Epidemiological profile of patients with preterm premature rupture of membranes at a tertiary hospital in São Paulo, Brazil

Galletta, Marco Aurélio Knippel; Bittar, Roberto Eduardo; Agra, Isabela Karine Rodrigues; Guerra, Eliane Cerqueira Leite; Francisco, Rossana Pulcineli Vieira; Zugaib, Marcelo

doi:10.6061/clinics/2019/e1231

Cited by 8 publications

(11 citation statements)

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“…Majority respondents were in age group 26-30 years (36.7%) with a mean age of 27.03 ±6.13 years. The average maternal age of our subjects showed similarity with that reported in some other studies; those values were 27.46 years in Galletta et al's study 16 26.36 years in Flores's study. 17 In contrast, our patients had a lower average maternal age than those reported by Dars et al 18 , 30 years by Frenette et al 19 , 29.7 years by Garite et al 20 Higher maternal age could be related to the more frequent presence of maternal diseases, such as hypertension and diabetes, or obstetric pathologies, such as twinning and fetal malformations.…”

Section: Discussionsupporting

confidence: 91%

Maternal and Fetal Outcome of Preterm Prelabor Rupture of the Membranes in a Tertiary Care Hospital

Khatun

Akter

Ali

2020

TAJ: J of Teachers Assoc

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Objective: To describe the clinical presentation and feto-maternal outcome of preterm prelabor rupture of the membrane of patients admitted in a tertiary care hospital of Bangladesh. Methods and Material: This is a cross-sectional observational type study carried out in Rajshahi Medical College Hospital, Rajshahi, Bangladesh during the year 2019 in the Department of Obstetrics and Gynecology. Sixty pregnant women with preterm prelabor rupture of the membrane (gestational age 28 to 37 weeks) were included in this study. Results: The mean age of the women was 27.03±6.13 years. Forty (66.7%) of them were from rural area. Majority were studied up to primary school (33.30%). Sixty five percent were house wife. Thirty seven (61.7%) women were multi gravid. Mean gestational age of the patient was 34.43±2.75 weeks. Antenatal care of the women was low. Most of the women have associated one or more diseases like anemia (35%), Urinary tract infection (28.33%), Pregnancy induced hypertension (20%), Lower genital infection (13.33 %,), gestational diabetes mellitus (10%) and heart disease (3.33%). The mean time interval between membrane rupture and delivery was 29±9 hours. Thirty one patients (51.7%) were delivered by caesarian section. Twenty eight (46.7%) women did not experience any complication and other suffered from wound infection (20%), PPH (10%), puerperal sepsis (8.33%) and chorioamnionitis (11.7%). Mean birth weight of the newborns was 2.16±0.42 Kg. Thirty eight (63.33%) newborn suffered from complications like neonatal asphyxia (30%), respiratory distress syndrome (13.3%), neonatal jaundice (11.7%) and neonatal sepsis (3.3%). Neonatal death was noticed in three (5%) cases. Fetal outcome was found significantly (p< 0.001) associated with low gestational age. Conclusion: Women with low education, associated co-morbidity, long latency and neonate with low birth weight have unfavorable outcome. Antenatal care is an important tool to prevent preterm prelabor rupture of the membrane by identifying the risk factors and its management. Optimum obstetric and medical care is essential for the reduction of these devastating complications. TAJ 2020; 33(2): 1-9

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Section: Discussionsupporting

confidence: 91%

Maternal and Fetal Outcome of Preterm Prelabor Rupture of the Membranes in a Tertiary Care Hospital

Khatun

Akter

Ali

2020

TAJ: J of Teachers Assoc

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“…Review of literature shows that among PPROM patients, the incidence of PPROM in previous pregnancies were 5.4%, 6.6% and 11.8% in studies by Silveira et al, Galletta et al, and Kilpatrick et al, respectively. [6][7][8] Getahun et al found that the risk of PPROM increased by a factor of 2 to 2.4 in patients of PPROM with previous history of PPROM. 9 In the present study, of the 89 multiparous women only 2.2% had history of PPROM in previous pregnancies.…”

Section: Discussionmentioning

confidence: 99%

“…respectively with far lesser rates in control group of Zhang et al (6.5%) suggesting GBS infection as a risk factor for PPROM. 7,[13][14][15] Hence some authors recommend chemoprophylaxis for GBS during intrapartum to decrease the incidence of early-onset neonatal GBS sepsis and mortality unless a negative perineal culture for GBS has been documented within the previous 5 weeks. 16 However, RCOG guidelines 2017 recommended routine use intrapartum antibiotic prophylasis for GBS irrespective of GBS carrier status.…”

