Abstract:The healthcare field has long been promised a number of exciting and powerful applications of Artificial Intelligence (AI) to improve the quality and delivery of health care services. AI techniques, such as machine learning (ML), have proven the ability to model enormous amounts of complex data and biological phenomena in ways only imaginable with human abilities alone. As such, medical professionals, data scientists, and Big Tech companies alike have all invested substantial time, effort, and funding into the… Show more
“…For an AI-based prediction model in medicine, clinicians expect more than to transfer valuable decision-making process of experienced surgeons to the model. The ability to present larger amounts of interpretable information is of great importance to augment surgeons' clinical judgements and gain their trust [ 13 ]. When the diagnosis or treatment planning are inconsistent among different doctors, it is important that an AI-based model can provide valuable information to assist decision and decrease biases [ 14 ].…”
Background
Preoperative planning of orthognathic surgery is indispensable for achieving ideal surgical outcome regarding the occlusion and jaws' position. However, orthognathic surgery planning is sophisticated and highly experience-dependent, which requires comprehensive consideration of facial morphology and occlusal function. This study aimed to investigate a robust and automatic method based on deep learning to predict reposition vectors of jawbones in orthognathic surgery plan.
Methods
A regression neural network named VSP transformer was developed based on Transformer architecture. Firstly, 3D cephalometric analysis was employed to quantify skeletal-facial morphology as input features. Next, input features were weighted using pretrained results to minimize bias resulted from multicollinearity. Through encoder-decoder blocks, ten landmark-based reposition vectors of jawbones were predicted. Permutation importance (PI) method was used to calculate contributions of each feature to final prediction to reveal interpretability of the proposed model.
Results
VSP transformer model was developed with 383 samples and clinically tested with 49 prospectively collected samples. Our proposed model outperformed other four classic regression models in prediction accuracy. Mean absolute errors (MAE) of prediction were 1.41 mm in validation set and 1.34 mm in clinical test set. The interpretability results of the model were highly consistent with clinical knowledge and experience.
Conclusions
The developed model can predict reposition vectors of orthognathic surgery plan with high accuracy and good clinically practical-effectiveness. Moreover, the model was proved reliable because of its good interpretability.
“…For an AI-based prediction model in medicine, clinicians expect more than to transfer valuable decision-making process of experienced surgeons to the model. The ability to present larger amounts of interpretable information is of great importance to augment surgeons' clinical judgements and gain their trust [ 13 ]. When the diagnosis or treatment planning are inconsistent among different doctors, it is important that an AI-based model can provide valuable information to assist decision and decrease biases [ 14 ].…”
Background
Preoperative planning of orthognathic surgery is indispensable for achieving ideal surgical outcome regarding the occlusion and jaws' position. However, orthognathic surgery planning is sophisticated and highly experience-dependent, which requires comprehensive consideration of facial morphology and occlusal function. This study aimed to investigate a robust and automatic method based on deep learning to predict reposition vectors of jawbones in orthognathic surgery plan.
Methods
A regression neural network named VSP transformer was developed based on Transformer architecture. Firstly, 3D cephalometric analysis was employed to quantify skeletal-facial morphology as input features. Next, input features were weighted using pretrained results to minimize bias resulted from multicollinearity. Through encoder-decoder blocks, ten landmark-based reposition vectors of jawbones were predicted. Permutation importance (PI) method was used to calculate contributions of each feature to final prediction to reveal interpretability of the proposed model.
Results
VSP transformer model was developed with 383 samples and clinically tested with 49 prospectively collected samples. Our proposed model outperformed other four classic regression models in prediction accuracy. Mean absolute errors (MAE) of prediction were 1.41 mm in validation set and 1.34 mm in clinical test set. The interpretability results of the model were highly consistent with clinical knowledge and experience.
Conclusions
The developed model can predict reposition vectors of orthognathic surgery plan with high accuracy and good clinically practical-effectiveness. Moreover, the model was proved reliable because of its good interpretability.
“…However, the current work provides a more detailed cortical model of the ROIs and connections involved in the SN by utilizing combined structural and functional neuroimaging studies in the literature and by describing our results according to the detailed HCP parcellation scheme (Glasser et al., 2016 ). Unfortunately, the structural interconnectedness of the SN has previously remained underspecified despite both its increasing body of research over previous years and the large advancements in neuroimaging technologies made in the neuroscience community (Doyen & Dadario, 2022 ; Menon, 2015 ). Such precision and clarity of the structural white matter connectivity of the SN are necessary to better understand the essential functions of the SN according to individual neural substrates and how to navigate this region with clinical applications (Menon, 2011 ; Rosen et al., 2021 ).…”
Background:The salience network (SN) is a transitory mediator between active and passive states of mind. Multiple cortical areas, including the opercular, insular, and cingulate cortices have been linked in this processing, though knowledge of network connectivity has been devoid of structural specificity.
Objective:The current study sought to create an anatomically specific connectivity model of the neural substrates involved in the salience network.Methods: A literature search of PubMed and BrainMap Sleuth was conducted for resting-state and task-based fMRI studies relevant to the salience network according to PRISMA guidelines. Publicly available meta-analytic software was utilized to extract relevant fMRI data for the creation of an activation likelihood estimation (ALE) map and relevant parcellations from the human connectome project overlapping with the ALE data were identified for inclusion in our SN model. DSI-based fiber tractography was then performed on publicaly available data from healthy subjects to determine the structural connections between cortical parcellations comprising the network.Results: Nine cortical regions were found to comprise the salience network: areas AVI (anterior ventral insula), MI (middle insula), FOP4 (frontal operculum 4), FOP5 (frontal operculum 5), a24pr (anterior 24 prime), a32pr (anterior 32 prime), p32pr (posterior 32 prime), and SCEF (supplementary and cingulate eye field), and 46. The frontal aslant tract was found to connect the opercular-insular cluster to the middle cingulate clusters of the network, while mostly short U-fibers connected adjacent nodes of the network.
Conclusion:Here we provide an anatomically specific connectivity model of the neural substrates involved in the salience network. These results may serve as an empiric basis for clinical translation in this region and for future study which seeks to expand ourThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
“…Artificial Intelligence (AI) techniques, like machine learning, have increased in popularity because of their proven ability to model large amounts of complex data and biological phenomena. Consequently, big tech companies, data scientists, medical professionals, and nearly every large workplace is investing more resources to deploy these technologies (Doyen & Dadario, 2022). However, deploying these technologies without proper evaluation in complex socio-technical environments can have enormous consequences for end users within these organizations.…”
Adoption and use of misspecified models can lead to impoverished decision-making—a phenomenon we term model blindness. A series of two experiments investigated the consequences of model blindness on human decision-making and performance and how those consequences can be mitigated via an explainable AI (XAI) intervention. The experiments implemented a simulated route recommender system as a Decision Support System (DSS) with a true data-generating model. In Experiment 1, the true model generating the recommended routes was misspecified at two different levels to impose model blindness on users. In Experiment 2, the same route-recommender system was augmented with a mitigation technique to overcome the impact of model-misspecifications on decision-making. Overall, the results of both experiments provided little support for performance degradation. The participants' decision strategies revealed that they could understand model limitations from feedback and explanations and could adapt their strategy to account for those misspecifications.
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