1061 Sleep Duration Associates With Metabolic and Non-Metabolic Diseases Curated From Electronic Medical Records in the Partners Biobank

Abstract

or more medications from different classes, including a diuretic. We have previously reported that patients with rHTN exhibit heightened sympathetic tone when compared with those with crHTN. Therefore, this study sought to investigate sleep as a potential mediating mechanism underlying rHTN. We hypothesized that patients with rHTN would have more severe obstructive sleep apnea (OSA) than patients with crHTN as a contributing factor to their heightened sympathetic tone. Methods: Consecutive patients (n=80) from the UAB Hypertension Clinic with either rHTN (n=29) or crHTN (n=51) were evaluated by overnight polysomnography. Multivariate analysis of variance was used to compare sleep characteristics between these two groups of patients. Results: Compared with patients with crHTN, those with rHTN were younger (54.6 ± 9.9 versus 58.1 ± 11.6 years) and more likely to be black (75.9% versus 54.9%) and female (69.0% versus 37.3%). Patients with rHTN had more total sleep time (p=0.017) and more time spent in N2 sleep (p=0.002). There were no other significant differences in sleep architecture, number of awakenings, or time spent awake after sleep onset. Patients with rHTN had a higher sleeping heart rate (p=0.040). There were statistically non-significant trends for patients with rHTN to have a higher mean apnea hypopnea index (AHI), as well as for a larger percentage of these patients to have an AHI>5, although these trends were not statistically significant (p=0.367). Conclusion: These findings indicate that patients with rHTN do not exhibit worse OSA compared with patients with crHTN. Therefore, more severe OSA does not explain the heightened sympathetic tone observed in patients with rHTN. Support (If Any): This study was supported by NIH grant R01 HL113004 and grant 15SFRN2390002 from the American Heart Association. EFFECT OF AGE ON THE ASSOCIATION BETWEEN SUBJECTIVE SLEEP QUALITY AND METABOLIC SYNDROME Introduction:Many previous studies have reported that self-reported global sleep quality and sleep duration are significantly related to the metabolic syndrome (MetS). However, it is no clear how chronological age affects the association between sleep quality and MetS and thus the aim of this study is to investigate age effect on this relationship. Methods: The cross-section baseline data of adult men and women (n=22,995, 23-79yr) were collected from health check-up study, including Pittsburgh Sleep Quality Index (PSQI) with concurrently collected components of MetS. Results: Poor sleep quality (PSQI≥6) and shorter sleep duration showed significant association in people with MetS than those without (20.9% vs 19.0%, p=0.004) after adjusting for age, smoking, alcohol, sex, and exercise. To better clarify the age effect, we classified them by the median age 40 y.. Among the older (> 40 y), global PSQI score was significantly higher (p=0.002) and sleep duration was shorter (p=0.007) in subjects with MetS compared to in those without

Sleep duration and breast cancer incidence: results from the Million Women Study and meta-analysis of published prospective studies

“…Of these, 19 full-text articles were assessed for eligibility. Six records were excluded, two of which lacked the exposure of interest [ 27 , 28 ], one involved a patient population [ 29 ], one reported results that were updated in a subsequent publication [ 30 ], one did not provide sufficient information [ 31 ], and one had no full-text available [ 32 ]. One additional study was found online that was not identified through keyword searches in Embase and MEDLINE.…”

Associação entre curta duração do sono e obesidade: uma revisão sistemática e meta-análise de estudos de coorte

“…After reading the full text, twelve studies were excluded -five crosssectional studies, [66][67][68][69][70] four studies with outcome different from the interest, [71][72][73][74] two studies with adolescents 75,76 , and one that included pregnant women. 77 Four studies was included by hand search and 36 studies were included in this systematic review [11][12][13][15][16][17][18][19][20][21][22][23][66][67][68][69][70][71][72][73][74][77][78][79][80][81][82][83][84][85][86][87][88][88][89][90][91][92]…”