Helicobacter Pylory infection in patients with esophageal squamous cell carcinoma

Poyrazoglu, Omer Bilgehan; Dülger, Ahmet Cumhur; Gültepe, Bilge

doi:10.6061/clinics/2017(03)04

Cited by 10 publications

(12 citation statements)

References 21 publications

(20 reference statements)

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“…Table 1 summarized the baseline characteristics of the included studies. Twelve studies from North America [17–20, 28, 40, 46, 48, 50, 54–56], ten studies from Europe [26, 32, 33, 36, 39, 42, 43, 49, 52, 53], eight studies from East Asia [27, 31, 37, 38, 44, 45, 47, 51], four studies from the Middle East [29, 30, 34, 41], and one study from Oceania [35]. Regarding the study type, thirty-three of them are case-control studies [17–20, 27–30, 32–56] and two of them are cohort studies [26, 31].…”

Section: Resultsmentioning

confidence: 99%

“…Table 2(b) contains the data of esophageal adenocarcinoma, with a total of 308,772 patients, including 7,687 patients in the case group and 301,085 patients in the control group. Furthermore, 14 studies involved esophageal adenocarcinoma [18, 19, 28, 39–42, 46, 48, 50, 53–56], 15 studies involved esophageal squamous cell carcinoma [17, 27, 29–34, 36–38, 44, 45, 47, 51], and 6 studies involved both types [20, 26, 35, 43, 49, 52]. According to the Newcastle-Ottawa Scale, sixteen studies were ranked as very good [17, 19, 20, 26, 29, 32, 33, 35, 39, 40, 43, 44, 48–50, 56], seventeen as good [18, 28, 31, 34, 36–38, 41, 42, 45–47, 51–55], and two as satisfactory [27, 30] ().…”

Section: Resultsmentioning

confidence: 99%

“…According to the ROBINS-I tool, four studies had a serious risk of bias [19, 34, 37, 46], 26 studies had a moderate risk of bias [17, 18, 20, 26, 27, 29–31, 33, 35, 38–43, 45, 47–51, 53–56], and five of the other studies had a low risk of bias [28, 32, 36, 44, 52] ().…”

Section: Resultsmentioning

confidence: 99%

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Systematic Review with Meta-analysis: Association of Helicobacter pylori Infection with Esophageal Cancer

Gao

Zhang

et al. 2019

Gastroenterology Research and Practice

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Background Helicobacter pylori is an important carcinogenic factor in gastric cancer. Studies have shown that Helicobacter pylori infection is inversely associated with certain diseases such as esophageal cancer and whose infection appears to have a “protective effect.” At present, the relationship between Helicobacter pylori infection and esophageal cancer remains controversial. This study was designed to investigate the relationship between Helicobacter pylori infection and the risk of esophageal cancer in different regions and ethnicities. Methods Systematic search of the articles on the relationship between Helicobacter pylori infection and esophageal cancer from the database with the duration time up to December 2018. This systematic review was performed under the MOOSE guidelines. Results This meta-analysis included 35 studies with 345,886 patients enrolled. There was no significant correlation between Helicobacter pylori infection and esophageal squamous cell carcinoma in the general population (OR: 0.84; 95% CI: 0.64-1.09/OR: 0.74; 95% CI: 0.54-0.97). However, a significant correlation was found in the Middle East (OR: 0.34; 95% CI: 0.22-0.52/95% CI: 0.26-0.44). There was no significant difference in the prevalence of Helicobacter pylori between the case group and the control group in esophageal adenocarcinoma (8.87% vs. 9.67%). The pooled OR was 0.55 (95% CI: 0.43-0.70) or 0.23 (95% CI: 0.15-0.36). When grouped by match or not, the pooled OR of the nonmatching group and the matching group was 0.48/0.21 (95% CI: 0.36-0.65/95% CI: 0.13-0.36) and 0.73/0.71 (95% CI: 0.57-0.92/95% CI: 0.60-0.84), respectively. Conclusion In the general populations, no significant association was found between Helicobacter pylori infection and the risk of esophageal squamous cell carcinoma. However, lower risk was found in the Middle East. Helicobacter pylori infection may reduce the risk of esophageal adenocarcinoma, but such “protection effect” may be overestimated.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Systematic Review with Meta-analysis: Association of Helicobacter pylori Infection with Esophageal Cancer

Gao

Zhang

et al. 2019

Gastroenterology Research and Practice

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“…LEfSe analysis found that the high risk of ESCC may be related to Phascolarctobacterium, Dialister, Clostridiales, S24_7, Rikenellaceae, and so on. Currently, Helicobacter pylori (H.pylori) infection is generally associated with EA [40], but whether or not ESCC is related to this infection remains controversial [41,42]. The presents tudy found that the abundance of Helicobacter ora in the EC group was reduced, but this genus has a large number of strains, and the correlation between H. pylori and ESCC needs to be studied.…”

Section: Discussionmentioning

confidence: 99%

Characteristics of Esophagus Flora in Patients with Esophageal Squamous Cell Carcinoma in Central China

