Prediabetes and Type 2 Diabetes are Independent Risk Factors for Computed Tomography-Estimated Nonalcoholic Fatty Pancreas Disease

Ahbab, Süleyman; Ünsal, Ahmet; Ataoğlu, Hayriye Esra; Can, Tuba Selçuk; Kayas, Derya; Savas, Yildiray

doi:10.6061/clinics/2019/e1337

Cited by 8 publications

(6 citation statements)

References 34 publications

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“…(14) Similarly, Lim et al (15) stated that T2DM patients had excessive pancreatic fat content, compared to normoglycemic subjects. Ahbab et al (16) reported that DM correlated with a decrease in the mean HU values of the pancreas (P=0.002). These decreased attenuation values were attributed to the fact that pancreatic fat content increased in T2DM, resulting in increased fat content in the pancreatic tissue.…”

Section: Discussionmentioning

confidence: 97%

Evaluation of Liver in Type 2 Diabetes Mellitus Using Unenhanced Computed Tomography

Osama¹,

Siddig²,

Gareeballah³

et al. 2020

IJBM

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Background: Chronic liver disease occurs due to different etiologies. Most diabetic patients are unaware that the effective control of hyperglycemia might reduce complications and mortality rates. Fatty liver disease is considered a risk factor of hepatic cirrhosis and cancers. Methods and Results: We conducted a case-control study to assess the impact of type 2 diabetes mellitus (T2DM) on the liver using a CT scan. A total of 100 patients with T2DM and 96 non-diabetic patients as a control group were selected using a convenient sampling method. There was a significant difference in liver attenuation in diabetic and control groups. The CT attenuation values of the liver, pancreas, and spleen were significantly lower in patients with T2DM than in non-diabetics (P<0.001). There was a significant negative correlation between the duration of T2DM and CT attenuation of the liver, pancreas, and spleen (P<0.01). Conclusion: The CT attenuation of the liver was significantly lower in T2DM than in the non-diabetic patients, and liver attenuation decreased as the duration of T2DM increased.

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Section: Discussionmentioning

confidence: 97%

Evaluation of Liver in Type 2 Diabetes Mellitus Using Unenhanced Computed Tomography

Osama¹,

Siddig²,

Gareeballah³

et al. 2020

IJBM

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“…4 On the other hand, in other studies excluding or rarely including patients with diabetes, intrapancreatic fat deposition was related to liver fat. 26 27 As it has been reported that the intrapancreatic fat deposition in patients with diabetes was higher than in patients without diabetes, 19 the inconsistency of the associations might be due to patient characteristics (with type 2 diabetes in our study and without diabetes in other studies). In the current dietary guidelines for patients with diabetes, skipping meals is not recommended 28 because this worsens glycemic control 29 and increases the risk of arteriosclerosis.…”

Section: Discussionmentioning

confidence: 70%

Consumption of two meals per day is associated with increased intrapancreatic fat deposition in patients with type 2 diabetes: a retrospective study

Niki

Baden

Kato

et al. 2022

BMJ Open Diab Res Care

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IntroductionThis study aimed to identify the associations between lifestyle factors and intrapancreatic fat deposition in patients with type 2 diabetes.Research design and methodsThe participants were 185 patients with type 2 diabetes who were hospitalized at Osaka University Hospital between 2008 and 2020 and underwent abdominal CT during hospitalization. Information regarding lifestyle factors, including the number of meals consumed per day, snacking habits, exercise habits, exercise at work, smoking habits, alcohol intake, insomnia, sleep apnea syndrome, and night-shift working, was acquired from self-administered questionnaires or medical records. We measured the mean CT values for the pancreas (P), liver (L), and spleen (S), and the visceral fat area (VFA), and quantified intrapancreatic and liver ectopic fat accumulation as P−S and L−S, respectively.ResultsAfter adjustment for age, sex, hemoglobin A1c, and body mass index (BMI), participants who consumed two meals per day had significantly lower P−S (higher intrapancreatic fat deposition, p=0.02) than those who consumed three meals per day. There were no significant associations between the number of meals consumed and liver ectopic fat accumulation and VFA (p=0.73 and p=0.67, respectively).ConclusionsPatients with diabetes who consumed two meals per day showed greater intrapancreatic fat deposition than those who consumed three meals per day, even after adjustment for BMI. These findings support the current guideline for diabetes treatment that skipping meals should be avoided.

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“…A high-fat diet damages normal rat pancreas with fat deposition, 35 and circulating TG, glycated hemoglobin, insulin, and HOMA-IR yield positive correlations with human pancreatic fat deposition. 36 Some reports have shown that NAFPD is associated with decreased P-amylase levels, 37,38 whereas one study has shown that increased P-amylase levels are associated with the severity of NAFPD graded by pancreatic echogenicity on abdominal ultrasonography. 39 In the present study, there was an increasing trend for the proportion of NAFPD with decreasing P-amylase quartiles, which was not significant; however, the correlation with NAFLD was significant.…”

Section: Discussionmentioning

confidence: 99%

Low serum pancreatic amylase levels as a novel latent risk factor for colorectal adenoma in non‐alcohol drinkers

Sasaki

Abe

Nishise

et al. 2021

J of Gastro and Hepatol

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Background and Aim: Obesity, insulin resistance, and metabolic alterations increase the risk of colorectal cancer and adenoma (CRA). Non-alcoholic fatty liver disease (NAFLD) or pancreatic disease (NAFPD) shares many risk factors with CRA that may have significant roles in its development; however, the relationship between CRA and NAFLD/NAFPD remains unclear. Methods: This cross-sectional study recruited 712 eligible participants without current drinking who had undergone total colonoscopy as part of a health checkup. These participants were classified into a CRA group (n = 236) and a control group (n = 439), which consisted of individuals without CRA and a history of polyp resection. NAFLD and NAFPD were diagnosed based on abdominal ultrasonography findings. Results: Non-alcoholic fatty liver disease was observed more frequently in individuals with CRA than in the control group (55.9% vs 41.6%, P < 0.01). There was no significant association between NAFPD and CRA; however, serum pancreatic amylase (P-amylase) levels were significantly lower in individuals with CRA. Although NAFLD was one of the factors increasing the presence of CRA (odds ratio [OR], 1.50; 95% confidence interval [CI], 1.07-2.10), low P-amylase levels were significantly associated with the presence of CRA (OR, 1.73; 95% CI, 1.04-2.88) independent of age, sex, current smoking, obesity, metabolic alterations including insulin resistance, and NAFLD. Conclusions: Low serum P-amylase levels were a possible independent risk factor for CRA in the present study. The latent pancreatic exocrine-endocrine-gut relationship was considered a novel pathway involved in obesity-related CRA development, in non-alcoholic individuals. † Regular use of any drugs, including insulin, agents for diabetes, hyperlipidemia, and hypertension. HB, hepatitis B; HCV, hepatitis C virus.

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Prediabetes and Type 2 Diabetes are Independent Risk Factors for Computed Tomography-Estimated Nonalcoholic Fatty Pancreas Disease

Cited by 8 publications

References 34 publications

Evaluation of Liver in Type 2 Diabetes Mellitus Using Unenhanced Computed Tomography

Evaluation of Liver in Type 2 Diabetes Mellitus Using Unenhanced Computed Tomography

Consumption of two meals per day is associated with increased intrapancreatic fat deposition in patients with type 2 diabetes: a retrospective study

Low serum pancreatic amylase levels as a novel latent risk factor for colorectal adenoma in non‐alcohol drinkers

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