In vivo standardization of bone ultrasonometry of the clavicle

Abstract

OBJECTIVE:The assessment of fracture union includes physical examination and radiographic imaging, which depend on the examiner's experience. The development of ancillary methods may avoid prolonged treatments and the improper removal of implants. Quantitative bone ultrasonometry has been studied for this purpose and will soon be included in clinical practice. The aims of the present study were to assess the feasibility of using this technique on the clavicle and to standardize its in vivo application.METHODS:Twenty adult volunteers, including 10 men and 10 women without medical conditions or a previous history of clavicle fracture, underwent axial quantitative ultrasonometric assessment using transducers in various positions (different distances between the transducers and different angulations relative to the clavicle).RESULTS:Similar values of wave propagation velocity were obtained in the different tested set-ups, which included distinct distances between the transducers and angular positions relative to the clavicle. There were significant differences only in the transducers positioned at 0° and at 5 or 7 cm apart.CONCLUSIONS:The use of bone ultrasonometry on the clavicle is feasible and the standardization of the technique proposed in this study (transducers placed at 45° and at 7 cm apart) will allow its future application in clinical trials to evaluate the healing process of diaphyseal fractures of the clavicle.

Ex vivo vibro-acoustography characterization of osteoporosis in an experimental mice model

“…QUS is not used to obtain images, but to measure and assess tissue properties (60). This modality may be used to evaluate osteoporosis (61,62) and fracture healing (63)(64)(65). QUS is a low-cost technique that has been applied at different anatomical sites, but according to the International Society for Clinical Densitometry (ISCD) official guideline (66) the only validated skeletal site is the calcaneus.…”

Preliminary results of vibro-acoustography evaluation of bone surface and bone fracture

“…More recently nonlinear resonant ultrasound spectroscopy technique has been used to monitor fatigue cortical bone micro damage (22). Ultrasonometry may be used to identify bone fractures in experimental and in vivo studies and to monitor fracture healing (23)(24)(25)(26)(27). To our knowledge, we found no previous papers showing VA images of bone fractures.…”

Caracterização da resposta acústica por vibro-acustografia em fêmures de camundongos em um modelo experimental ex-vivo

“…Gráfico 4 -Gráficos de dispersão demonstrando demais correlações entre a vibroacustografia e o microCT em (a) BV/TV (r=0,19; p<0,47) e (b) espessura trabecular de conectividade (r=-0,34; p<0,20). GUEDES et al, 2019;MA, 1999;YAO, 2001;KOMORI, 2015;LELOVAS et al, 2008;MANDARANO-FILHO;BEZUTI;VOLPON et al, 2015;ZAMARIOLI et al, 2013). Embora não tenhamos utilizado os modelos mais comuns de osteoporose experimental da literatura, a perda óssea trabecular obtida foi equivalente a esses outros modelos.…”

“…O QUS não é usado para obter imagens, mas sim para quantificar propriedades mecânicas dos tecidos (BARKMANN, 2008). Desse modo, pode ser usada para diagnosticar a osteoporose (MINONZIO et al, 2019;RINALDO et al, 2018;WÜSTER et al, 2009), porém pode ser usada também para avaliar a consolidação de fraturas (BARBIERI et al, 2012;BEZUTI et al, 2013;MANDARANO-FILHO;BEZUTI;MESQUITA;BARBIERI;XU et al, 2014). A QUS é uma técnica de baixo custo e que pode ser aplicada em diferentes locais anatômicos, porém, de acordo com as diretrizes oficiais da Sociedade Internacional de Densitometria Clínica (ISCD) (HANS; BAIM, 2017), o único local validado para diagnóstico de osteoporose é o calcâneo.…”