Relationship between the biomechanical properties of the cornea and anterior segment measurements

Souza, Murilo Barreto; Medeiros, Fabrício Witzel de; Villela, Flávio Fernandes; Alves, Mílton Ruiz

doi:10.6061/clinics/2018/e491

Cited by 4 publications

(4 citation statements)

References 32 publications

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“…In Nemeth’s study, the corneal curvature was also related to the amplitude of corneal deformation and the time taken to reach this applanation [ 18 ]. On the contrary, several studies found that there was no significant correlation between the curvature and CH or CRF [ 45 , 47 , 48 ]. The correlation between corneal curvature and biomechanics needs further study.…”

Section: Discussionmentioning

confidence: 99%

Age distribution and associated factors of cornea biomechanical parameter stress-strain index in Chinese healthy population

et al. 2020

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Background To investigate the new cornea biomechanical parameter stress-strain index (SSI) in Chinese healthy people and the factors associated with SSI. Methods A total of 175 eyes from 175 participants were included in this study. Axial length was measured with the Lenstar LS-900. Pentacam measured curvature of the cornea and anterior chamber volume (ACV). Cornea biomechanical properties assessments were performed by corneal visualization Scheimpflug technology (Corvis ST). Student’s t-test, one-way ANOVA, partial least square linear regression (PLSLR) and linear mixed effects (LME) model were used in the statistical analysis. Results The mean (±SD) SSI was 1.14 ± 0.22 (range, 0.66–1.78) in all subjects and affected by age significantly after age of 35 (P < 0.05). In LME models, SSI was significantly associated with age (β = 0.526, P < 0.001), axial length (AL) (β = − 0.541, P < 0.001), intraocular pressure (IOP) (β = 0.326, P < 0.001) and steepest radius of anterior corneal curvature (RsF) (β = 0.229, P < 0.001) but not with ACV, biomechanical corrected intraocular pressure (bIOP), flattest radius of anterior corneal curvature (RfF) or central corneal thickness (CCT) (P > 0.05 for each). Conclusions SSI increased with age after the age of 35. In addition to age, SSI was positively correlated with RsF and IOP, while negatively correlated with AL.

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Section: Discussionmentioning

confidence: 99%

Age distribution and associated factors of cornea biomechanical parameter stress-strain index in Chinese healthy population

et al. 2020

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“…This is justified by the structural modifications of the collagen fibers that suffer a significant elongation under high IOP values, thus the difference between the P1 and P2 parameters at ORA is decreasing [ 23 - 26 ].…”

Section: Discussionmentioning

confidence: 99%

Correlations between corneal biomechanics and specular microscopy in patient with cataract

Iancu

Bujor

Iliuţă

et al. 2020

rjo

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This study aimed to analyze the connection between corneal biomechanics (corneal hysteresis, CH) and endothelial cell density of cornea (mean endothelial cell density, MCD) in patients diagnosed with cataract. This retrospective, observational study was performed in the Ophthalmology Clinic of the University Emergency Hospital in Bucharest. Of 60 patients (120 eyes) with cataract, who were included in this study, we analyzed the CH values obtained using with the Ocular Response Analyzer (ORA) and the MCD values obtained using the specular microscopy. The study groups comprised both men and women with ages ranging from 45 to 63 years. Patients were divided into three study groups according to CH values. In each batch, the CH values obtained with the Ocular Response Analyzer (ORA) were correlated with age, gender and MCD, then the subgroups were compared. All the data gathered showed no correlation to be statistically significant regarding the biomechanical properties of the cornea and the corneal endothelial cell density in patients with cataract.

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“…It was found that the radius of anterior and posterior curvature was positively correlated with biomechanics 14,42 . On the contrary, several studies found that there was no signi cant correlation between the curvature and CH or CRF 40,43,44 . The correlation between corneal curvature and biomechanics needs further study.…”

Section: Resultsmentioning

confidence: 92%

Age Distribution and Associated Factors of Cornea Biochemical Parameter Stress-Strain Index in Chinese Healthy Population

Liu

Hua

Pei

et al. 2020

Preprint

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Background: To investigate the new cornea biochemical parameter stress-strain index (SSI) in Chinese healthy people and the factors associated with SSIMethods: A total of 175 eyes from 175 participants were recruited in this study. Axial length was measured with the Lenstar LS-900. Pentacam was used to measure curvature of the cornea and ACV and cornea biomechanical properties were measured by corneal visualization Scheimpflug technology (Corvis ST). Student’s t-test, one-way ANOVA, univariate and multivariate linear regression were used in the statistical analysis.Results: The mean (±SD) SSI was 1.14 ± 0.22 (range, 0.66–1.78) in all subjects and affected by age significantly after age of 35 (P < 0.05). In univariate regression models, SSI did not vary with biomechanical intraocular pressure (bIOP) (P=0.989), steepest radius of anterior corneal curvature (RsF) (P=0.984) or central corneal thickness (CCT) (P=0.651). In multivariate regression models, SSI was significantly associated with age (β=0.557, P<0.001), axial length (AL) (β=-0.550, P<0.001), intraocular pressure (IOP) (β=0.377, P<0.001) and flattest radius of anterior corneal curvature (RfF) (β=0.222, P<0.001) but not with anterior chamber volume (ACV).Conclusions: SSI was increased by age after the age of 35. In addition to age, SSI and RfF, IOP is positively correlated and negatively correlated with AL.

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Relationship between the biomechanical properties of the cornea and anterior segment measurements

Cited by 4 publications

References 32 publications

Age distribution and associated factors of cornea biomechanical parameter stress-strain index in Chinese healthy population

Age distribution and associated factors of cornea biomechanical parameter stress-strain index in Chinese healthy population

Correlations between corneal biomechanics and specular microscopy in patient with cataract

Age Distribution and Associated Factors of Cornea Biochemical Parameter Stress-Strain Index in Chinese Healthy Population

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