152. Acyl migration in diglycerides

Crossley, Arthur William; Freeman, I. P.; Hudson, B. J. F.; Pierce, Jana

doi:10.1039/jr9590000760

Cited by 78 publications

(20 citation statements)

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“…Although the isoform of DAG that occurs in the process of triacylglycerol (TAG) digestion by lingual or pancreatic lipase is 1,2-or 2,3-DAG, a substantial fraction of DAG in edible oils has been converted to 1,3-DAG by acyl migration (4). We previously reported that the rate of lymphatic transport of TAG as chylomicron was significantly retarded in rats that had been intragastrically infused with DAG oil emulsion as compared to TAG oil emulsion (5).…”

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confidence: 99%

Energy value and digestibility of dietary oil containing mainly 1,3‐diacylglycerol are similar to those of triacylglycerol

Taguchi

Nagao

Watanabe

et al. 2001

Lipids

127

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Diacylglycerol (DAG) is a component of various vegetable oils. Approximately 70% of the DAG in edible oils are in the configuration of 1,3-DAG. We recently showed that long-term ingestion of dietary oil containing mainly 1,3-DAG reduces body fat accumulation in humans as compared to triacylglycerol (TAG) oil with a similar fatty acid composition. As the first step to elucidate the mechanism for this result, we examined the difference in the bioavailabilities of both oils by measuring food energy values and digestibilities in rats. Energy values of the DAG oil and the TAG oil, measured by bomb calorimeter, were 38.9 and 39.6 kJ/g, respectively. Apparent digestibility expressed according to the formula: (absorbed) x (ingested)(-1) x 100 = (ingested - excreted in feces) x (ingested)(-1) x 100 for the DAG oil and the TAG oil were 96.3+/-0.4 and 96.3+/-0.3% (mean +/- SEM), respectively. The similarity in the bioavailabilities of both oils supports the hypothesis that the reduced fat accumulation by dietary DAG is caused by the different metabolic fates after the absorption into the gastrointestinal epithelial cells.

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confidence: 99%

Energy value and digestibility of dietary oil containing mainly 1,3‐diacylglycerol are similar to those of triacylglycerol

Taguchi

Nagao

Watanabe

et al. 2001

Lipids

127

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“…Natural edible oil contains 1,2-DG and 1,3-DG as minor components. 1,2-DG is converted to 1,3-DG by acyl migration in edible oils (10). 1,2-DG is an intermediate of triacylglycerol diges tion in the intestine.…”

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Comparisons of Glucose and Lipid Metabolism in Rats Fed Diacylglycerol and Triacylglycerol Oils

Sugimoto

Kimura

Fukuda

et al. 2003

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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SummaryThe effects of dietary 1,3-diacylglycerol-rich oil (DG oil) on biochemical find ings related to glucose and lipid metabolisms were investigated in comparison with triacyl glycerol oil (TG oil) in normal rats. Young (7wk-old) and old (8mo-old) rats were fed a syn thetic diet containing 10% (by weight) DG or TG oil for 1, 4, 8, or 12wk. The body weights, epididymal and perirenal adipose tissue weights, and feed efficiency were not significantly different in the dietary oil groups during any feeding period. The plasma and liver triacyl glycerol concentrations were not different in the dietary groups, except that the plasma tria cylglycerol concentrations were rather lower only in the portal vein of rats fed DG oil. The plasma glucose and free fatty acid concentrations were significantly higher in rats fed DG oil as compared to TG oil. In the old rats fed DG oil for 8wk, the fasted plasma glucose and in sulin concentrations were elevated and glucose intolerance was observed. The insulin re ceptor expression was not different due to dietary oil, but was markedly reduced with aging. Thus, the anti-obesity and lipid-lowering effects of dietary DG oil were not found. Moreover, it appeared that the glucose intolerance might be induced by dietary DG oil, particularly in the old rats.

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“…Natural edible oil contains 1, 2 DG and 1, 3-DG as minor components. 1, 2-DG is con verted to 1, 3-DG by aryl migration in edible oils (10). 1, 2-DG is an intermediate of TG digestion in the intes tine.…”

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confidence: 99%

Dietary Diacyiglycerol-Rich Oil Stimulation of Glucose Intolerance in Genetically Obese Rats

Sugimoto

Fukuda

Kimura

et al. 2003

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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SummaryThe effects of dietary 1, 3-diacylglycerol-rich oil (DG oil) on glucose and lipid metabolism were investigated in comparison with triacylglycerol (TG) oil in female geneti cally obese Wistar fatty rats. The obese rats and their lean littermates (8wk old) were fed a synthetic diet containing 10% (w/w) DG or TG oil for 5 wk. The body weights, abdominal fat weights, and the plasma and liver TG concentrations were not significantly different due to dietary fat type in the obese and lean rats. The plasma glucose concentrations were sig nificantly elevated by dietary DG oil as compared to TG oil in the portal vein and inferior vena cava of obese and lean rats. The plasma free fatty acid concentrations were markedly elevated by dietary DG oil as compared to TG oil in the portal vein and inferior vena cava of both genotype rats, particularly in the obese rats. In the glucose tolerance test, the obese rats fed DG oil showed glucose intolerance, possibly due to the markedly elevated plasma free fatty acids. Thus, the effects of dietary DG oil on lipid-lowering effects and anti-obesity were not observed in either genotype in the present study. Moreover, it is remarkable that glucose intolerance was induced by dietary DG oil in the genetically obese rats.

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152. Acyl migration in diglycerides

Cited by 78 publications

References 0 publications

Energy value and digestibility of dietary oil containing mainly 1,3‐diacylglycerol are similar to those of triacylglycerol

Energy value and digestibility of dietary oil containing mainly 1,3‐diacylglycerol are similar to those of triacylglycerol

Comparisons of Glucose and Lipid Metabolism in Rats Fed Diacylglycerol and Triacylglycerol Oils

Dietary Diacyiglycerol-Rich Oil Stimulation of Glucose Intolerance in Genetically Obese Rats

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