2020
DOI: 10.6061/clinics/2020/e1546
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Abstract: OBJECTIVES: High incidence and case fatality of unstable angina (UA) is, to a large extent, a consequence of the lack of highly sensitive and specific non-invasive markers. Circulating microRNAs (miRNAs) have been widely recommended as potential biomarkers for numerous diseases. In the present study, we characterized distinctive miRNA expression profiles in patients with stable angina (SA), UA, and normal coronary arteries (NCA), and identified promising candidates for UA diagnosis. … Show more

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Cited by 4 publications
(3 citation statements)
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“…With regard to the subtype of MI, Ward et al reported that miR-25-3p, miR-221-3p, and miR-374b-5p were strongly correlated with ST-Elevation Myocardial Infarction (STEMI), while miRs-221-3p and -483-5p were highly associated with non-ST-Elevation Myocardial Infarction (NSTEMI) [ 135 ]. The upregulation of a few other miRNAs (miR-134, miR-198, and miR-370) was uniquely linked to unstable angina (UA) compared to stable CAD, and can facilitate the diagnosis of UA, which can be elusive in some patients with normal troponin values [ 136 ].…”
Section: The Clinical Implementation Of the Biomarker Mirna Network I...mentioning
confidence: 99%
“…With regard to the subtype of MI, Ward et al reported that miR-25-3p, miR-221-3p, and miR-374b-5p were strongly correlated with ST-Elevation Myocardial Infarction (STEMI), while miRs-221-3p and -483-5p were highly associated with non-ST-Elevation Myocardial Infarction (NSTEMI) [ 135 ]. The upregulation of a few other miRNAs (miR-134, miR-198, and miR-370) was uniquely linked to unstable angina (UA) compared to stable CAD, and can facilitate the diagnosis of UA, which can be elusive in some patients with normal troponin values [ 136 ].…”
Section: The Clinical Implementation Of the Biomarker Mirna Network I...mentioning
confidence: 99%
“…Liu et al [ 37 ] reported that different miRNAs are upregulated both in stable and unstable angina (UA) compared with subjects with normal coronary arteries; in particular, they suggest that these circulating miRNAs could be used as potential biomarkers of UA. Ling et al [ 36 ] reported that miR-21 (less expressed compared with controls) and miR-126 (more expressed compared to controls) could be useful markers for predicting AMI and UA.…”
Section: Resultsmentioning
confidence: 99%
“…More specifically, older and recent evidence point out the potential role of miRNAs as novel biomarkers not only in STEMI, but also in STEMI's secondary complication such as LVR or HF (Table 1), , or even their use as promising new therapeutic targets [180,181] (Table 2). More than that, miRNAs have the potential to be used in the differential diagnosis of ACS [17,182] with: unstable angina [183], NSTEMI [94,184], and acute myocarditis [185]. Exploration of patients with STEMI and patients with Takotsubo cardiomyopathy (TTC), established that miR-133a was substantially increased subjects with STEMI compared with those with TTC.…”
Section: Discussionmentioning
confidence: 99%