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Abstract

Use policyThe full-text may be used and/or reproduced, and given to third parties in any format or medium, without prior permission or charge, for personal research or study, educational, or not-for-pro t purposes provided that:• a full bibliographic reference is made to the original source • a link is made to the metadata record in DRO • the full-text is not changed in any way The full-text must not be sold in any format or medium without the formal permission of the copyright holders.Please consult the full DRO policy for further details. The accurate and detailed characterization of arti®cial joint wear debris is important in determining both the wear rate of prostheses and understanding the role that the debris plays in the development and progression of aseptic loosening. The novel application of low angle laser light scattering (LALLS) to the particle size characterization of ultra high molecular weight polyethylene (UHMWPE) wear debris is described. The results demonstrate that both ex vivo and in vitro origin wear debris samples, at concentrations typical of those produced via an alkali-digestion retrieval route, can be reproducibly analyzed via LALLS. Because the LALLS route enables particle size analysis of the entire debris sample to be acquired non-destructively and whilst in suspension, artefacts associated with ®ltering, drying and agglomeration of debris are avoided, in contrast to currently used techniques such as ®ltration and scanning electron microscopy (SEM) observation.

Wear Debris Characterization and Corresponding Biological Response: Artificial Hip and Knee Joints

“…Polyethylene, metal, and ceramics particles have different individual isolation protocols, as shown in Table 1. Nevertheless the reported common steps of particle isolation protocol are categorized into three different stages [87–105]: (Step 1) sample delipidation and tissue digestion; (Step 2) dilution, centrifugation, and protein separation and (Step 3) ultrasonication and debris separation. These steps are summarized from a regular chain of a continuous isolation process and are illustrated as a flowchart (Figure 2).…”

“…The results showed good correlation with the radiographic appearance and indicated that extended tissue damage in a particular zone around the total joint that was proportional to the volume of the wear debris in that zone. Another extraction method of analysis is laser diffraction particle analysis [87], which has advantages in retaining the particles in the solution produced by the purification technique that avoids agglomeration and contamination [123]. Three-dimensional imaging approaches for particle quantification were reported in several studies [34,109,125,126].…”

A Quantitative Model of Wear Loss Based on On-Line Visual Ferrograph

“…The wear particles in the lubricant are satisfied some inherent distribution [6][7][8][9][10][11]. And wear debris size distribution usually meets the two parameters Weibull distribution function [9][10][11].…”