Liver biopsy may facilitate pancreatic graft evaluation: Positive association between liver steatosis and pancreatic graft adipose infiltration

Nacif, Lucas Souto; Rocha-Santos, Vinícius; Claro, Laura C. L.; Vintimilla, Agustín; Ferreira, LA; Arantes, Rubens Macedo; Pinheiro, Rafael Soares; Andraus, Wellington; Alves, Venâncio Avancini Ferreira; D’Albuquerque, Luiz Carneiro

doi:10.6061/clinics/2018/e49

Cited by 7 publications

(5 citation statements)

References 13 publications

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“…To this end, several studies have attempted to characterize pancreatic steatosis in humans using histopathology 10,11 and in vivo imaging techniques, including magnetic resonance imaging (MRI), [12][13][14][15][16][17][18][19][20] magnetic resonance spectroscopy (MRS), [21][22][23][24] ultrasonography, [25][26][27][28][29][30][31][32][33] computed tomography (CT), [34][35][36] and combinations of these techniques. 37,38 Although MRI and MRS remain the most sensitive imaging options for estimating donor pancreas fat content in vivo, these techniques are time-consuming and impractical to incorporate into the donor workflow.…”

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confidence: 99%

Hypertension, but not body mass index, is predictive of increased pancreatic lipid content and islet dysfunction

Tremmel¹,

Feeney²,

Mitchell³

et al. 2020

American Journal of Transplantation

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Pancreatic steatosis is thought to be a negative risk factor for pancreas transplant outcomes. Despite considering donor body mass index (BMI) and the visualization of intercalated fat as indicators of donor pancreas lipid content, transplant surgeons do not use a quantitative method to directly measure steatosis when deciding to transplant a pancreas. In this study, we used nondiabetic human pancreata donated for research to measure the pancreatic and islet‐specific lipid content to determine which clinical markers correlate best with lipid content. Interestingly, we found that BMI and age correlate with increased pancreatic lipid content (Panc‐LC) in men, but not women. Our findings further suggest that total Panc‐LC correlates with an increase in islet lipid content for both men and women. We noted that pancreata donated from individuals with a history of hypertension have increased Panc‐LC independent of donor BMI or sex. Moreover, we identify hypertension as a risk factor for reduced islet function after islet isolation. Together, our findings emphasize differences in pancreas graft quality related to pancreatic and islet lipid content, which may not be predicted by assessing BMI alone but may be influenced by a donor history of hypertension.

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mentioning

confidence: 99%

Hypertension, but not body mass index, is predictive of increased pancreatic lipid content and islet dysfunction

Tremmel¹,

Feeney²,

Mitchell³

et al. 2020

American Journal of Transplantation

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“…Another study revealed that pancreatic steatosis is common in patients with NAFLD and pancreatic fat content positively correlates with liver steatosis grading determined by histology (Nacif et al, 2018).…”

Section: Hyperechogenic Pancreas Can Be Seen In Both Pancreatic Fibro...mentioning

confidence: 98%

Studying the Association Between Non-Alcoholic Fatty Liver Disease and Non-Alcoholic Fatty Pancreas Disease Using Transabdominal Ultrasound and Endoscopic Ultrasound

Sameh Hamed El-Esawy,

AbdAl-Kareem Al-Dahshan,

Salah Ali

et al. 2023

Al-Azhar Medical Journal

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Background: Non-alcoholic fatty liver disease (NAFLD) is characterized by hepatic triglyceride accumulation not due to alcohol consumption (<20 g ethanol per day), resulting in steatosis and hepatic inflammation. NAFLD is currently the most common liver disorder, particularly in Western countries. Worldwide, the prevalence of NAFLD is about 25%. Nonalcoholic fatty pancreas disease (NAFPD) is an excessive lipid accumulation in the pancreas in the absence of significant alcohol intake. Endoscopic ultrasound (EUS) can provide detailed images of the entire pancreas. The use of high-frequency US waves and the ability to simultaneously image adjacent organs like the liver and spleen in real-time. Objective:To determine the possible association between non-alcoholic fatty pancreatic disease (NAFPD) and non-alcoholic fatty liver disease (NAFLD). Patients and methods:This study was conducted on 100 subjects divided into two equal groups: Group I Included individuals with sonographically proven NAFLD, and Group II (control group): Included healthy individuals with no sonographic evidence of NAFLD. All cases were selected from Internal Medicine

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“…Pancreatic steatosis is common in patients with NAFLD, and pancreatic fat content positively correlates with liver steatosis grading determined by histology (46,47) . Patients with histologydetermined liver fibrosis have significantly less pancreatic fat infiltration than those without evidence of liver fibrosis (48) .…”

Section: Correlation Between Non-alcoholic Fatty Liver and Non-alcoho...mentioning

confidence: 99%

Pancreatic Steatosis: A New Diagnosis and Therapeutic Challenge in Gastroenterology

Paul

Shihaz

2020

Arq. Gastroenterol.

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Fat infiltration in the pancreas is called pancreatic steatosis and it has several synonyms such as pancreatic lipomatosis, non-alcoholic fatty pancreatic disease, lipomatous pseudohypertrophy, fatty replacement, fatty pancreas and fatty infiltration. Pancreatic steatosis describes a disease ranging from infiltration of fat in the pancreas to pancreatic inflammation, and development of pancreatic fibrosis. There are multiple aetiologies of this condition, such as metabolic syndrome, alcohol intake, viral infections, toxins, congenital syndromes, etc. Pancreatic steatosis is usually diagnosed by trans-abdominal ultrasound, computed tomography scan and magnetic resonance imaging. Fatty infiltration in pancreas may lead to pancreatitis, diabetes mellitus and may be a predisposing cause of pancreatic cancer. Now a day, pancreatic steatosis is a common incidental finding during abdominal ultrasonography for other reasons and is a new challenge in Gastroenterology. But there is no guideline for pancreatic steatosis till now. In this review article, we are trying to give an overall idea (aetiologies, diagnosis, management, clinical significances) on pancreatic steatosis.

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Liver biopsy may facilitate pancreatic graft evaluation: Positive association between liver steatosis and pancreatic graft adipose infiltration

Cited by 7 publications

References 13 publications

Hypertension, but not body mass index, is predictive of increased pancreatic lipid content and islet dysfunction

Hypertension, but not body mass index, is predictive of increased pancreatic lipid content and islet dysfunction

Studying the Association Between Non-Alcoholic Fatty Liver Disease and Non-Alcoholic Fatty Pancreas Disease Using Transabdominal Ultrasound and Endoscopic Ultrasound

Pancreatic Steatosis: A New Diagnosis and Therapeutic Challenge in Gastroenterology

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