Statistical analysis for efficacy of tirofiban combined with ozagrel in the treatment of progressive cerebral infarction patients out of thrombolytic therapy time window

Zhang, Huiying; Zheng, Lei

doi:10.6061/clinics/2021/e2728

Cited by 7 publications

(2 citation statements)

References 30 publications

(27 reference statements)

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“…A total of 80 patients with ischemic stroke who were hospitalized in Zhoushan Hospital from October 2019 to May 2022 were included in the study, including 40 patients with PCI and 40 patients with NPCI. The inclusion criteria were as follows: (1) patients admitted to the Acute Stroke Unit within 24 h of CI onset; (2) age ≥18 years with no previous stroke history; (3) PCI was defined as the neurological deficits that did not show any improvement and continued to progress within 1 week under regular treatment, with the NIHSS score increased by at least 2 points 13,14 . The exclusion criteria were as follows: (1) patients with severe impairment of consciousness, transient ischemic attack, hemorrhagic stroke, subarachnoid hemorrhage, intracranial infection, intracranial hemorrhage, intracranial tumor, trauma, or neurodegenerative disease; (2) severe cardiac, hepatic, and renal insufficiency; (3) comorbid hematologic disease, malignancy, autoimmune disease; (4) more than two consecutive BP recordings missing (i.e., with any interval more than 4 h between recordings).…”

Section: Methodsmentioning

confidence: 99%

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Hemodynamic changes in progressive cerebral infarction: An observational study based on blood pressure monitoring

Li,

Wu,

Dong

et al. 2024

J of Clinical Hypertension

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Progressive cerebral infarction (PCI) is a common complication in patients with ischemic stroke that leads to poor prognosis. Blood pressure (BP) can indicate post‐stroke hemodynamic changes which play a key role in the development of PCI. The authors aim to investigate the association between BP‐derived hemodynamic parameters and PCI. Clinical data and BP recordings were collected from 80 patients with cerebral infarction, including 40 patients with PCI and 40 patients with non‐progressive cerebral infarction (NPCI). Hemodynamic parameters were calculated from the BP recordings of the first 7 days after admission, including systolic and diastolic BP, mean arterial pressure, and pulse pressure (PP), with the mean values of each group calculated and compared between daytime and nighttime, and between different days. Hemodynamic parameters and circadian BP rhythm patterns were compared between PCI and NPCI groups using t‐test or non‐parametric equivalent for continuous variables, Chi‐squared test or Fisher's exact test for categorical variables, Cox proportional hazards regression analysis and binary logistic regression analysis for potential risk factors. In PCI and NPCI groups, significant decrease of daytime systolic BP appeared on the second and sixth days, respectively. Systolic BP and fibrinogen at admission, daytime systolic BP of the first day, nighttime systolic BP of the third day, PP, and the ratio of abnormal BP circadian rhythms were all higher in the PCI group. PCI and NPCI groups were significantly different in BP circadian rhythm pattern. PCI is associated with higher systolic BP, PP and more abnormal circadian rhythms of BP.

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Section: Methodsmentioning

confidence: 99%

“…(3) PCI was defined as the neurological deficits that did not show any improvement and continued to progress within 1 week under regular treatment, with the NIHSS score increased by at least 2 points. 13,14 The exclusion criteria were as follows: (…”

mentioning

confidence: 99%

Hemodynamic changes in progressive cerebral infarction: An observational study based on blood pressure monitoring

Li,

Wu,

Dong

et al. 2024

J of Clinical Hypertension

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Neuroprotective effect of exosomes derived from bone marrow mesenchymal stem cells via activating TGR5 and suppressing apoptosis

Liu

Li²,

Ye³

et al. 2022

Biochemical and Biophysical Research Communications

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Effects of borneol combined with astragaloside IV and Panax notoginseng saponins regulation of microglia polarization to promote neurogenesis after cerebral ischaemia

Ding

Huang

Liu

et al. 2023

Journal of Pharmacy and Pharmacology

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Objective To study the effect of borneol combined with astragaloside IV and Panax notoginseng saponins (BAP) on promoting neurogenesis by regulating microglia polarization after cerebral ischaemia–reperfusion(CI/R) in rats. Methods A focal CI/R injury model was established. Evaluated the effects of BAP on ischaemic brain injury, on promoting neurogenesis, on inhibiting Inflammatory microenvironment and TLR4/MyD88/NFκB signalling pathway. A microglia oxygen-glucose deprivation reoxygenation (OGD/R) model was established that evaluated the effects of BAP on regulating the polarization of microglia and inflammatory microenvironment. Results BAP can inhibit the expression of TLR4, MyD88 and NFκB proteins, reduce IL-1β and increase IL-10, reduce M1 type microglia and increase M2 microglia. The proliferation of neural stem cells increased, synaptic gap decreased, synaptic interface curvature increased, expression of SYN and PSD95 proteins increased, which improved the neurological dysfunction and reduced the volume of cerebellar infarction and nerve cell injury. Conclusion BAP can reduce CI/R injury and promote neurogenesis, the effect is related to inhibition of the activation of TLR4/MyD88/NFκB, regulating the polarization of microglia from M1 type to M2 type and inhibition of inflammatory response.

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Statistical analysis for efficacy of tirofiban combined with ozagrel in the treatment of progressive cerebral infarction patients out of thrombolytic therapy time window

Abstract: Zhang H, Zheng L. Statistical analysis for efficacy of tirofiban combined with ozagrel in the treatment of progressive cerebral infarction patients out of thrombolytic therapy time window. Clinics (Sao Paulo).

Cited by 7 publications

References 30 publications

Hemodynamic changes in progressive cerebral infarction: An observational study based on blood pressure monitoring

Hemodynamic changes in progressive cerebral infarction: An observational study based on blood pressure monitoring

Neuroprotective effect of exosomes derived from bone marrow mesenchymal stem cells via activating TGR5 and suppressing apoptosis

Effects of borneol combined with astragaloside IV and Panax notoginseng saponins regulation of microglia polarization to promote neurogenesis after cerebral ischaemia

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