15-year experience with rotavirus vaccination in Mexico: a systematic literature review

Guzmán-Holst, Adriana; Ortega-Barrı́a, Eduardo; Flores, Ángel Alexis; Carreño-Manjarrez, Roberto; Constenla, Dagna; Cervantes-Apolinar, María Yolanda

doi:10.1080/21645515.2021.1936859

Cited by 3 publications

(1 citation statement)

References 48 publications

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“…The most prevalent sequences belonged to the Reoviridae and Caliciviridae families, which are the most common agents associated with diarrhoea among children. Epidemiological studies of Rotavirus illness worldwide, have revealed a similar prevalence in children from industrialized and less developed regions of the world, including Mexico, and it seems that Norovirus (Caliciviridae) illness has a similar prevalence in children from these regions, as well [41][42][43][44][45]. Other sequences that were found among our children included Mamastrovirus 1, which has been associated with approximately 5% of diarrheal episodes in Spanish children < 5 years old [46], while Astrovirus MLB1 was identified in 6% of Kenyan children with diarrhoea [46,48].…”

Section: Discussionmentioning

confidence: 99%

Differential virome composition and richness between children's diarrheagenic stools kept at ultra-low temperatures for long-term

Becerra

Iša

Gutiérrez-Escolano

et al. 2023

J Infect Dev Ctries

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Introduction: Diarrhoeal illness is the second cause of morbidity/mortality among children from less-developed regions worldwide. Nonetheless, there is scarce information regarding their gut microbiome. Aim: Microbiome characterization, with an emphasis on the virome, of children’s stools with diarrhoea, by a commercial microbiome array. Methodology: Nucleic acids extraction, optimised for viral identification, of stool samples from 20 Mexican children with diarrhoea (10 children < 2 and 10 ≥ 2-years-old), collected 16 years ago and kept at -70 °C, were analysed for the presence of viruses, bacteria, archaea, protozoa, and fungi species sequences. Results: Only viral and bacterial species sequences were identified among children’s stools. Most stool samples harboured species belonging to the bacteriophages (95%), anellovirus (60%), diarrhoeagenic viruses (40%), and non-human pathogens viruses (45% avian virus and 40% plant viruses) groups. Among the children's stools, virome inter-individual species composition was observed, even in presence of illness. The < 2-years-old children group has significantly higher viral richness (p = 0.01), conferred mainly by bacteriophages and diarrheagenic-viruses (p = 0.01) species, in comparison with the ≥ 2-years-old group. Conclusions: The virome of stools of children with diarrhoea revealed inter-individual viral species composition. Similarly, to the few virome studies in healthy young children, the bacteriophages group was the most abundant. A significantly higher viral richness, conferred by bacteriophages and diarrheagenic-viral species, was observed among < 2-years-old children in comparison with older children. Stools preserved at -70 °C for long term can successfully be used for microbiome studies.

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Section: Discussionmentioning

confidence: 99%

Differential virome composition and richness between children's diarrheagenic stools kept at ultra-low temperatures for long-term

Becerra

Iša

Gutiérrez-Escolano

et al. 2023

J Infect Dev Ctries

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The Importance of Vaccines in a Sustainable Healthy Society

Gül

Alak

Gül

et al. 2023

A Sustainable Green Future

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Immunogenicity of RV1 and RV5 vaccines administered in standard and interchangeable mixed schedules: a randomized, double-blind, non-inferiority clinical trial in Mexican infants

Macías-Parra,

Vidal-Vázquez,

Reyna-Figueroa

et al. 2024

Front. Public Health

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IntroductionRotavirus-associated diarrheal diseases significantly burden healthcare systems, particularly affecting infants under five years. Both Rotarix™ (RV1) and RotaTeq™ (RV5) vaccines have been effective but have distinct application schedules and limited interchangeability data. This study aims to provide evidence on the immunogenicity, reactogenicity, and safety of mixed RV1-RV5 schedules compared to their standard counterparts.MethodsThis randomized, double-blind study evaluated the non-inferiority in terms of immunogenicity of mixed rotavirus vaccine schedules compared to standard RV1 and RV5 schedules in a cohort of 1,498 healthy infants aged 6 to 10 weeks. Participants were randomly assigned to one of seven groups receiving various combinations of RV1, and RV5. Standard RV1 and RV5 schedules served as controls of immunogenicity, reactogenicity, and safety analysis. IgA antibody levels were measured from blood samples collected before the first dose and one month after the third dose. Non-inferiority was concluded if the reduction in seroresponse rate in the mixed schemes, compared to the standard highest responding scheme, did not exceed the non-inferiority margin of −0.10. Reactogenicity traits and adverse events were monitored for 30 days after each vaccination and analyzed on the entire cohort.ResultsOut of the initial cohort, 1,365 infants completed the study. Immunogenicity analysis included 1,014 infants, considering IgA antibody titers ≥20 U/mL as seropositive. Mixed vaccine schedules demonstrated non-inferiority to standard schedules, with no significant differences in immunogenic response. Safety profiles were comparable across all groups, with no increased incidence of serious adverse events or intussusception.ConclusionThe study confirms that mixed rotavirus vaccine schedules are non-inferior to standard RV1 and RV5 regimens in terms of immunogenicity and safety. This finding supports the flexibility of rotavirus vaccination strategies, particularly in contexts of vaccine shortage or logistic constraints. These results contribute to the global effort to optimize rotavirus vaccination programs for broader and more effective pediatric coverage.Clinical trial registration: ClinicalTrials.gov, NCT02193061.

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15-year experience with rotavirus vaccination in Mexico: a systematic literature review

Cited by 3 publications

References 48 publications

Differential virome composition and richness between children's diarrheagenic stools kept at ultra-low temperatures for long-term

Differential virome composition and richness between children's diarrheagenic stools kept at ultra-low temperatures for long-term

The Importance of Vaccines in a Sustainable Healthy Society

Immunogenicity of RV1 and RV5 vaccines administered in standard and interchangeable mixed schedules: a randomized, double-blind, non-inferiority clinical trial in Mexican infants

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