1288 Dermatosis papulosa nigra: A quality of life survey study

Abstract

Stem cell factor (SCF) is developmentally critical for melanocyte migration, differentiation, and survival. Recently, SCF expression in hair shaft progenitor cells has been shown to be absolutely required for the pigmentation in hair shafts, as evidenced by the complete loss of hair pigmentation in mice without SCF in these epithelial cells. Interestingly, this fully disruption of hair pigmentation only targets melanogenic mature monocytes in the upper hair bulb, but not melanocyte precursors below. This shows an important role of SCF in the determination of mature melanocytes to their destination. Here we report that the skin pigmentation in the dermis layer appears to follow the same mechanism for the distribution of dermal melanocytes. We employed multiple cell-type specific Scf knockout mice to characterize the sources and contribution of SCF to dermal pigmentation. Our results show that dermal melanocytes are also sustained by SCF. However, in contrast to hair pigmentation, dermal pigmentation appears to be supported by SCF expression in a selective population of dermal cells. This study reveals a faithful distribution of melanogenic melanocytes in distinct skin compartments guided by selective populations of SCF expressing cells. Our findings suggest that manipulation of SCF expression in the skin cells might be a potential target to manage hyper-or hypo-pigmented skin manifestations in clinic.

Facial dermatosis papulosa nigra, a risk for the development of pterygium and myopia: a descriptive cross-sectional study in Ghana

“…Hence, a larger prospective sample size using DPN subjects at other geographical areas is warranted to confirm our findings. Sun exposure associated with occupation or outdoor occupation has been widely acclaimed as a potential risk factor for the development of pterygium compared with indoor occupation (9,14,17,19,20). Observed results from our study also confirm the higher risk of developing pterygium with chronic exposure to sun outdoors compared to indoor occupation.…”

“…Age group, complexion and sun exposure were significantly associated with the incidence of pterygium in the facial DPN subjects. Previous studies have shown that age group (9,17), skin colour (14) and sun exposure (9,18) are associated with pterygium. This observation could partly be explained by the fact that cumulative UV exposure have been consistently linked with DPN (6) and pterygium (9,19), and both lesions tend to occur in adults with incidence increasing with age.…”

Prevalence of skin diseases among hostellers attending the tertiary care hospital

“…Dermatosis papulosa nigra has a strong family history. 19 Telogen effluvium is a condition with hair fall followed by acute stress. Hair loss due to telogen effluvium is seen in post-COVID patients.…”

Advances in the Etiology, Detection, and Clinical Management of Seborrheic Keratoses

“…DPN is found more often in African American, East Asian, and South Asian populations (Fitzpatrick IV-VI) with a consistently reported predominance in women and is thought to be underrecognized [33][34][35][36]. There is a high likelihood of family history, especially in individuals with large numbers of lesions [37][38][39][40][41]. Autosomal dominant inheritance with incomplete penetrance has been proposed [11,40,42].…”