He¹,

Liu²,

Gao³

et al. 2020

Preprint

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Microecology may be involved in tumorigenesis and development through the introduction of chronic inflammation and may be related to esophageal squamous cell carcinoma (ESCC). This study was to observe the characteristics of ESCC flora and to preliminarily analyze the key genera in ESCC. A total of 72 ESCC patients and 20 healthy individuals esophageal tissue samples, genomic DNA was extracted, PCR was performed on the bacterial 16SrRNA gene sequence V4 hypervariable region, and bacterial characteristics were analyzed by IlluminMiSeq sequencing. The esophageal flora abundance of ESCC patients (Alpha diversity: Shannon index, P = 0.5088; Simpson index, P = 0.5894; Chao1 index, P = 0.0029) and variability (Beta diversity: PC1 16.62%, P PC1 = 0.0034, P PC2 =8.5e-08) were significantly higher than HC tissue. The five most abundant phylum in ESCC group were Firmicutes, Bacteroidietes, Proteobacteria, Fusobacteria and Actinobacteria, while the HC group were Proteobacteria, Firmicutes, Bacteroidietes, Fusobacteria and Actinobacteria. The top five genus in the ESCC group were Streptococcus, Prevotella, Haemophilus, Neisseria and Veillonella; while the top five genus in the HC group were Streptococcus, Neisseria, Veillonella, Prevotella and Haemophilus. The ESCC group has advantages over HC in Aerobic、Anaerobic、Contains-Mobile-Elements、Facultatively-Anaerobic、Forms-Biofilms、Potentially-pathogenic、Stress-Tolerant, and the difference was statistically significant (P <0.05). The esophageal microbial community structure of ESCC patients is different from that of HC, suggesting that the corresponding changes in esophageal microflora have a certain correlation with ESCC. It indicates that the detection of esophageal microorganisms has potential as a means of early diagnosis or screening of future ESCC.

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“…A partir da descoberta da associação do H. pylori com diversas enfermidades do sistema digestório, muitos estudos objetivaram caracterizar sua distribuição e epidemiologia de doenças a ele relacionadas 2 . Estudos recentes demonstraram que essa bactéria pode interferir em muitos processos biológicos e determinar ou influenciar a ocorrência de muitas doenças extra-digestivas 3 .…”

Section: Clínica Médicaunclassified

Doenças relacionadas à infecção pelo Helicobacter pylori

Quintairos¹,

Sá²,

Sousa³

et al. 2020

PRMJ

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Copyright Quintairos et al. Este é um artigo publicado em acesso aberto (Open Access) sob a licença Creative Commons Attribution, que permite uso, distribuição e reprodução em qualquer meio, sem restrições desde que o trabalho original seja corretamente citado.Resumo Objetivo: Realizar uma revisão de literatura a respeito das doenças mais prevalentes relacionadas à infecção pelo H. pylori. Método: Tema pesquisado por meio da Base de Dados Lilacs, Pubmed, Google acadêmico e Scielo, com os termos H. pylori e dispepsia, período de 2014 a 2019 utilizando os termos cadastrados nos Descritores em Ciências da Saúde como: helicobacter pylori, dispepsias e suas correspondentes em inglês: Helicobacter pylori, Patologia. Nesse contexto, foram selecionados artigos em português, espanhol e inglês, a maioria com enfoque nas doenças associadas à infecção por Helicobacter Pylori. Resultados: Foram encontrados 2907 resultados com base nos descritores e, destes, atendendo os critérios de inclusão e exclusão, foram utilizados 1 no Lilacs, 10 no Pubmed, 1 no Google acadêmico e 1 no Scielo. Conclusão: As doenças relacionadas à infecção pelo H. pylori são fontes de numerosos estudos literários. Esta pesquisa envolve a relação do H. pylori com psoríase, periodontite crônica, câncer gástrico, anemia e com PTI. Descritores: helicobacter pylori; dispesia; infecção.Summary Purpose: To perform a literature review on the most prevalent diseases related to H. pylori infection. Methods: Topic searched through the Lilacs, Pubmed, Google Scholar and Scielo Database, with the terms H. pylori and dyspepsia, from 2014 to 2019 using the terms registered in the Health Sciences Descriptors as: helicobacter pylori, dyspepsias and their English correspondents: Helicobacter pylori, Pathology. In this context, articles were selected in Portuguese, Spanish and English, most focusing on diseases associated with Helicobacter Pylori infection. Results: A total of 2907 results were found based on the descriptors. Of these, meeting the inclusion and exclusion criteria, 1 was used in Lilacs, 10 in Pubmed, 1 in Google Scholar and 1 in Scielo. Conclusion: Diseases related to infection with H. pylori are sources of numerous literary studies. This research involves the relationship of H. pylori with psoriasis, chronic periodontitis, gastric cancer, anemia and with ITP.

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Helicobacter Pylory infection in patients with esophageal squamous cell carcinoma

Cited by 10 publications

References 21 publications

Systematic Review with Meta-analysis: Association of Helicobacter pylori Infection with Esophageal Cancer

Systematic Review with Meta-analysis: Association of Helicobacter pylori Infection with Esophageal Cancer

Characteristics of Esophagus Flora in Patients with Esophageal Squamous Cell Carcinoma in Central China

Doenças relacionadas à infecção pelo Helicobacter pylori

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