125I-labelled fibrinogen in the diagnosis of deep-vein thrombosis and its correlation with phlebography

The whole blood clotting time, plasma fibrinogen and individual coagulation factors II, V, VII, VIII, IX, X, XI and XII were serially measured in 14 patients over a 10-day period following acute myocardial infarction. A further six patients with similar symptoms but without evidence of myocardial infarction were also studied. The whole blood clotting time was significantly shorter within the first 24 h after infarction than on subsequent days. There were significant increases in the levels of fibrinogen and of factors VIII, IX and XI and a significant decrease in factor XII in the patients who had sustained a myocardial infarction. The patients without myocardial infarction had no significant change in any of the coagulation factors measured.

Section: Discussionmentioning

confidence: 99%

Changes in Coagulation Factors Following Acute Myocardial Infarction in Man

Rennie¹,

Ogston²

1976

“…Using the m I-labelled fibrinogen test, an accu rate and objective method of detecting thrombi [4,10,13], several trials have now shown that DVT occurs frequently in patients undergoing total hip replacement. The present study has confirmed these findings.…”

Section: Discussionmentioning

confidence: 99%

Controlled Trial of Platelet Anti-Aggregating Agents and Subcutaneous Heparin in Prevention of Postoperative Deep Vein Thrombosis in High Risk Patients

Dechavanne¹,

Ville²,

Viala³

et al. 1975

In a prospective randomised trial, three groups of 20 patients each were compared. A first group served as a control, a second group received dipyridamole and acetylsalicylic acid and a third group received low doses of heparin. The incidence of deep vein thrombosis determined by the ¹²⁵I-fibrinogen test was 40 % in the first group, 50 % in the second group, and 5 % in the third group. The differences between the heparin group and the two other groups are statistically significant. No wound complication and no haematoma at the injection site occurred.

“…RFUT interpretation is based on data from clinical studies comparing this method with venography [71][72][73]. Radioactivity, ex pressed as a percentage of the heart count, is compared for adjacent points, and between corresponding points on the contralateral leg.…”

Section: The 125l-fibrinogen Uptake Testmentioning

confidence: 99%

Diagnostic Methods for Deep Vein Thrombosis

Wheeler¹,

Anderson²

1995

Clinical diagnosis of deep vein thrombosis (DVT) is unreliable, and treatment should not be undertaken without objective confirmation. The traditional ‘gold standard’ for the diagnosis of DVT has been venography, but ultrasonic imaging has now replaced venography as the new diagnostic standard in many hospitals. A variety of noninvasive physiologic tests are also useful in selected circumstances. These include plethysmography, Doppler flow studies, radioisotope tests, thermography and peripheral blood tests which reflect activation of coagulation or thrombolysis. We describe the clinical application of these diagnostic procedures, both for symptomatic patients suspected to have DVT and for asymptomatic patients at high risk for DVT. The selection of an appropriate diagnostic modality depends upon institutional capabilities, cost-effectiveness and individual patient circumstances.