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Нагоев, Б. С.; Абидов, М. Т.; Ivanova, Maria

doi:10.1023/a:1022909127992

Cited by 10 publications

(2 citation statements)

References 5 publications

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“…Moreover, in a study on patients with HBV-associated HCC, significant elevation of superoxide anion radicals was observed (29). This increase in superoxide anions was also seen in the leukocytes of patients with CVHB (75). Although this parameter is difficult to measure, further studies in this field could reveal correlations between ROS/RNS production and hepatitis B disease activity.…”

Section: Resultsmentioning

confidence: 63%

Hepatitis B and its Relationship With Oxidative Stress

Alavian

Showraki

2016

Hepat Mon

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ContextDespite the great breakthroughs we have witnessed in the last 50 years in the prevention, diagnosis, and treatment of hepatitis B, we are still far from eradicating or even curing the disease. Achieving further progress in controlling this disease will not be possible without discovering the exact pathogenesis behind it. One prime suspect in the pathogenesis of various diseases is oxidative stress. This review will exclusively explore hepatitis B in the context of oxidative stress to obtain a more comprehensive clinical perspective on its pathogenesis and eventual medical therapy.Evidence AcquisitionWe systematically searched PubMed, Google Scholar, Web of Science, EMBASE, and Scopus using an extensive list of keywords in the following three categories: 1) Hepatitis B and oxidation 2) Hepatitis B and antioxidant system 3) Effects of approved anti-hepatitis B drugs on redox status. All relevant articles were obtained and reviewed carefully after the exclusion criteria were deployed.ResultsThere is great evidence indicating extensive oxidative stress occurs in hepatitis B. This oxidative stress takes place on multiple levels, including lipid peroxidation, DNA oxidation, protein oxidation, and reactive oxygen and nitrogen species production. However, there are also conflicting results with regard to antioxidant therapy and antioxidant status in hepatitis B, some of which may be explained by the concept of “compensatory gaps.” Nevertheless, further studies are indicated to reach a more thorough judgment.ConclusionsDespite the presence of vast oxidative stress in hepatitis B, antioxidant therapy is not always effective as a treatment strategy, especially considering that antioxidants can act as “double-edged swords” or antioxidants; if not used at the right time or place or in the right combination, these substances can easily become pro-oxidants. Therefore, several studies will be needed to determine suitable antioxidant therapies. We propose the “2-step Combined Antioxidant Adjuvant Therapy for hepatitis B (2CAAT Hep B)” as a new strategy for antioxidant adjuvant therapy. We also suggest developing an international platform and database for antioxidant adjuvant therapy in hepatitis B (IPAATH and IDAATH) to canalize this field of research in a standardized direction, especially when complexity is a problem.

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Section: Resultsmentioning

confidence: 63%

Hepatitis B and its Relationship With Oxidative Stress

Alavian

Showraki

2016

Hepat Mon

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“…There are some studies in the literature that investigated MDA in plasma, serum and erythrocytes of patients with hepatitis. It was demonstrated that serum MDA level was increased in patients with HCV during regression and early convalescence [19]. In liver damage caused by viral etiology, it is reported that the MDA level increases in serum and liver tissue.…”

Section: Discussionmentioning

confidence: 99%

Biochemical assessment of oxidative stress in hepatitis C virus infected patients : A comparison of different groups

2017

AJBPR

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The present study aimed to evaluate the serum levels of malodialdehyde (MDA) as a marker for oxidative stress in different groups of HCV infected patients, to elucidate the potential role of oxidative stress in disease progression and possibly the occurrence of hepatocarcinogenesis among such patients. The present study has been conducted on 82 HCV infected patients recruited from the Department of Tropical Medicine and Gastroenterology of Assuit University Hospitals. The patients were classified into three subgroups: those have chronic hepatitis (chronic HCV) and include 24 patients, those have cirrhosis (cirrhosis HCV) and include 32 patients and the last subgroup includes 26 patients with hepatocelluar carcinoma (malignancy HCV). This was in addition to 23 healthy age and sex matched subjects selected as controls. Serum levels of MDA were measured in the included subjects by chemical method using spectrophotometer. The findings of the present study revealed that the mean of MDA in chronic and malignant HCV patients were significantly higher than its levels in the healthy group (p< 0.05), while in cirrhotic HCV cases were insignificantly higher than the healthy volunteers(p˃ 0.05). This confirms the presence of oxidative stress among HCV infected patients especially in chronic and malignant HCV patients which could be a cofactor in the process of HCV induced hepatocarcinogenesis.

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