142P Correlation between histological pattern and hotspots EGFR mutations in Moroccan lung adenocarcinoma

Abstract

higher TMB (median, 29.9 vs 2.99; p<0.0001). Furthermore, previous studies have shown that copy-number alteration correlates with worse survival in immunotherapy, which means that FGA is a poor prognostic biomarker of immunotherapy. Gastric cancers with KMT2C/D exhibited significantly lower FGA than those without KMT2C/D mutations (median FGA: 0.085 with KMT2C/D vs 0.20805 without, p<0.0001).Conclusions: These results show that KMT2C/D mutations may be associated with higher TMB, MSI and lower FGA in gastric cancer. KMT2C/D genes might serve as promising prognostic factors for its immunotherapy.Legal entity responsible for the study: The authors.