Section: Discussionmentioning

confidence: 99%

Pregnancy outcome in preterm premature rupture of membranes between 24 to 34 weeks of gestation

Venkatraman

Chaturvedula

Parija

2020

Int J Reprod Contracept Obstet Gynecol

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Background: Preterm premature rupture of membranes (PPROM) is spontaneous rupture of the fetal membranes before 37 completed weeks and before onset of labour which complicates 3-5% of all pregnancies. Studies regarding PPROM in very early gestation are lacking. The primary objective was to assess the maternal and perinatal outcome in preterm premature rupture of membranes and secondary objective was to assess the colonization of group B Streptococci (GBS) and Listeria monocytogenes in patients with PPROM.Methods: This prospective study was performed on 175 antenatal women with PPROM between 24 to 34 weeks of gestation.Results: Majority of women (54.2%) were between 32 to 34 weeks of gestation, 37% were between 28 to 32 weeks of gestation and 7.8% were between 24 to 28 weeks of gestation. About 22 % of women had cervicovaginal infections. The prevalence of group B Streptococci in the study group was 1.2% and no isolates of Listeria. The most common maternal morbidity was puerperal fever (11.4 %). Among newborn babies 87 (55 %) required neonatal intensive care unit (NICU) admission mainly for respiratory distress and prematurity. With each week of increase in gestational age, there is decrease in latency period by 22 hours and duration of NICU stay nearly by one day.Conclusions: From the present study it may be concluded that PPROM is associated with genitourinary infection, puerperal pyrexia and respiratory distress syndrome among neonates. The prevalence of group B Streptococci in antenatal women with PPROM is very low and no Listeria were isolated.

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“…Previous studies have reported [35][36][37] that for PPROM patients who have fetal lung maturity and infection, simply extending the gestational week will not reduce the serious complications of preterm infants, but PPROM pregnant women have reduced amniotic fluid, higher incidence of chorioamnionitis and various inflammations in the amniotic fluid. The increase in substances can affect the growth and development of the fetus, causing the fetal body mass to not increase correspondingly with the growth of the gestational age.…”

Section: P R E P R I N Tmentioning

confidence: 99%

The role of latency period on the preterm premature rupture of membranes: implication for treatment

Lü

Gan

et al. 2021

Arch Med Sci

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IntroductionConservative treatments with latency period have been used for the treatment of preterm premature rupture of membranes (PPROM) in clinical practice, we aimed to evaluate the role and potential influencing factors of latency period, to provide insights to the clinical treatment of PPROM.Material and methodsPPROM pregnant women treated in our hospital from January 1, 2015 to September 30, 2020 were included. PPROM patients were divided into 48～168h group and the >168h latency group, the characteristics and prognosis of this two groups were compared and analyzed. Logistic regression analyses were conducted to analyze the relevant influencing factors of latency period.ResultsA total of 131 PPROM patients were included. There were significant differences on the age, BMI, gestational age on admission, amniotic fluid volume before childbirth, and positive rate of cervical secretion culture between two groups (all p<0.05). Logistic regression analyses indicated that the latency period was shorter in the PPROM patients with age≥30y(OR0.048, 95%CI0.121~0.863) and gestational age≥32w on admission(OR0.463, 95%CI0.069~0.811), and the latency period was prolonged in the PPROM patients with BMI≥23kg/㎡(OR1.591, 95%CI1.134~1.944) and amniotic fluid volume≥6cm(OR2.129, 95%CI1.093~3.042) (all p<0.05). There were significant differences in the incidence of low birth weight and NRDS between 48~168h group and >168h group (all p<0.05).ConclusionsLatency period plays an important role in the PPROM, which is associated with the pregnant women's age, BMI, gestational week of rupture and amniotic fluid index.

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Epidemiological profile of patients with preterm premature rupture of membranes at a tertiary hospital in São Paulo, Brazil

Cited by 8 publications

References 50 publications

Maternal and Fetal Outcome of Preterm Prelabor Rupture of the Membranes in a Tertiary Care Hospital

Maternal and Fetal Outcome of Preterm Prelabor Rupture of the Membranes in a Tertiary Care Hospital

Pregnancy outcome in preterm premature rupture of membranes between 24 to 34 weeks of gestation

The role of latency period on the preterm premature rupture of membranes: implication for treatment

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