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Craciun, V.; Calugaru, Ghiorghe; Badescu, V.

doi:10.1023/a:1015590930284

Cited by 11 publications

(3 citation statements)

References 5 publications

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“…In this work, the numerical model was developed based on finite differencing scheme and it showed a good agreement with the derived analytical solution. Craciun and Calugaru also explored the use of FDM in describing the heat transfer in MFH [143]. They created the algorithm for solving the heat transfer equation by incorporating the tissue metabolism heat term and the heat sink due to the blood vessel.…”

Section: Numerical Modelingmentioning

confidence: 99%

Physical mechanism and modeling of heat generation and transfer in magnetic fluid hyperthermia through Néelian and Brownian relaxation: a review

2017

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Current clinically accepted technologies for cancer treatment still have limitations which lead to the exploration of new therapeutic methods. Since the past few decades, the hyperthermia treatment has attracted the attention of investigators owing to its strong biological rationales in applying hyperthermia as a cancer treatment modality. Advancement of nanotechnology offers a potential new heating method for hyperthermia by using nanoparticles which is termed as magnetic fluid hyperthermia (MFH). In MFH, superparamagnetic nanoparticles dissipate heat through Néelian and Brownian relaxation in the presence of an alternating magnetic field. The heating power of these particles is dependent on particle properties and treatment settings. A number of pre-clinical and clinical trials were performed to test the feasibility of this novel treatment modality. There are still issues yet to be solved for the successful transition of this technology from bench to bedside. These issues include the planning, execution, monitoring and optimization of treatment. The modeling and simulation play crucial roles in solving some of these issues. Thus, this review paper provides a basic understanding of the fundamental and rationales of hyperthermia and recent development in the modeling and simulation applied to depict the heat generation and transfer phenomena in the MFH.

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Section: Numerical Modelingmentioning

confidence: 99%

Physical mechanism and modeling of heat generation and transfer in magnetic fluid hyperthermia through Néelian and Brownian relaxation: a review

2017

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“…The above-indicated mechanisms dominate in cooling of the tissue and change very considerably during heating. A number of authors analyzed the problem of heat transfer when a certain volume of the tissue was heated from inside by uniformly distributed heat sources -microscopic magnetic particles [57][58][59]. The problem of temperature decrease due to blood circulation was not considered at all owing to its mathematical complexity and the lack of general results.…”

Section: Application Of Magnetic Hyperthermia In Oncologymentioning

confidence: 99%

Magnetic induction hyperthermia

Никифоров

2007

Russ Phys J

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A review of physical principles and experimental data on magnetic hyperthermia are presented. The main principles of magnetic hyperthermia are considered. Results of its application in the therapy of oncology diseases are presented. PHYSICAL PRINCIPLES OF HYPERTHERMIATwo components of ac electromagnetic fields E and H can cause heating of tissues. Based on the Maxwell equations and thermodynamic relations, not only the electrocaloric effect, namely, the heat absorption in substance caused by the electric field component E [6], but also the magnetocaloric effect caused by variations in H can be calculated. These effects are mainly determined by the dielectric (ε and δε/δТ) and magnetic (μ) properties of substances, respectively. Because magnetism of biological objects is negligibly small, biologically compatible nontoxic magnetic nanoparticles (based on magnetite and so on) are used to strengthen the influence of an external magnetic field.Thermodynamic relations for a magnet in a magnetic field are similar to those for a dielectric in an electric field [6]. However, an essential difference is that the magnetic field, unlike the electric field, does no work on charges moving in it, because the Lorentz force is perpendicular to the velocity vector of the moving charge. To calculate a change in the energy of the medium when the magnetic field is switched on, electric fields induced by magnetic field variations should be considered. In their turn, high-frequency electromagnetic fields cause heating due to the electric field component. At low frequencies, this effect is insignificant. At the same time, the role of the magnetic field component in magnet heating is significant only at low frequencies [6]. Therefore, inclusion of electromagnetic induction hyperthermia in a separate class of high-frequency phenomena [1], on the one hand, and of magnetic hyperthermia as a low-frequency influence, on the other hand, though relative, is justified.Low-frequency (less than 100 kHz) electromagnetic fields can cause heating of magnetic nanoparticles at the expense of the magnetocaloric effect [7], magnetic reversal in the presence of a hysteresis loop, and magnetic crystal anisotropy of superparamagnetic particles. Physics of the magnetocaloric effect of this phenomenon is the following: elementary magnetic moments are directed chaotically without magnetic field, and hence the magnetic contribution to the entropy is significant. As the magnetic field increases, the magnetic moments are ordered along the field. As a result, the magnetic entropy component S M decreases. Because the magnetization process is close to adiabatic one, the total entropy S does not change, but the entropy component caused by thermal motion increases. Thus, the ferromagnet temperature increases with the magnetic field. Quantitatively, the temperature change is calculated from the formula From the above formula it follows that the temperature can raise when the magnetic moment М S changes with temperature, since the heat capacity C is always positive. The ...

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“…At the same time there should be retention of ambient magnetic property so that they can be used for switching applications [10] For targeted drug delivery the external magnetic field gradients can be used to direct the functionalized magnetic particles to the specific site, retain and subsequently remove them. The in vivo route inherently has certain limitations which can be overcome by modifications in techniques and materials used in the process [11][12][13][14][15]. The coated magnetic nano particles are required to exhibit magnetic properties, remain stable, well dispersed and not aggregate to inhibit the blood flow.…”

Section: Introductionmentioning

confidence: 99%

Functionalization of Cobalt Ferrite Nanoparticles with Alginate Coating for Biocompatible Applications

Tamhankar¹,

Kulkarni²,

Watawe³

2011

MSA

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The soft magnetic materials have potential applications in the field of bioengineering as carriers for targeted drug delivery. The magnetic properties, particle size after coating, Curie temperature and its biocompatibility are important parameters for the synthesis of materials. In the present communication cobalt ferrite nanoparticles have been synthesized using co-precipitation method and coated with sodium alginate. The X-ray diffraction and infrared spectroscopic measurements have been used to confirm the ferrite structure formation and coating of the samples with alginate. The SEM micrographs have been used to confirm the particle size which is found to be 45 nm before coating and 78 nm after coating. The saturation magnetization obtained using the hysteresis data for the uncoated cobalt ferrite sample is 19.8 emu/gm while for the coated sample it reduces to 10.2 emu/gm. The AC susceptibility measurements indicate SP structure for the uncoated samples with Curie temperature less than 100℃. The thermo gravimetric measurements have been used to estimate the amount of alginate coating on the sample and it has been correlated with retention of magnetic properties after coating. The value of saturation magnetization reduces after coating due to mass reduction of magnetic material in the sample in accordance with the TGA measurements

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Untitled

Cited by 11 publications

References 5 publications

Physical mechanism and modeling of heat generation and transfer in magnetic fluid hyperthermia through Néelian and Brownian relaxation: a review

Physical mechanism and modeling of heat generation and transfer in magnetic fluid hyperthermia through Néelian and Brownian relaxation: a review

Magnetic induction hyperthermia

Functionalization of Cobalt Ferrite Nanoparticles with Alginate Coating for Biocompatible Applications

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