Background Helicobacter pylori is an important carcinogenic factor in gastric cancer. Studies have shown that Helicobacter pylori infection is inversely associated with certain diseases such as esophageal cancer and whose infection appears to have a “protective effect.” At present, the relationship between Helicobacter pylori infection and esophageal cancer remains controversial. This study was designed to investigate the relationship between Helicobacter pylori infection and the risk of esophageal cancer in different regions and ethnicities. Methods Systematic search of the articles on the relationship between Helicobacter pylori infection and esophageal cancer from the database with the duration time up to December 2018. This systematic review was performed under the MOOSE guidelines. Results This meta-analysis included 35 studies with 345,886 patients enrolled. There was no significant correlation between Helicobacter pylori infection and esophageal squamous cell carcinoma in the general population (OR: 0.84; 95% CI: 0.64-1.09/OR: 0.74; 95% CI: 0.54-0.97). However, a significant correlation was found in the Middle East (OR: 0.34; 95% CI: 0.22-0.52/95% CI: 0.26-0.44). There was no significant difference in the prevalence of Helicobacter pylori between the case group and the control group in esophageal adenocarcinoma (8.87% vs. 9.67%). The pooled OR was 0.55 (95% CI: 0.43-0.70) or 0.23 (95% CI: 0.15-0.36). When grouped by match or not, the pooled OR of the nonmatching group and the matching group was 0.48/0.21 (95% CI: 0.36-0.65/95% CI: 0.13-0.36) and 0.73/0.71 (95% CI: 0.57-0.92/95% CI: 0.60-0.84), respectively. Conclusion In the general populations, no significant association was found between Helicobacter pylori infection and the risk of esophageal squamous cell carcinoma. However, lower risk was found in the Middle East. Helicobacter pylori infection may reduce the risk of esophageal adenocarcinoma, but such “protection effect” may be overestimated.

Aims: To profile and characterize the circular RNA (circRNA) expression pattern in poorly differentiated gastric adenocarcinoma (PDGA). Methods & materials: CircRNA expression profiles in PDGA and adjacent nontumor tissues were analyzed by microarray. Five randomly selected differentiated expressed circRNAs (DECs) were validated by real-time quantitative PCR. m6A qualification of the top 20 DECs was conducted by m6A-immunoprecipitation and real-time quantitative PCR. Results: A total of 65 DECs were found in PDGA compared with the control. Hsa_circRNA_0077837 had the largest area under the curve. Most DECs had m6A modifications, the trend of m6A modification alteration was mainly consistent with the circRNA expression level. Conclusion: Our study revealed a set of DECs and their m6A modification alterations, which may provide new insight for their potential function in PDGA.

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Background and AimHiatal hernia (HH) has been found in a large number of people, but there has been no unified way to diagnose it. The aim of this study was to compare the diagnostic efficiency of X‐ray, endoscopy, and high‐resolution manometry (HRM) in the diagnosis of HH using surgical diagnosis of HH as the gold standard.MethodsTwo biomedical databases (PubMed and EMBASE) were systematically searched through January 26, 2019. The pooled sensitivity, specificity, and area under the SROC curve (AUC) were calculated, and the AUC statistical significance was compared by Tukey's multiple comparisons test.ResultsA total of 5337 patients in seven articles were included. The pooled sensitivity, specificity, and AUC for X‐ray were 0.63 (0.46–0.77), 0.85 (0.69–0.94), and 0.80 (0.77–0.84), respectively, for diagnosing HH. The pooled estimates for endoscopy in diagnosing HH were as follows: sensitivity, 0.72 (0.39–0.91); specificity, 0.80 (0.70–0.87); and AUC, 0.82 (0.78–0.85). Similarly, the corresponding values for HRM were 0.77 (0.70–0.83); 0.92 (0.85–0.96), and 0.9527. Tukey's multiple comparisons tests were used to compare the AUCs of the three diagnostic methods: No significant differences were found between X‐ray and endoscopy (P = 0.7293), and HRM was superior to X‐ray (P = 0.0127) and endoscopy (P = 0.0442).ConclusionsHigh‐resolution manometry may exhibit a better diagnostic performance for hiatal hernia. In contrast, X‐ray and endoscopy may not be the best methods, and there was no significant difference in diagnostic efficiency between the X‐ray and endoscopy.

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For an Otto cycle there always exists a trade-off between the cycle efficiency and the output power due to the requirement of cycle length. The shortcut to adiabatic (STA) technology provides an effective way to deal with the difficulty of zero-output power in conventional Otto cycle. In this paper, the Otto cycle of three-qubit system as the working substance (WS) with counterdiabatic (CD) driving has been investigated. It is demonstrated that the tripartite Otto cycle as a universal machine, in the suitable regimes of external control parameter, could work as a quantum heat engine (QHE), refrigerator or heat pump. And, the performances of QHE and refrigerator with and without STA, such as the power and efficiency of QHE and the coefficient of performance (COP) and figure of merit (FOM)) of refrigerator, have been investigated. It shows the application of STA scheme can lead to an effective enhancement in the performances of Otto cycle, including achievements of a high QHE’s/refrigerator’s power associated with a moderate QHE’s efficiency/COP of refrigerator. Especially, it is interesting that even in a short-time cycle the optimization of control parameters could arise a remarkable improvement in the efficiency (or COP) of STA QHE (refrigerator), approaching the ideal efficiency or COP of conventional Otto cycle with quasi-static process. Finally, with the aid of parameter optimization the trade-off regions between the efficiency and the power (the COP and the FOM) of STA Otto engine (refrigerator) have been advised.

Background: Poorly differentiated gastric adenocarcinoma (PDGA) is a common adenocarcinoma with less glandular structure in gastric cancer. To date, the factors affecting its prognosis remain unclear. In this study, we establish a novel prognostic nomogram for PDGA. Methods:We screened the Surveillance, Epidemiology, and End Results (SEER) database and downloaded data from PDGA patients who underwent surgery between 2010 and 2015. We explored their clinicopathological characteristics and important prognostic factors such as overall survival (OS), using univariate and multivariate Cox proportional hazards regression analyses, then constructed a prognostic nomogram using the resulting significant variables to predict the OS. We verified performance of the nomogram externally using a separate Chinese set, and further compared its ability as well as the 8 th edition of the American Joint Committee on Cancer (AJCC) staging system to predict prognosis.Results: A total of 3,887 patients in the SEER database met our inclusion criteria and were therefore included in the analysis. Multivariate analysis showed that age, sex, tumor size, prime site of tumor, T stage, N stage, and M stage were all independent prognostic factors for PDGA. These factors allowed successful establishment of a nomogram model with high predictive power, based on external verification using a Chinese set comprising 632 PDGA patients. The nomogram showed a better discrimination advantage than the 8 th edition of the AJCC staging system in predicting OS (C-index of nomogram vs. AJCC staging for SEER set: 0.707 vs. 0.663; Chinese set: 0.788 vs. 0.713). Conclusions:The nomogram, established herein, was more accurate in predicting the 1-, 3-, and 5-year OS of PDGA patients than the traditional AJCC TNA staging system. Successful establishment of a PDGA prognostic nomogram is a further step towards individualized and precise treatment of gastric cancer.

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