125i-Labelled Fibrinogen in Cerebral Malaria

Devakul, Kanjika; Harinasuta, T; Reid, H. A.

doi:10.1016/s0140-6736(66)91982-9

Cited by 62 publications

(16 citation statements)

References 3 publications

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“…Different mechanisms are postulated including lysis, splenic sequestration, phagocytosis of platelets or decreased production from the marrow. [5] Disseminated intravascular coagulation was also suggested to be responsible for thrombocytopenia [14,15] but it was later shown that most patients with malaria do not have disseminated intravascular coagulation. [16] A direct interaction with platelets and plasmodium has been suggested as plasmodium vivax has been demonstrated by electron microscopy to exist inside the platelets with vivax malaria.…”

Section: Discussionmentioning

confidence: 99%

“…It was difficult to ascertain whether anaemia was due to malaria or some other disease like nutritional deficiency anaemia or worm infestation or gastrointestinal bleeding as previous reports of haemoglobin were not available in most of the patients. Many workers have reported high incidence of anaemia [25,26,27] in falciparum malaria. Normocytic and normochromic morphology of red blood cells was observed in 78% of cases which was similar to findings of White NJ et al [28] The pathophysiology of anaemia in malaria could be multifactorial envolving a complex series of interactions envolving destruction of parasitized red blood cells, ineffective erythropoiesis or immune mechanisms.…”

Section: Discussionmentioning

confidence: 99%

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Importance of Malarial Exclusion in a Thrombocytopenic Febrile Patient in an Endemic Area

Goel¹,

Vishwanathan²,

Mitra³

et al. 2015

jemds

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AIM OF THE STUDY:To evaluate the role of platelet count for predicting malarial infection and to determine the frequency and severity of thrombocytopenia in malarial parasite positive patients. STUDY DESIGN: The study included 150 patients who presented with fever in Santosh Medical College and Hospital, Ghaziabad. 97 patients with malaria were identified, rest were taken as control. Infection with both plasmodium vivax and plasmodium falciparum species was included. Thrombocytopenia was defined as platelet count less than 150000/cmm. RESULTS: Among 97 patients positive for malarial parasite, 78[80%] were found to have thrombocytopenia Overall 86 patients had plasmodium vivax while 8 patients had plasmodium falciparum infection and 3 had mixed infection. The frequency of thrombocytopenia was 78% [n=67] in vivax and 88% [n=7] in falciparum infection. Our study found the sensitivity of platelet count for diagnosing malaria was 80% and the specificity was 85%. Positive predictive value was 91% and negative predictive value was 83%. CONCLUSION: Platelet count can serve as an important initial screening tool in our setting. A finding of thrombocytopenia should increase the suspicion of malaria and more specific tests should be performed. Thrombocytopenia was a common haematological finding in patients with plasmodium infection, however its presence is not a distinguishing feature between the two types of malaria. Severe thrombocytopenia can occur in plasmodium vivax malaria although it is more common in plasmodium falciparum malaria.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Importance of Malarial Exclusion in a Thrombocytopenic Febrile Patient in an Endemic Area

Goel¹,

Vishwanathan²,

Mitra³

et al. 2015

jemds

View full text Add to dashboard Cite

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“…Several factors, including various chemical mediators, dehydration, toxic damage to tubules due to intravascular hemolysis and hemoglobinuria, direct toxic effect of severe hyperbilirubinemia, cytoadherence of parasitized erythrocytes, disseminated intravascular coagulation, sepsis, and hyperparasitemia leading to impaired microcirculation in peritubular capillary network, have been implicated in the pathogenesis of the renal failure in malaria. [10][11][12][13][14][15] Acute tubular necrosis is the principal pathologic mechanism in malaria-induced renal failure, whereas acute glomerulonephritis and acute interstitial nephritis are less commonly observed. This study was conducted including the patients suffering from malarial AKI, to describe the clinical characteristics, laboratory parameters and outcome of malarial AKI.…”

Section: Introductionmentioning

confidence: 99%

Outcome of malaria-associated acute kidney injury: a prospective study from a single center

et al. 2013

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“…Active platelet extractions have been found to be phospholipids, a platelet factor 3 (PF-3) which becomes available to the coagulant enzymes and cofactor at various stages of haemostasis. Many investigators [2][3][4][5][6][7] have observed marked alteration in haemostatic functions in malaria including thrombocytopaenia and bleeding disorders as a result of coagulation factors. Anaemia is an almost inevitable consequence of malaria infection but its pathophysiology is complex and has relatively little in common with anaemia of other infections 4 .…”

Section: Introduction: According To Marcfaclenementioning

confidence: 99%

Untitled

2011

IJPSR

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Background and Objective: Malaria, a formidable global parasitic infection represent a major health problem in tropical countries in terms of geographical spread, high morbidity, severe mortality especially among children. This study investigated platelet function's role and its strength to make platelet factor 3 (PF-3) available for coagulation in children with cerebral malaria. Subjects and Methods: Packed cell volume, platelet aggregate, platelet count and platelet factor-3 were studied in 65 children with, cerebral malaria and 50 healthy control children (Both group were aged 1-9 years). Results: Packed cell volume, platelet count were significantly lower (P<0.01) in children with malaria and platelet factor-3 was significantly higher (P<0.01) in children with cerebral malaria compared to normal children (controls). There was no significant level of platelet aggregate between children with cerebral malaria and control. Conclusion: Although the pathological roles of platelet function abnormalities in cerebral malaria infection is controversial but our study conclude that cerebral malaria infection is associated with thrombocytopenia and the increase of platelet factor-3 availability, with presence of platelet aggregates, may lead to hypercoagulability and various bleeding complications in children.

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125i-Labelled Fibrinogen in Cerebral Malaria

Cited by 62 publications

References 3 publications

Importance of Malarial Exclusion in a Thrombocytopenic Febrile Patient in an Endemic Area

Importance of Malarial Exclusion in a Thrombocytopenic Febrile Patient in an Endemic Area

Outcome of malaria-associated acute kidney injury: a prospective study from a single center

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