128 Diagnostic Significance of [-2] Propsa Total and Transition Zone Prostate Volume Adjusted Psa-Related Indices in Japanese Men With Total Psa in the 2.0 to 10. Ong/Ml Range

PSA, PSA derivatives, proPSA and prostate health index in the diagnosis of prostate cancer

“…Degrees of specificity were 89, and 81% for p2PSA, and phi, respectively. [14,39,[47][48][49] In this meta-analysis, in patients with tPSA levels between 2-4, and 4-10 ng/mL, % p2PSA, and phi appeared to have comparable performances. [14] In most of the studies, AUC of % fPSA was higher than that of % p2PSA.…”

“…Cut-off values for % p2PSA with a 90% sensitivity were reported as 2.5% (Mikolajczyk et al [39] ), and 1.06 % (Miyakubo et al [47] ), while comparable cutoff values of phi with also 90% sensitivity were reported by Miyakubo et al [47] (24.5%), and Catalona et al [48] (21.1%) as indicated in parentheses. Catalona indicated that [48] , PHI does not change with age, and so it can be easily used to detect PCa in youngsters, and the elderly.…”

Clinical utility of the (-2)proPSA and evaluation of the evidence: a systematic review

“…Of these, 13 were excluded because: i) diagnostic accuracy data was not reported (n = 7); ii) definition of reference range was not reported (n = 2); male patients suspected of PCa were not included (n = 3); iii) (-2)pPSA was not considered (n = 1). A total of 17 studies [1,4,[10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] were included in the current analysis (Supplemental Material, Figure 1). …”

“…All studies used the prostate biopsy to diagnose PCa, and only four studies specified the tPSA as reference standard whose results were compared with the (-2)proPSA. In 15 studies, all patients underwent first serum biomarkers determination and then prostate biopsy [1,4,[10][11][12][13][14][15][16][18][19][20][21][22][23][24]. One study extended their research through an active surveillance program, of patients with a negative biopsy and with increasing PSA values [17].…”

“…Prostate cancer (PCa) is the main cause of worldwide death in men and its great prevalence is due to inappropriate life custom and environmental risk factors, as well as genetic factors [1]. Prostate specific antigen (PSA) is the marker used for screening the male population at risk of PCa, although being unspecific for this cancer.…”