135 The French national mesothelioma surveillance program

Goldberg, Marcel; Imbernon, Ellen; Rolland, Patrick; Ilg, Annabelle Gilg Soit; Quillacq, A. de; Frenay, C.; Chamming’s, Soizick; Launoy, Guy; Pairon, Jean‐Claude; Astoul, Philippe; Galateau-Sallé, F.; Brochard, Patrick

doi:10.1016/s0169-5002(07)70211-8

Cited by 8 publications

(2 citation statements)

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“…Asbestos exposure was evident to be the major cause for this cancer by 90% (8). while 70-80% of the cases related to occupational exposure (9). Consequently, patients are diagnosed at a very late stage of the disease (10).…”

Section: Introductionmentioning

confidence: 99%

LncRNAs Gas5, MALAT1 and SNHG8 as Predictive Diagnostic Biomarkers for Epithelioid Malignant Pleural Mesothelioma in the Egyptian Patients

Kiriacos,

Elkahwagy,

Sobeih

et al. 2023

Preprint

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Background Long non coding RNAs have proved their involvement in myriad of pathways whether physiological or pathological. To date, malignant pleural mesothelioma, MPM, is considered extremely aggressive cancer. One reason for this is the late diagnosis of the disease which could range from 30–40 years from asbestos exposure. There is an immense need for the development of new, sensitive, cheap and easy way for the early detection of the disease other than invasive ways as biopsies. The aim of this study is determination of expression of circulating lncRNAs in mesothelioma patients’ plasma searching for potential biomarkers. Methodology: Ten of previously identified lncRNA that were shown to have aberrant expression in mesothelioma tissues were selected as candidates for subsequent validation. The ten selected candidate LncRNA were verified using quantitative PCR (qPCR) in human plasma samples from mesothelioma patients versus healthy controls. Results Expression of circulating GAS5, SNHG8 and MALAT1 were significantly increased in plasma samples of patients when compared to controls. The ROC analysis of both MALAT1 and SNHG8 was; 88.89% sensitivity and 66.67% specificity. Their sensitivity was higher than that of GAS5 (sensitivity 72.22% and specificity 66.67%). The prediction model of GAS5 was statistically significant while that of SNHG8 and MALAT1 was not-probably due to small sample size. The AUC of the three ROC curves were acceptable and significant; 0.7519 for GAS5, 0.7352 for SNHG8 and 0.7185 for MALAT1. Which confirms their discrimination ability as markers. The three lncRNAs were not affected by age, gender or smoking status. Conclusion The three lncRNAs showed great potential as predictive diagnostic biomarkers independently. Although the prediction model for MALAT1 did not show significance, it was significantly expressed in patients more than controls p = 0.0266 and recorded sensitivity and specificity levels higher than those of GAS5.

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Section: Introductionmentioning

confidence: 99%

LncRNAs Gas5, MALAT1 and SNHG8 as Predictive Diagnostic Biomarkers for Epithelioid Malignant Pleural Mesothelioma in the Egyptian Patients

Kiriacos,

Elkahwagy,

Sobeih

et al. 2023

Preprint

View full text Add to dashboard Cite

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“…In 2016, India and China were the world's leading asbestos consumers (308.000/288.000 tonnes, respectively) and, in 2018, Russia represented the largest producer of asbestos used worldwide (710.000 tonnes) [16]. For this reason, it is also estimated that diseases related to this exposure, notably MPM, will continue to be a major health problem for many decades to come, increasing 5-10% per year, in industrialized countries, in a heterogeneous manner [8,15,18].…”

Section: Introductionmentioning

confidence: 99%

Asbestos Exposure and Malignant Pleural Mesothelioma: A Systematic Review of Literature

Santos

Dixe

Sacadura‐Leite

et al. 2022

Port J Public Health

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Background:The relationship between exposure to asbestos and malignant pleural mesothelioma (MPM) is already well established. Nevertheless, much remains to be known about exposure thereto and the incidence and mortality from MPM. Objective: This systematic review aims to map the relationship between asbestos and MPM by studying the exposure to asbestos and the incidence and mortality of MPM. Methods: A systematic review was conducted relating asbestos and MPM. Exposure to asbestos, incidence, and mortality by MPM was reviewed. PubMed, Web of Science, Cochrane Library, RCAAP, DART-Europe, and the reference lists of included studies were searched, from January 1, 1960, to December 31, 2020. Methodological quality was checked, the risk of bias analysis was performed, a level of evidence grade was assigned, and descriptive data analysis was performed. Results: 3,484 unique citations were identified, which included seventeen observational studies that met inclusion criteria with a total of 1,104 patients. Heterogeneity is present between the included studies which range from a case series of 16 retrospective studies and 1 prospective study. Studies were mostly conducted in Europe, particularly in Italy (6), and were published between 1969 and 2020. The mean age of patients is approximately 66 years with a latency period between the first exposure and diagnosis of approximately 42 years. 14 studies present data regarding the occupational context and chrysotile and crocidolite are the most studied types of fibre. The incidence of cases occurred between the interval 1966 and 2014 and in 9 studies the mortality rate was 100% of patients. Conclusion: There is high evidence to support the relationships between asbestos and MPM. However, the relatively scant information provided by the studies reinforces the need for well-conducted research and implementation of National Mesothelioma Surveillance Centres at a global level.

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Cancer mortality in a surveillance cohort of German males formerly exposed to asbestos

Pesch

Taeger

Johnen

et al. 2010

International Journal of Hygiene and Environmental Health

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135 The French national mesothelioma surveillance program

Cited by 8 publications

References 0 publications

LncRNAs Gas5, MALAT1 and SNHG8 as Predictive Diagnostic Biomarkers for Epithelioid Malignant Pleural Mesothelioma in the Egyptian Patients

LncRNAs Gas5, MALAT1 and SNHG8 as Predictive Diagnostic Biomarkers for Epithelioid Malignant Pleural Mesothelioma in the Egyptian Patients

Asbestos Exposure and Malignant Pleural Mesothelioma: A Systematic Review of Literature

Cancer mortality in a surveillance cohort of German males formerly exposed to asbestos

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