpha while interferon-gamma expression was increased throughout the small intestine. There was no difference in the concentration of the cytokines interleukin-2, interleukin-6, tumor necrosis factor-alpha and interferon-gamma in the serum. CD8(+) and CD4(+)/CD8(+) in peripheral blood were not affected by treatment. In conclusion, L. fermentum I5007 can enhance T cell differentiation and induce ileum cytokine expression suggesting that this probiotic strain could modulate immune function in piglets.

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Section: Discussionsupporting

confidence: 88%

Influence of Lactobacillus fermentum I5007 on the intestinal and systemic immune responses of healthy and E. coli challenged piglets

Aina

Gao

et al. 2009

Antonie van Leeuwenhoek

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“…However, a predilution mode was adopted in our system to reduce the blood concentration and clotting in the fraction plasma separator. With the aid of CVVH, the FPSA-CVVH system has the capability to remove water-soluble toxins, including proinflammatory cytokines and mediators, which have been reported to play a role in the evolution of ALF [23,24,25]. In addition, the FPSA-CVVH system was superior when the CVVH filter was placed in the plasma circuit because it avoided contact between the filter and blood, thus reducing the risk of clotting and the required dose of anticoagulant.…”

Section: Discussionmentioning

confidence: 99%

Efficient Removal of Serum Bilirubin by a Novel Artificial Liver Support System Using Albumin Convection: A Pilot Study

Gong¹,

Ji²,

Zhu³

et al. 2012

Blood Purif

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Background/Aims: To compare the efficacy of a new artificial liver support system, fractionated plasma separation and adsorption integrated with hemofiltration, with the old system, plasma adsorption. Methods: Sixteen patients with acute liver failure each received a first session of treatment using the old system, in which plasma was perfused through an adsorber. They then received a second session using the new system, in which albumin-rich plasma separated using a fraction plasma separator was ultrafiltrated using a hemofilter and perfused through an adsorber before being returned to blood. Results: The new system had a higher clearance of bilirubin and slower decline of clearance over time. There was a lower reduction ratio of bilirubin, bile acid, urea, and creatinine; longer prolongation of coagulation parameters; and greater decline in albumin level using the old system compared with the new one. Conclusions: Use of the novel system results in more efficient removal of toxins and fewer deterious effects than the old system.

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“…Acute-on-chronic hepatic failure (AOCHF) has been defined as an acute deterioration of liver function in chronic liver disease that ultimately leads to multi-organ failure within 4–6 weeks, with a mortality rate of 53% (2). Liver transplantation has long been recognized as the most effective therapy in the treatment of AHF and AOCHF (3).…”

Section: Introductionmentioning

confidence: 99%

Artificial and bioartificial liver support systems for acute and acute-on-chronic hepatic failure: A meta-analysis and meta-regression

Zheng

et al. 2013

Experimental and Therapeutic Medicine

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Artificial and bioartificial liver support systems (LSSs) appear to be safe and effective in the treatment of acute and acute-on-chronic hepatic failure (AHF and AOCHF); however, individually published studies and previous meta-analyses have revealed inconclusive results. The aim of the present meta-analysis was to derive a more precise estimation of the benefits and disadvantages of artificial and bioartificial LSSs for patients with AHF and AOCHF. A literature search was conducted in the PubMed, Embase, Web of Science and Chinese Biomedical (CBM) databases for publications prior to March 1, 2013. Crude relative risks (RRs) or standardized mean differences (SMDs) with 95% confidence intervals (95% CI) were calculated using either the fixed effects or random effects models. Nineteen randomized controlled trials (RCTs) were included, which comprised a total of 566 patients with AHF and 371 patients with AOCHF. The meta-analysis showed that artificial LSS therapy significantly reduced mortality in patients with AOCHF; however, it had no apparent effect on total mortality in patients with AHF. The results also indicated that the use of bioartificial LSSs was correlated with decreased mortality in patients with AHF. A significant reduction in the bridging to liver transplantation was observed in patients with AOCHF following artificial LSS therapy; however, similar results were not observed in patients with AHF. Patients with AHF and those with AOCHF showed significant reductions in total bilirubin levels following artificial LSS therapy. There were no significantly increased risks of hepatic encephalopathy or bleeding in either the patients with AHF or AOCHF following artificial or bioartificial LSS therapies. Univariate and multivariate meta-regression analyses confirmed that none of the factors explained the heterogeneity. The present meta-analysis indicated that artificial LSSs reduce mortality in patients with AOCHF, while the use of bioartificial LSSs was correlated with reduced mortality in patients with AHF.

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Untitled

Cited by 122 publications

References 39 publications

Influence of Lactobacillus fermentum I5007 on the intestinal and systemic immune responses of healthy and E. coli challenged piglets

Influence of Lactobacillus fermentum I5007 on the intestinal and systemic immune responses of healthy and E. coli challenged piglets

Efficient Removal of Serum Bilirubin by a Novel Artificial Liver Support System Using Albumin Convection: A Pilot Study

Artificial and bioartificial liver support systems for acute and acute-on-chronic hepatic failure: A meta-analysis and meta-regression

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